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Journal of Nanoparticle Research

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01-12-2017 | Research Paper

Synthesis of novel fluorescently labeled water-soluble fullerenes and their application to its cellar uptake and distribution properties

Authors: Akiko Hashimoto, Takehiro Yamanaka, Takeji Takamura-Enya

Published in: Journal of Nanoparticle Research | Issue 12/2017

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Abstract

Fullerene is a well-known carbon nanomaterial, which can be potentially used for drug manufacture or delivery. Despite several successful examples of utilizing fullerene derivatives as drug candidate materials, their low water solubility under physiological conditions negatively affects the cell penetration efficiency after treatment. In this work, we successfully synthesized two fullerene derivatives with covalently attached fluorescein and boron dipyrromethene (BODIPY) fluorophore moieties, which exhibited cellular uptake and intracellular localization. While both fluorophores decreased their fluorescence intensity in the vicinity of fullerene, the cellar uptake of the fluorescein-modified fullerene was detected via fluorescence microscopy observations. Moreover, decreases in the fluorescence intensities of the intact fluorescein and BODIPY species were observed when both fluorophores and fullerene coexisted in aqueous media.

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Title: Synthesis of novel fluorescently labeled water-soluble fullerenes and their application to its cellar uptake and distribution properties
Authors: Akiko Hashimoto
Takehiro Yamanaka
Takeji Takamura-Enya
Publication date: 01-12-2017
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 12/2017
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-017-4098-x

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