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Polymer Bulletin

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05-05-2020 | Original Paper

Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature

Authors: Edin Suljovrujic, Zorana Rogic Miladinovic, Maja Krstic

Published in: Polymer Bulletin | Issue 5/2021

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Abstract

Oligo (ethylene glycol) oligo (propylene glycol) methacrylates (OEGOPGMA) with different numbers of ethylene glycol (EG) and propylene glycol (PG) units in backbone were used for the preparation of new thermoresponsive POEGOPGMA hydrogels; EG₆PG₃MA and EG₃PG₆MA monomers were used; and three different POEGOPGMA hydrogels (PEG₆PG₃MA, PEG₃PG₆MA and P(EG₆PG₃/EG₃PG₆)MA copolymer with equal mol% of previous two) were fabricated from monomer–solvent (OEGOPGMA–water/ethanol) mixture by gamma radiation. Characterisation of the hydrogels was conducted by swelling, UV–Vis, scanning electron microscope, differential scanning calorimetry and in vitro biocompatibility (cytocompatibility and haemolytic activity) investigations. The modelling of drug release and diffusion characteristics was tested using cephalexin drug. For the first time, it was shown how to effectively tune the volume phase transition temperature (VPTT) values of the hydrogels by changing the ratio of more hydrophilic (EG) and more hydrophobic (PG) units in (EGPG) “block” pendant chains. The obtained hydrogels revealed the great potential for different biomedical applications not only due to the possibility to tune VPTT in the desired way but also due to the good biocompatibility and controlled drug delivery within the target temperature range.

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Title: Swelling properties and drug release of new biocompatible POEGOPGMA hydrogels with VPTT near to the human body temperature
Authors: Edin Suljovrujic
Zorana Rogic Miladinovic
Maja Krstic
Publication date: 05-05-2020
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 5/2021
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-020-03217-0

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