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Journal of Polymer Research
Published in: Journal of Polymer Research 6/2020

01-06-2020 | ORIGINAL PAPER

Two co(II)-based coordination polymers: photocatalytic dye degradation properties and treatment effect against colon cancer by inhibiting IL-6-STAT3 inflammatory signaling pathway

Authors: Xiao-Han Tang, Ren-Yi Zhang, Yun-Chao Yang, Wei-Hui Liu, Li-Hua Zhou

Published in: Journal of Polymer Research | Issue 6/2020

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Abstract

Two novel coordination polymers, formulated as {[Co3(tcpb)2(bimb)(DMF)]}n (1, bimb = 1,4-bis(imidazol-1-ylmethyl)benene, DMF = N,N-dimethylformamide) and {[Co2(tcpb)(bim)](DMF)3·(Dioxane)2·(H2O)3}n (2, Hbim = benzimidazole) were prepared from 1,3,5-tris(4-carbonylphenyloxy)benzene (H3tcpb), a semi-rigid tripodal carboxylate ligand as well as different N-donor ligands under solvothermal conditions. Due to their excellent water stability, complexes 1 and 2 could be used as catalysts for photocatalytic degradation of dye under the UV irradiation. Furthermore, the protective effect of the compound against colitis-associated colon cancer (CAC) was assessed and the particular mechanism was discussed in this study. Firstly, the real time polymerase chain reaction (PCR) was carried out to determine the il-6 and stat3 relative expression in the colon cancer cells after treated by compounds 1 and 2. Then, the percentage of the colon cancer cells after treated by compounds 1 and 2 was detected via Annexin V-FITC/PI apoptosis assay.
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Appendix
Available only for authorised users
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Metadata
Title
Two co(II)-based coordination polymers: photocatalytic dye degradation properties and treatment effect against colon cancer by inhibiting IL-6-STAT3 inflammatory signaling pathway
Authors
Xiao-Han Tang
Ren-Yi Zhang
Yun-Chao Yang
Wei-Hui Liu
Li-Hua Zhou
Publication date
01-06-2020
Publisher
Springer Netherlands
Published in
Journal of Polymer Research / Issue 6/2020
Print ISSN: 1022-9760
Electronic ISSN: 1572-8935
DOI
https://doi.org/10.1007/s10965-020-02129-x

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