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Photocatalyzed Formation of Heterocycles Read chapter Read first chapter

2018 | OriginalPaper | Chapter

Synthesis of Nitrogen-Containing Heterocycles via Imidoyl or Iminyl Radical Intermediates

Authors : Jian Lei, Dengke Li, Qiang Zhu

Published in: Free-Radical Synthesis and Functionalization of Heterocycles

Publisher: Springer International Publishing

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Abstract

Synthesis of nitrogen-containing heterocycles with isocyanides, isothiocyanates, nitriles, imines, oxime derivatives, and other related compounds has been deeply investigated in organic synthesis. This chapter mainly focuses on summarizing radical cyclization reactions of these C-N unsaturated precursors to afford N-heterocycles in the past decade as well as some earlier feature examples. In most cases, imidoyl or iminyl radicals are involved in cyclizing onto unsaturated systems or heteroatoms to generate N-heterocycles, such as phenanthridines, (iso)quinolines, pyridines, indoles, and pyrroles. A few examples via other types of radical intermediates starting from isothiocyanates, isocyanates, and analogous structures are also included.

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previous chapter Reductive Electron Transfer in the Synthesis of Heterocycles
next chapter Radical Cascades in the Total Synthesis of Complex Naturally Occurring Heterocycles
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Metadata
Title
Synthesis of Nitrogen-Containing Heterocycles via Imidoyl or Iminyl Radical Intermediates
Authors
Jian Lei
Dengke Li
Qiang Zhu
Copyright Year
2018
Book
Free-Radical Synthesis and Functionalization of Heterocycles

Print ISBN: 978-3-319-89520-8

Electronic ISBN: 978-3-319-89521-5

Copyright Year: 2018

DOI
https://doi.org/10.1007/7081_2017_9

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