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2014 | OriginalPaper | Chapter

70. A New Process for Preparation of Hydroxytyrosol

Authors : Yinghao Gao, Xijuan Liang, Yuanmou Chen, Fei Hu, Weizhu Liu, Peng Yu, Erbing Hua

Published in: Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Publisher: Springer Berlin Heidelberg

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Abstract

Hydroxytyrosol is one of the major natural phenolic compounds, mainly in virgin olive oil and the wastewater generated from olive oil processing. Based on its strong antioxidation, hydroxytyrosol is widely used in medical treatment, food, beauty, and other industries. Its diverse biological activities have for a long time attracted considerable interest of synthetic and pharmacological areas. In this paper, the new process of hydroxytyrosol synthesis has been explored, which starts from catechol protection, followed by Friedel–Crafts reaction with ethyl oxalyl monochloride, then the Wolff-Kishner-Huang reaction and reduction reaction with LAH, and finally deprotection. The target compound was obtained by five-step reaction with an overall yield of 23 %. The title compound was characterized on the basis of 1 H NMR spectral.

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Metadata
Title
A New Process for Preparation of Hydroxytyrosol
Authors
Yinghao Gao
Xijuan Liang
Yuanmou Chen
Fei Hu
Weizhu Liu
Peng Yu
Erbing Hua
Copyright Year
2014
Publisher
Springer Berlin Heidelberg
Book
Proceedings of the 2012 International Conference on Applied Biotechnology (ICAB 2012)

Print ISBN: 978-3-642-37921-5

Electronic ISBN: 978-3-642-37922-2

Copyright Year: 2014

DOI
https://doi.org/10.1007/978-3-642-37922-2_70

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