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Published in:
1987 | OriginalPaper | Chapter
The Involvement of Free Radicals in Chemical Carcinogenesis
Author : William A. Pryor
Published in: Anticarcinogenesis and Radiation Protection
Publisher: Springer US
Included in: Professional Book Archive
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Cancer is a multi-step process, involving three stages that can be operationally distinguished: initiation, promotion and progression. Initiation involves an irreversible alteration of the cellular DNA that permits the transformation of the cell to a non-malignant state. Promotion produces conditions that allow the initiated cell to become malignant, and progression is the growth of the malignant cell to a tumor.