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Aliphatic [18F]Fluorination Chemistry for Positron Emission Tomography Read chapter Read first chapter

2020 | OriginalPaper | Chapter

TASF Fluorination for Preparing Alkyl Fluorides

Authors : Wenchao Qu, Ximin Li

Published in: Fluorination

Publisher: Springer Singapore

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TASF, a hypervalent silicon reagent [tris(dimethylamino)sulfonium difluorotrimethylsilicate], was first reported by William J. Middleton in 1976 as a catalyst for polymerization and an anhydrous fluoride ion source [11]. The acronym TASF was originally used for both tris(dimethylamino)sulfonium salts and tris(diethylamino)sulfonium salts. Today, TASF refers more often to tris(dimethylamino)sulfonium salt, due to the commercial availability, higher purity, and the advantages of easy formation of crystalline solid, although the ethyl version has better solubility in organic solvents [18‐20]. …

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previous chapter Sulfonyl Fluorides and Their Analogs’ Deoxofluorination
next chapter TBAF Fluorination for Preparing Alkyl Fluorides
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Metadata
Title
TASF Fluorination for Preparing Alkyl Fluorides
Authors
Wenchao Qu
Ximin Li
Copyright Year
2020
Publisher
Springer Singapore
Book
Fluorination

Print ISBN: 978-981-10-3895-2

Electronic ISBN: 978-981-10-3896-9

Copyright Year: 2020

DOI
https://doi.org/10.1007/978-981-10-3896-9_11

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