Skip to main content
Top

2024 | OriginalPaper | Chapter

Silk Biomaterials in Wound Healing: Navigating Challenges and Charting the Future of Regenerative Medicine

Authors : Best Atoe, Ikhazuagbe H. Ifijen, Igbako Philip Okiemute, Okeke I. Emmanuel, Muniratu Maliki

Published in: TMS 2024 153rd Annual Meeting & Exhibition Supplemental Proceedings

Publisher: Springer Nature Switzerland

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Wound healing and skin regeneration are complex processes crucial for human health, and silk biomaterials have emerged as promising tools in these fields. This article explores recent research, challenges, and prospects in the use of silk-based solutions for wound healing and regenerative medicine. Recent studies highlight silk biomaterials’ potential in promoting wound healing and skin regeneration through materials like hydrogels, dressings, and artificial skin grafts. Silk's unique ability to modulate immune responses balances inflammation and tissue repair, making it invaluable in wound care. However, challenges such as regulatory compliance, infection management, and immunomodulation must be addressed. Bridging the gap between research and clinical application demands rigorous testing and personalized wound care approaches. The future of silk biomaterials in wound healing holds promise, with innovations like advanced formulations, bioactive additives, and immunomodulation on the horizon. Regulatory streamlining will make silk-based solutions globally accessible, revolutionizing wound care and advancing regenerative medicine.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Literature
1.
go back to reference Jonathan EM, Ohifuemen AO, Jacob JN, Isaac AY, Ifijen IH (2023) Polymeric biodegradable biomaterials for tissue bioengineering and bone rejuvenation. In: TMS 2023 152nd annual meeting & exhibition supplemental proceedings. The minerals, metals & materials series. Springer, Cham. https://doi.org/10.1007/978-3-031-22524-6_25 Jonathan EM, Ohifuemen AO, Jacob JN, Isaac AY, Ifijen IH (2023) Polymeric biodegradable biomaterials for tissue bioengineering and bone rejuvenation. In: TMS 2023 152nd annual meeting & exhibition supplemental proceedings. The minerals, metals & materials series. Springer, Cham. https://​doi.​org/​10.​1007/​978-3-031-22524-6_​25
2.
5.
go back to reference Ifijen IH, Maliki M, Udokpoh NU, Odiachi IJ, Atoe B (2023) A concise review of the antibacterial action of gold nanoparticles against various bacteria. In: TMS 2023 152nd annual meeting & exhibition supplemental proceedings. The minerals, metals & materials series. Springer, Cham. https://doi.org/10.1007/978-3-031-22524-6_58 Ifijen IH, Maliki M, Udokpoh NU, Odiachi IJ, Atoe B (2023) A concise review of the antibacterial action of gold nanoparticles against various bacteria. In: TMS 2023 152nd annual meeting & exhibition supplemental proceedings. The minerals, metals & materials series. Springer, Cham. https://​doi.​org/​10.​1007/​978-3-031-22524-6_​58
6.
go back to reference Altman GH, Diaz F, Jakuba C, Calabro T, Horan RL, Chen J, Kaplan DL (2003) Silk-based biomaterials. Biomaterials 24:401–416 Altman GH, Diaz F, Jakuba C, Calabro T, Horan RL, Chen J, Kaplan DL (2003) Silk-based biomaterials. Biomaterials 24:401–416
7.
go back to reference Kundu SC, Kundu B, Talukdar S, Bano S, Nayak S, Kundu J, Ghosh AK (2012) Invited review nonmulberry silk biopolymers. Biopolymers 97:455–467 Kundu SC, Kundu B, Talukdar S, Bano S, Nayak S, Kundu J, Ghosh AK (2012) Invited review nonmulberry silk biopolymers. Biopolymers 97:455–467
8.
go back to reference Widhe M, Johansson J, Hedhammar M, Rising A (2012) Current progress and limitations of spider silk for biomedical applications. Biopolymers 97:468–478CrossRefPubMed Widhe M, Johansson J, Hedhammar M, Rising A (2012) Current progress and limitations of spider silk for biomedical applications. Biopolymers 97:468–478CrossRefPubMed
9.
go back to reference Holland C, Numata K, Rnjak-Kovacina J, Seib FP (2019) The biomedical use of silk: past, present, future. Adv Healthcare Mater 8:e1800465CrossRef Holland C, Numata K, Rnjak-Kovacina J, Seib FP (2019) The biomedical use of silk: past, present, future. Adv Healthcare Mater 8:e1800465CrossRef
10.
go back to reference Rockwood DN, Preda RC, Yucel T, Wang X, Lovett ML, Kaplan DL (2011) Materials fabrication from Bombyx mori silk fibroin. Nat Protoc 6:1612–1631CrossRefPubMed Rockwood DN, Preda RC, Yucel T, Wang X, Lovett ML, Kaplan DL (2011) Materials fabrication from Bombyx mori silk fibroin. Nat Protoc 6:1612–1631CrossRefPubMed
11.
go back to reference Inoue S, Tanaka K, Arisaka F, Kimura S, Ohtomo K, Mizuno S (2000) Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio. J Biol Chem 275:40517–40528CrossRefPubMed Inoue S, Tanaka K, Arisaka F, Kimura S, Ohtomo K, Mizuno S (2000) Silk fibroin of Bombyx mori is secreted, assembling a high molecular mass elementary unit consisting of H-chain, L-chain, and P25, with a 6:6:1 molar ratio. J Biol Chem 275:40517–40528CrossRefPubMed
12.
go back to reference Kundu B, Rajkhowa R, Kundu SC, Wang X (2013) Silk fibroin biomaterials for tissue regenerations. Adv Drug Deliv Rev 65:457–470CrossRefPubMed Kundu B, Rajkhowa R, Kundu SC, Wang X (2013) Silk fibroin biomaterials for tissue regenerations. Adv Drug Deliv Rev 65:457–470CrossRefPubMed
17.
go back to reference Asakura T, Ashida J, Yamane T, Kameda T, Nakazawa Y, Ohgo K, Komatsu K (2001) A repeated β-turn structure in Poly(Ala-Gly) as a model for silk I of Bombyx mori silk fibroin studied with two-dimensional spin-diffusion NMR under off magic angle spinning and rotational echo double resonance. J Mol Biol 306(2):291–305. https://doi.org/10.1006/jmbi.2000.4394CrossRefPubMed Asakura T, Ashida J, Yamane T, Kameda T, Nakazawa Y, Ohgo K, Komatsu K (2001) A repeated β-turn structure in Poly(Ala-Gly) as a model for silk I of Bombyx mori silk fibroin studied with two-dimensional spin-diffusion NMR under off magic angle spinning and rotational echo double resonance. J Mol Biol 306(2):291–305. https://​doi.​org/​10.​1006/​jmbi.​2000.​4394CrossRefPubMed
18.
24.
go back to reference Kumari S, Lang G, DeSimone E, Spengler C, Trossmann VT, Lücker S, Scheibel T (2020) Engineered spider silk-based 2D and 3D materials prevent microbial infestation. Mater Today 41:21–33 Kumari S, Lang G, DeSimone E, Spengler C, Trossmann VT, Lücker S, Scheibel T (2020) Engineered spider silk-based 2D and 3D materials prevent microbial infestation. Mater Today 41:21–33
32.
go back to reference Periayah MH, Halim AS, Mat Saad AZ (2017) Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. Int J Hematol Oncol Stem Cell Res 11(4):319–327PubMedPubMedCentral Periayah MH, Halim AS, Mat Saad AZ (2017) Mechanism action of platelets and crucial blood coagulation pathways in hemostasis. Int J Hematol Oncol Stem Cell Res 11(4):319–327PubMedPubMedCentral
Metadata
Title
Silk Biomaterials in Wound Healing: Navigating Challenges and Charting the Future of Regenerative Medicine
Authors
Best Atoe
Ikhazuagbe H. Ifijen
Igbako Philip Okiemute
Okeke I. Emmanuel
Muniratu Maliki
Copyright Year
2024
DOI
https://doi.org/10.1007/978-3-031-50349-8_78

Premium Partners