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Journal of Materials Science

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05-04-2019 | Materials for life sciences

A doxorubicin and vincristine drug release system based on magnetic PLGA microspheres prepared by coaxial electrospray

Authors: Yajun Tang, He Zhao, Jihang Yao, Zhenhua Zhu, Dahui Sun, Mei Zhang

Published in: Journal of Materials Science | Issue 13/2019

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Abstract

In this study, we demonstrated a novel doxorubicin and vincristine-loaded PLGA magnetic microspheres prepared by coaxial electrospray, as a drug delivery system for osteosarcoma treatment. The results showed that microspheres had an minimum mean diameter of 0.32 ± 0.25 μm and exhibited a spherical shape. The particle size distribution changed obviously with the different dosing ways. The entrapment efficiency was found to be 65.72, 73.6 and 74.14% for different microspheres. In vitro degradation research showed that circular pores appeared gradually on the surface of particles with the increase in time, which accelerated the degradation of microspheres. CCK-8 test showed that the Fe₃O₄@PLGA microspheres without drug loading had almost no side effects, the cytotoxicity of Fe₃O₄@P/(V + D), Fe₃O₄@(P + D)/V and Fe₃O₄@(P + V)/D microspheres increased in turn, and Fe₃O₄@(P + V)/D microspheres with minimum particle size could significantly arrest the growth of osteosarcoma saos-2 cells. Therefore, the drug-loaded magnetic microspheres have good killing effect on osteosarcoma cell lines, which can be used as an ideal targeting treatment for postoperative adjuvant therapy of osteosarcoma.

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Title: A doxorubicin and vincristine drug release system based on magnetic PLGA microspheres prepared by coaxial electrospray
Authors: Yajun Tang
He Zhao
Jihang Yao
Zhenhua Zhu
Dahui Sun
Mei Zhang
Publication date: 05-04-2019
Publisher: Springer US
Published in: Journal of Materials Science / Issue 13/2019
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-019-03575-9

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