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Colloid and Polymer Science

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27-03-2019 | Short Communication

Structural characteristics of mPEG-PDLLA and their effects on micelle stability

Authors: Bumchan Min, Minhyo Seo, Bong Oh Kim, Youngjoo Koh, Yilwoong Yi, Hyerim Kim

Published in: Colloid and Polymer Science | Issue 5/2019

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Abstract

The correlation between polymer microstructure of mPEG-PDLLA and secondary aggregation of its micelle was studied. Close examination of ¹H NMR spectra revealed that the methine moieties, -CH(CH₃)-, of mPEG-PDLLA polymer well represented its microstructure. To elucidate the physicochemical characteristics of various microstructures, we have developed an index, called L-ratio, to indicate the relative content of heterotactic component within the polymer. Storage stability of micelles from six polymers with different L-ratios (L-ratio ranging from 28 to 33%) was studied at 30 °C and 50 °C, and changes in average particle size were monitored to evaluate their secondary aggregation. We have found that polymers with high L-ratio takes longer time to secondary aggregation of polymeric micelles to occur. The findings should provide insightful guidance in the development of polymeric micelles.

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Title: Structural characteristics of mPEG-PDLLA and their effects on micelle stability
Authors: Bumchan Min
Minhyo Seo
Bong Oh Kim
Youngjoo Koh
Yilwoong Yi
Hyerim Kim
Publication date: 27-03-2019
Publisher: Springer Berlin Heidelberg
Published in: Colloid and Polymer Science / Issue 5/2019
Print ISSN: 0303-402X
Electronic ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-019-04495-5

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