Synthesis of green fluorescent cross-linked molecularly imprinted polymer bound with anti-cancerous drug (docetaxel) for targeted drug delivery

An excellent anti-cancer strategy for drug delivery was developed by applying a magnet at the target cancer site. For this purpose, a new docetaxel-loaded magnetic molecularly imprinted polymer (docetaxel-loaded MIP) was synthesized by a magnetic core-shell magnetic nanoparticles of Fe₃O₄, a vitamin C (ascorbic acid) as cross-linker, and a combination polymerization method. The docetaxel-loaded MIP was employed as a transporter of the anti-cancer medicine for continued and controlled release of docetaxel at a target malignant tissue. The magnetic nanoparticles, magnetic core-shell, and MIPs were characterized by SEM, VSM, XRD, and EDX techniques. Many different types of analysis like VSM proved that nanomaterial was magnetic, and the X-ray analysis diagram confirmed the occurrence of nanocarrier at the goal site. The MTT assay demonstrated that increasing the amount of dosage nanomaterial inhibited the growth of cancer cells. The EDX was used to confirm the presence of elements loaded on nanoparticles, silica core-shell, and MIPs. The HPLC chromatogram of mice’s blood plasma confirmed the manifestation of the drug that was collected from the target site.