Skip to main content
Disciplines
Automotive Business IT + Informatics Construction + Real Estate Electrical Engineering + Electronics Energy + Sustainability Insurance + Risk Finance + Banking Management + Leadership Marketing + Sales Mechanical Engineering + Materials
Events
DE
EN
Books
Journals
Topic Page
Marketing
Start single access now
Access for companies
EXTENDED SEARCH
Log in
Top
Journal of Materials Science
Published in: Journal of Materials Science 5/2019

20-11-2018 | Materials for life sciences

Silk fibroin coaxial bead-on-string fiber materials and their drug release behaviors in different pH

Authors: Huanjie Xi, Huijing Zhao

Published in: Journal of Materials Science | Issue 5/2019

Log in

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

Inspired by the different pH between normal tissue and tumor tissue, pH-responsive drug release materials need to be designed to achieve drug-controlled release. Electrospinning is a simple and efficient method to fabricate drug loading and releasing materials. However, burst release of electrospun smooth fibers was often observed in drug delivery process, which is very harmful to the human body. To develop materials with drug sustained release behaviors in tumor tissue environment, different morphologies of electrospun materials should be designed and fabricated. In this study, silk fibroin smooth fiber materials, bead-on-string fiber materials and coaxial bead-on-string fiber materials were fabricated and their drug release behaviors were compared in different pH. The drug release experiments showed that the electrospun materials showed pH-sensitive releasing behaviors. They released faster and more amount of drugs in acid buffer. Besides, the electrospun coaxial bead-on-string fiber material has a slower release rate compared with the smooth fiber and bead-on-string fiber materials. The coaxial bead-on-string fiber material is an efficient and of potential for being used as sustained drug delivery system to treat cancers.
previous article Origin of efficiency enhancement in cell capture on nanostructured arrays
next article Improved wear, mechanical, and biological behavior of UHMWPE-HAp-zirconia hybrid nanocomposites with a prospective application in total hip joint replacement

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

inform now
Literature
1.
Langer R (1998) Drug delivery and targeting. Nature 392:5–10
2.
Brouwers JR (1996) Advanced and controlled drug delivery systems in clinical disease management. Pharm World Sci 18:153–162CrossRef
3.
Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM (1999) Polymeric systems for controlled drug release. Chem Rev 99:3181–3198CrossRef
4.
Panyam J, Labhasetwar V (2003) Biodegradable nanoparticles for drug and gene delivery to cells and tissue. Adv Drug Deliv Rev 55:329–347CrossRef
5.
6.
Somvipart S, Kanokpanont S, Rangkupan R, Ratanavaraporn J, Damrongsakkul S (2013) Development of electrospun beaded fibers from Thai silk fibroin and gelatin for controlled release application. Int J Biol Macromol 55:176–184CrossRef
7.
Thakur RA, Florek CA, Kohn J, Michniak BB (2008) Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int J Pharm 364:87–93CrossRef
8.
Qi H, Hu P, Xu J (2006) Encapsulation of drug reservoirs in fibers by emulsion electrospinning: morphology characterization and preliminary release assessment. Biomacromol 7:2327–2330CrossRef
9.
Frokjaer S, Otzen D (2005) Protein drug stability: a formulation challenge. Nat Rev Drug Discov 4:298–306CrossRef
10.
Zhang Y, Ouyang H, Lim CT, Ramakrishna S, Huang Z (2005) Electrospinning of gelatin fibers and gelatin/PCL composite fibrous scaffolds. J Biomed Mater Res B 72B:156–165CrossRef
11.
Zhao H, Chi H (2018) Chapter 5: bead-on-string nanofibers: useless or something of value? In: Lin T (ed) Novel aspects of nanofibers. IntechOpen Limited, pp 87–102. ISBN 978-1-78923-075-8
12.
Zhang Y, Wang X, Feng Y (2006) Coaxial electrospinning of (fluorescein isothiocyanate-conjugated bovine serum albumin)-encapsulated poly(ε-caprolactone) nanofibers for sustained release. Biomacromol 7:1049–1057CrossRef
13.
Han F, Liu S, Liu X, Pei Y, Bai S, Zhao H et al (2014) Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues. Acta Biomater 10:921–930CrossRef
14.
Rockwood DN, Preda RC, Yücel T, Wang X, Lovett ML, Kaplan DL (2011) Materials fabrication from Bombyx mori silk fibroin. Nat Protoc 6:1612–1631CrossRef
15.
Cakmak S, Cakmak AS, Kaplan DL, Gumusderelioglu M (2013) A silk fibroin and peptide amphiphile-based co-culture model for osteochondral tissue engineering. Macromol Biosci 16:1212–1226CrossRef
16.
He J, Cheng Y, Cui S (2013) Preparation and characterization of electrospun Antheraea pernyi silk fibroin nanofibers from aqueous solution. J Appl Polym Sci 128:1081–1088CrossRef
17.
Altman GH, Horan RL, Lu HH, Moreau J, Martin I, Richmond JC, Kaplan DL (2002) Silk matrix for tissue engineered anterior cruciate ligaments. Biomaterials 23:4131–4141CrossRef
18.
Liu H, Fan H, Wang Y, Toh SL, Goh JCH (2008) The interaction between a combined knitted silk scaffold and microporous silk sponge with human mesenchymal stem cells for ligament tissue engineering. Biomaterials 29:662–674CrossRef
19.
Unger R (2004) Growth of human cells on a non-woven silk fibroin net: a potential for use in tissue engineering. Biomaterials 25:1069–1075CrossRef
20.
Wang Y, Kim H, Vunjak-Novakovic G, Kaplan DL (2006) Stem cell-based tissue engineering with silk biomaterials. Biomaterials 27:6064–6082CrossRef
21.
Tsioris K, Raja WK, Pritchard EM, Panilaitis B, Kaplan DL, Omenetto FG (2012) Fabrication of silk microneedles for controlled-release drug delivery. Adv Funct Mater 22:330–335CrossRef
22.
Vepari C, Kaplan DL (2007) Silk as a biomaterial. Prog Polym Sci 32:991–1007CrossRef
23.
Wenk E, Merkle HP, Meinel L (2011) Silk fibroin as a vehicle for drug delivery applications. J Control Release 150:128–141CrossRef
24.
Tarallo O (2002) Encyclopedia of polymer science and technology. Wiley, New York
25.
Garric X, Guillaume O, Dabboue H, Vert M, Moles J (2012) Potential of a PLA-PEO-PLA-based scaffold for skin tissue engineering: in vitro evaluation. J Biomat Sci Polym E 23:1687–1700
26.
Ifkovits JL, Burdick JA (2007) Review: photopolymerizable and degradable biomaterials for tissue engineering applications. Tissue Eng 13:2369–2385CrossRef
27.
Jin H, Fridrikh SV, Rutledge GC et al (2002) Electrospinning Bombyx mori silk with poly(ethylene oxide). Biomacromol 3(6):1233–1239CrossRef
28.
Jin H (2004) Human bone marrow stromal cell responses on electrospun silk fibroin mats. Biomaterials 25(6):1039–1047CrossRef
29.
Wang M, Yu JH, Kaplan DL et al (2006) Production of submicron diameter silk fibers under benign processing conditions by two-fluid electrospinning. Macromolecules 39(3):1102–1107CrossRef
30.
Li K, Liu H, Gao W, Chen M, Zeng Y, Liu J et al (2015) Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials 39:131–144CrossRef
31.
32.
33.
34.
35.
Qi R, Tian X, Guo R, Luo Y, Shen M, Yu J, Shi X (2016) Controlled release of doxorubicin from electrospun MWCNTs/PLGA hybrid nanofibers. Chin J Polym Sci 34:1047–1059CrossRef
36.
Chen Y, Qi Y, Liu B (2013) Polyacrylic acid functionalized nanographene as a nanocarrier for loading and controlled release of doxorubicin hydrochloride. J Nanomater 2013:1–8
37.
Ardeshirzadeh B, Anaraki NA, Irani M, Rad LR, Shamshiri S (2015) Controlled release of doxorubicin from electrospun PEO/chitosan/graphene oxide nanocomposite nanofibrous scaffolds. Mater Sci Eng C 48:384–390CrossRef
Metadata
Title
Silk fibroin coaxial bead-on-string fiber materials and their drug release behaviors in different pH
Authors
Huanjie Xi
Huijing Zhao
Publication date
20-11-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 5/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-3137-z

Other articles of this Issue 5/2019

Journal of Materials Science 5/2019 Go to the issue

Composites

Fabrication of well-isolated graphene and evaluation of thermoelectric performance of polyaniline–graphene composite film

Composites

Laser-induced synthesis and photocatalytic properties of hybrid organic–inorganic composite layers

Ceramics

Observation of the transformation of silica phytoliths into SiC and SiO2 particles in biomass-derived carbons by using SEM/EDS, Raman spectroscopy, and XRD

Composites

Improvement of mechanical properties and thermal conductivity of carbon fiber laminated composites through depositing graphene nanoplatelets on fibers

Metals

Formulation of Al–Bi–Sn immiscible alloys versus the solidification behaviors and structures

Computation

Experimental and molecular dynamics simulation study on the damping mechanism of C5 petroleum resin/chlorinated butyl rubber composites

Premium Partners

    Image Credits