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Polymer Bulletin
Published in: Polymer Bulletin 7/2024

07-09-2023 | REVIEW PAPER

Unfolding the potential of nanocomposites as drug carriers and their future scenarios

Authors: Malika Gupta, Rajni Bala, Reecha Madaan, Samrat Chauhan, Rakesh Chawla, Jasleen Kaur, Javad Sharifi-Rad, Daniela Calina

Published in: Polymer Bulletin | Issue 7/2024

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Abstract

Research and development of nanocomposites have become a scientific field of interest in the last decade. These are formed from mixtures of polymers and inorganic solids that combine to form a heterogeneous/hybrid material. They are a type of matrix added to nanoparticles to enhance mechanical properties and additional properties such as electrical, physical and optical properties, followed by size repositioning. These matrices are added in a concentration of about 0.5–2% in the nanocomposite structure. Minor changes in structure, composition, interfacial interactions and components or any exclusive properties may instigate the product. Regarding the method of preparation, the biopolymer and inorganic matrix are grown and polymerized in situ to create a nanocomposite material. The use of nanocomposites has increased its share of interest in biomedical and pharmaceutical sciences, as they can be used as a medicinal carrier due to their morphological properties, such as their surface and rheological properties. This comprehensive review aims to discuss the advantages and disadvantages of nanocomposites, their method of preparation, their types and the utility of nanocomposites as a controlled and targeted delivery system, their use to deliver anticancer, antimicrobial, anti-inflammatory, antidiabetic and cardiovascular drugs, including their prospects.
previous article Topical section “Advanced Testing of Soft Polymer Materials”
next article Recent advancement of nanostructured materials: a compatible therapy of tissue engineering and drug delivery system

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Literature
1.
Vickers NJ (2017) Animal communication: when i’m calling you, will you answer too? Curr Biol 27(14):R713–R715PubMed
2.
Pan D, Wang S, Zhao B, Wu M, Zhang H, Wang Y et al (2009) Li storage properties of disordered graphene nanosheets. Chem Mater 21(14):3136–3142
3.
Awaji H, Choi S-M, Yagi E (2002) Mechanisms of toughening and strengthening in ceramic-based nanocomposites. Mech Mater 34(7):411–422
4.
5.
Mondal J, An JM, Surwase SS, Chakraborty K, Sutradhar SC, Hwang J et al (2022) Carbon nanotube and its derived nanomaterials based high performance biosensing platform. Biosensors 12(9):731PubMedPubMedCentral
6.
7.
Bharadwaj R, Mehrabi A, Hamilton C, Trujillo C, Murga M, Fan R et al (2002) Structure–property relationships in cross-linked polyester–clay nanocomposites. Polymer 43(13):3699–3705
8.
Latif M, Prabhakar M, Nam G-B, Lee D-W, Song J-I (2017) Influence of organomodifiednanoclay on the mechanical and flammability behavior of jute fabric/vinyl ester nanocomposites. Compos Res 30(5):303–309
9.
James Korley LT, Liff SM, Kumar N, McKinley GH, Hammond PT (2006) Preferential association of segment blocks in polyurethane nanocomposites. Macromolecules 39(20):7030–7036
10.
Mirzataheri M (2013) High solid contents copoly (styrene/butyl acrylate)-cloisite 30B nanocomposites. J Nanostruct 3(1):93–101
11.
12.
Korupalli C, Li H, Nguyen N, Mi FL, Chang Y, Lin YJ et al (2021) Conductive materials for healing wounds: their incorporation in electroactive wound dressings, characterization, and perspectives. Adv Healthc Mater 10(6):2001384
13.
Wang Y, Rouabhia M, Lavertu D, Zhang Z (2017) Pulsed electrical stimulation modulates fibroblasts’ behaviour through the Smad signalling pathway. J Tissue Eng Regen Med 11(4):1110–1121PubMed
14.
Park S, Kim H, Makin I, Skiba J, Izadjoo M (2015) Measurement of microelectric potentials in a bioelectrically-active wound care device in the presence of bacteria. J Wound Care 24(1):23–33PubMed
15.
Gul S, Kausar A, Mehmood M, Muhammad B, Jabeen S (2016) Progress on epoxy/polyamide and inorganic nanofiller-based hybrids: introduction, application, and future potential. Polym Plast Technol Eng 55(17):1842–1862
16.
Dorigato A, Pegoretti A, Penati A (2011) Effect of the polymer—filler interaction on the thermo-mechanical response of polyurethane-clay nanocomposites from blocked prepolymer. J Reinf Plast Compos 30(4):325–335
17.
Munhoz T, Fredholm Y, Rivory P, Balvay S, Hartmann D, da Silva P et al (2017) Effect of nanoclay addition on physical, chemical, optical and biological properties of experimental dental resin composites. Dent Mater 33(3):271–279PubMed
18.
19.
Suresh R, Borkar S, Sawant V, Shende V, Dimble S (2010) Nanoclay drug delivery system. Int J Pharm Sci Nanotechnol 3(2):901–906
20.
Riccio P, Zare M, Gomes D, Green D, Stamboulis A (2022) Antimicrobial bioceramics for biomedical applications. Innovative bioceramics in translational medicine I. Springer, pp 159–193
21.
Vaia RA (2022) Polymer nanocomposites open a new dimension for plastics and composites. Air Force Research Lab Wright-Patterson AFB OH Materials and Manufacturing
22.
Sallal HA, Abdul-Hamead AA, Othman FM (2020) Effect of nano powder (Al2O3-CaO) addition on the mechanical properties of the polymer blend matrix composite. Def Technol 16(2):425–431
23.
Zhao J, Stearns LC, Harmer MP, Chan HM, Miller GA, Cook RF (1993) Mechanical behavior of alumina–silicon carbide “nanocomposites.” J Am Ceram Soc 76(2):503–510
24.
Kumar PSR, Mashinini P, Alexis SJ (2022) Metal matrix nanocomposites. Nanotechnology in the automotive industry. Elsevier, pp 199–213
25.
Khan WS, Hamadneh NN, Khan WA (2016) Polymer nanocomposites–synthesis techniques, classification and properties. Sci Appl Tailored Nanostruct
26.
27.
Uddin SM, Mahmud T, Wolf C, Glanz C, Kolaric I, Volkmer C et al (2010) Effect of size and shape of metal particles to improve hardness and electrical properties of carbon nanotube reinforced copper and copper alloy composites. Compos Sci Technol 70(16):2253–2257
28.
Wang J, Deng X, Du S, Cheng F, Li F, Lu L et al (2014) Carbon nanotube reinforced ceramic composites: a review. Int Ceram Rev 63(6):286–289
29.
Thostenson ET, Li C, Chou T-W (2005) Nanocomposites in context. Compos Sci Technol 65(3–4):491–516
30.
Gleiter H (1992) Materials with ultrafine microstructures: retrospectives and perspectives. Nanostruct Mater 1(1):1–19
31.
Braun T, Schubert A, Zsindely S (1997) Nanoscience and nanotecnology on the balance. Scientometrics 38(2):321–325
32.
Hoagland R, Embury J (1980) A treatment of inelastic deformation around a crack tip due to microcracking. J Am Ceram Soc 63(7–8):404–410
33.
Parvej MS, Khan MI, Hossain MK (2022) Preparation of nanoparticle-based polymer composites. Nanoparticle-based polymer composites. Elsevier, pp 55–94
34.
Patnaik A, Patnaik S (2019) Fibres to smart textiles: advances in manufacturing, technologies, and applications. CRC Press, USA
35.
Yilmaz ND (2018) Nanocomposites for smart textiles. Smart textiles: wearable nanotechnology. John Wiley & Sons, pp 211–245
36.
Dyke CA, Tour JM (2004) Covalent functionalization of single-walled carbon nanotubes for materials applications. J Phys Chem A 108(51):11151–11159
37.
Yoon HJ, Yang JH, Zhou Z, Yang SS, Cheng MMC (2011) Carbon dioxide gas sensor using a graphene sheet. Sens Actuators B Chem 157(1):310–313
38.
Pandey JK, Kumar AP, Misra M, Mohanty AK, Drzal LT, Palsingh R (2005) Recent advances in biodegradable nanocomposites. J Nanosci Nanotechnol 5(4):497–526PubMed
39.
Fischer H (2003) Polymer nanocomposites: from fundamental research to specific applications. Mater Sci Eng C 23(6–8):763–772
40.
Nalwa HS (1999) Handbook of nanostructured materials and nanotechnology, five-volume set. Academic Press, USA
41.
Ray SS, Bousmina M (2005) Biodegradable polymers and their layered silicate nanocomposites: in greening the 21st century materials world. Prog Mater Sci 50:962
42.
Kumar A, Chitkara M, Dhillon G, Kumar N (2022) Facile synthesis and structural, microstructural, and dielectric characteristics of SnO2-CeO2 semiconducting binary nanocomposite. ECS Trans 107(1):3739
43.
Kumar A, Kumar N, Chitkara M, Dhillon G (2022) Physicochemical investigations of structurally enriched Sm3+ substituted SnO2 nanocrystals. J Mater Sci Mater Electron 33(8):5283–5296
44.
Kumari PVK, Rao YS, Akhila S (2019) Role of nanocomposites in drug delivery. GSC Biol Pharm Sci 8(3):94–103
45.
Anis A, Faiz S, Luqman M, Poulose AM, Gulrez SK, Shaikh H et al (2013) Developments in shape memory polymeric materials. Polym Plast Technol Eng 52(15):1574–1589
46.
Barage S, Lakkakula J, Sharma A, Roy A, Alghamdi S, Almehmadi M et al (2022) Nanomaterial in food packaging: a comprehensive review. J Nanomater 2022:1–12
47.
Ismail H, Pasbakhsh P, Ahmad Fauzi M, Abu BA (2009) The effect of halloysite nanotubes as a novel nanofiller on curing behaviour, mechanical and microstructural properties of ethylene propylene diene monomer (EPDM) nanocomposites. Polym Plast Technol Eng 48(3):313–323
48.
Kurnoskin A (1992) Epoxy Chelate copper-containing polymers: their chemistry and production. Polym Plast Technol Eng 31(5–6):505–525
49.
Hussain F, Hojjati M, Okamoto M, Gorga RE (2006) Polymer-matrix nanocomposites, processing, manufacturing, and application: an overview. J Compos Mater 40(17):1511–1575
50.
Ščetar M, Siročić AP, Hrnjak-Murgić Z, Galić K (2013) Preparation and properties of low density polyethylene film modified by zeolite and nanoclay. Polym Plast Technol Eng 52(15):1611–1620
51.
Mallakpour S, Zadehnazari A (2013) Thermoplastic vinyl polymers: from macro to nanostructure. Polym Plast Technol Eng 52(14):1423–1466
52.
Ghazanfari S, Faisal HN, Katti KS, Katti DR, Xia W (2022) A coarse-grained model for the mechanical behavior of Na-montmorillonite clay. Langmuir 38(16):4859–4869PubMed
53.
Kawasumi UAM, Kojima Y et al (1993) Swelling behavior of montmorillonite cation exchanged for ω-amino acids by ∊-caprolactam. J Mater Res 8:1174
54.
Alexandre J, Aouad K, Bethoux J, Bouillot J (2000) Recent advances in incisional hernia treatment. Hernia 4(1):S1–S2
55.
Rehab A, Salahuddin N (2005) Nanocomposite materials based on polyurethane intercalated into montmorillonite clay. Mater Sci Eng A 399(1–2):368–376
56.
PinnavaiaTJ LW (1999) Polymer-layered silicatenanocomposites: an overview. Appl Clay Sci 15(1):11–29
57.
Kawasumi M, Hasegawa N, Kato M, Usuki A, Okada A (1997) Preparation and mechanical properties of polypropylene− clay hybrids. Macromolecules 30(20):6333–6338
58.
Kevadiya BD, Joshi GV, Patel HA, Ingole PG, Mody HM, Bajaj HC (2010) Montmorillonite-alginate nanocomposites as a drug delivery system: intercalation and in vitro release of vitamin B1 and vitamin B6. J Biomater Appl 25(2):161–177PubMed
59.
Lee DC, Jang LW (1998) Characterization of epoxy–clay hybrid composite prepared by emulsion polymerization. J Appl Polym Sci 68(12):1997–2005
60.
Jin W, Xingguo C, Mingjun Y, Jiasong H (2001) An investigation on the microcellular structure of polystyrene/LCP blends prepared by using supercritical carbon dioxide. Polymer 42(19):8265–8275
61.
Peppas N (2004) Devices based on intelligent biopolymers for oral protein delivery. Int J Pharm 277(1–2):11–17PubMed
62.
Nair LS, Laurencin CT (2007) Biodegradable polymers as biomaterials. Prog Polym Sci 32(8–9):762–798
63.
Galkina O, Ivanov V, Agafonov A, Seisenbaeva G, Kessler V (2015) Cellulose nanofiber–titania nanocomposites as potential drug delivery systems for dermal applications. J Mater Chem B 3(8):1688–1698PubMed
64.
Benavides S, Villalobos-Carvajal R, Reyes J (2012) Physical, mechanical and antibacterial properties of alginate film: effect of the crosslinking degree and oregano essential oil concentration. J Food Eng 110(2):232–239
65.
Tang Y-F, Du Y-M, Hu X-W, Shi X-W, Kennedy JF (2007) Rheological characterisation of a novel thermosensitive chitosan/poly (vinyl alcohol) blend hydrogel. Carbohyd Polym 67(4):491–499
66.
Kalambur SB, Rizvi SS (2004) Starch-based nanocomposites by reactive extrusion processing. Polym Int 53(10):1413–1416
67.
Famá L, Rojo PG, Bernal C, Goyanes S (2012) Biodegradable starch based nanocomposites with low water vapor permeability and high storage modulus. Carbohyd Polym 87(3):1989–1993
68.
Vishvakarma VK, Kumari K, Patel R, Singh P, Mehrotra GK, Chandra R (2015) Gelatin nanocomposites (GNCs): an efficient drug delivery system. Biomedical applications of natural proteins. Springer, pp 129–148
69.
70.
Thakur S, Chauhan GS, Ahn J-H (2009) Synthesis of acryloyl guar gum and its hydrogel materials for use in the slow release of l-DOPA and l-tyrosine. Carbohyd Polym 76(4):513–520
71.
72.
Vacchi E, Cazzola W (2015) Neverlang: a framework for feature-oriented language development. Comput Lang Syst Struct 43:1–40
73.
Satarkar NS, Hilt JZ (2008) Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release. J Control Release 130(3):246–251PubMed
74.
Zrınyi M, Szabó D, Kilian H-G (1998) Kinetics of the shape change of magnetic field sensitive polymer gels. Polym Gels Netw 6(6):441–454
75.
Zrinyi M (2000) Intelligent polymer gels controlled by magnetic fields. Colloid Polym Sci 278(2):98–103
76.
Patience MX, Genovéva F, Miklós Z (2000) Preparation and responsive properties of magnetically soft poly (N-isopropylacrylamide) gels. Macromolecules 33(5):1716–1719
77.
Ansari MJ, Rajendran RR, Mohanto S, Agarwal U, Panda K, Dhotre K et al (2022) Poly (N-isopropylacrylamide)-based hydrogels for biomedical applications: a review of the state-of-the-art. Gels 8(7):454PubMedPubMedCentral
78.
Shariatinia Z, Zahraee Z (2017) Controlled release of metformin from chitosan–based nanocomposite films containing mesoporous MCM-41 nanoparticles as novel drug delivery systems. J Colloid Interface Sci 501:60–76PubMed
79.
Hur W, Park M, Lee JY, Kim MH, Lee SH, Park CG et al (2016) Bioabsorbable bone plates enabled with local, sustained delivery of alendronate for bone regeneration. J Control Release 222:97–106PubMed
80.
Lee G-S, Park J-H, Shin US, Kim H-W (2011) Direct deposited porous scaffolds of calcium phosphate cement with alginate for drug delivery and bone tissue engineering. Acta Biomater 7(8):3178–3186PubMed
81.
Mobaraki F, Nazari H, Lajevardiyan SA, Hatamie S, Jafary H, Hosseinzadeh S (2022) Synergistic effect of quercetin and cobalt ferrite-graphene oxide-based hyperthermia to inhibit expression of heat shock proteins and induce apoptosis in breast cancer cells. Pharm Sci 28(4):552–563
82.
Zeynabad FB, Salehi R, Mahkam M (2017) Design of pH-responsive antimicrobial nanocomposite as dual drug delivery system for tumor therapy. Appl Clay Sci 141:23–35
83.
Ouyang L, Liu M, Chen K, Liu J, Wang H, Zhu M et al (2022) Recent progress on hydrogen generation from the hydrolysis of light metals and hydrides. J Alloys Compd 910:164831
84.
Chatterjee S, Hui PC, Kan C-W, Wang W (2019) Dual-responsive (pH/temperature) Pluronic F-127 hydrogel drug delivery system for textile-based transdermal therapy. Sci Rep 9(1):1–13
85.
Chatterjee S, Hui PC, Wat E, Kan C-W, Leung P-C, Wang W (2020) Drug delivery system of dual-responsive PF127 hydrogel with polysaccharide-based nano-conjugate for textile-based transdermal therapy. Carbohydr Polym 236:116074PubMed
86.
Xie Y, Liao X, Zhang J, Yang F, Fan Z (2018) Novel chitosan hydrogels reinforced by silver nanoparticles with ultrahigh mechanical and high antibacterial properties for accelerating wound healing. Int J Biol Macromol 119:402–412PubMed
87.
Kuki Á, Nagy L, Zsuga M, Kéki S (2011) Fast identification of phthalic acid esters in poly (vinyl chloride) samples by direct analysis in real time (DART) tandem mass spectrometry. Int J Mass Spectrom 303(2–3):225–228
88.
Zhang J, Liang X, Zhang Y, Shang Q (2016) Fabrication and evaluation of a novel polymeric hydrogel of carboxymethyl chitosan-g-polyacrylic acid (CMC-g-PAA) for oral insulin delivery. RSC Adv 6(58):52858–52867
89.
Turabee MH, Jeong TH, Ramalingam P, Kang JH, Ko YT (2019) N, N, N-trimethyl chitosan embedded in situ Pluronic F127 hydrogel for the treatment of brain tumor. Carbohyd Polym 203:302–309
90.
Fathi M, Alami-Milani M, Geranmayeh MH, Barar J, Erfan-Niya H, Omidi Y (2019) Dual thermo-and pH-sensitive injectable hydrogels of chitosan/(poly (N-isopropylacrylamide-co-itaconic acid)) for doxorubicin delivery in breast cancer. Int J Biol Macromol 128:957–964PubMed
91.
Jamal A, Shahzadi L, Ahtzaz S, Zahid S, Chaudhry AA, ur haudhry I et al (2018) Identification of anti-cancer potential of doxazocin: loading into chitosan based biodegradable hydrogels for on-site delivery to treat cervical cancer. Mater Sci Eng C 82:102–109
Metadata
Title
Unfolding the potential of nanocomposites as drug carriers and their future scenarios
Authors
Malika Gupta
Rajni Bala
Reecha Madaan
Samrat Chauhan
Rakesh Chawla
Jasleen Kaur
Javad Sharifi-Rad
Daniela Calina
Publication date
07-09-2023
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 7/2024
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-023-04987-z

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