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2015 | OriginalPaper | Chapter

The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction

Authors : Naama Shoham, Natan T. Shaked, Dafna Benayahu, Amit Gefen

Published in: The Mechanobiology of Obesity and Related Diseases

Publisher: Springer International Publishing

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Abstract

This chapter links mechanotransduction phenomena in adipocytes and estrogen function, and suggests a possible mechanism involved in the regulation of fat tissue mass and the onset and progression of obesity. The development, structure and distribution of the white adipose tissues in obesity is reviewed, and so are estrogen production and consumption processes and their potential roles in fat tissue development. We further present mechanotransduction phenomena in adipose cells and tissues, as well as up-to-date literature focusing on mechanical properties of adipose cells and tissues. The novel perspectives in this chapter regarding structure-function relationships in adipose tissues point to a positive feedback loop in which cell and tissue mechanics and estrogen activity play complementary roles, and which ultimately leads to increased fat mass and obesity.

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Title: The Vicious Cycle of Estrogen Consumption and Obesity: The Role of Mechanotransduction
Authors: Naama Shoham
Natan T. Shaked
Dafna Benayahu
Amit Gefen
Publisher: Springer International Publishing
Book: The Mechanobiology of Obesity and Related Diseases
Print ISBN: 978-3-319-09335-2

Electronic ISBN: 978-3-319-09336-9

Copyright Year: 2015
DOI: https://doi.org/10.1007/8415_2014_176