Top

Published in:

01-03-2022 | Materials for life sciences

A self-coated hollow mesoporous silica nanoparticle for tumor targeting and chemo-photothermal therapy

Authors: Qingni Xu, Cong Chang, Xuelian Wang, Chaohua Li, Yuqi Chen, Yueli Zhang, Mengqi Yin, Yuyang Li, Bei Xiong, Bo Lu

Published in: Journal of Materials Science | Issue 10/2022

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Chemotherapy combined with photothermal therapy, a promising strategy for cancer treatment, has a high potential to control drug release and improve therapeutic efficacy. Inspired by this, a pH/NIR dual-responsive drug delivery system (DOX/HMSN@PDA-HA nanoparticles, simplified as DHPH NPs) based on hollow mesoporous silica nanoparticles (HMSNs) was designed for targeted therapy of tumor, by self-coating polydopamine-modified hyaluronic acid (HA-PDA) layer. Doxorubicin (DOX) was loaded into HMSNs for chemotherapy, while HA-PDA coating acted as photothermal therapy agent with tumor-targeted capability. Characterizations suggest that DHPH nanoparticles have been successfully constructed with excellent drug loading capacity (36.91%) and satisfactory photothermal conversion efficiency (25.74%). Furthermore, in vitro results indicate that DHPH nanoparticles could precisely target human hepatocellular liver carcinoma cells and effectively suppress the tumor cells growth under 808 nm laser irradiation (2 W cm⁻²). Therefore, this study presents a feasible strategy for developing efficient platform for tumor-targeted chemo-photothermal therapy.

previous article Zinc-doped hydroxyapatite and poly(propylene fumarate) nanocomposite scaffold for bone tissue engineering

next article Deformation twinning to dislocation slip transition in single-crystal tantalum under dynamic compression

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Available only for authorised users

He H, Xie H, Chen Y, Li C, Han D, Xu F, Lyu J (2020) Global, regional, and national burdens of bladder cancer in 2017: estimates from the 2017 global burden of disease study. BMC Public Health 20(1):1693. https://doi.org/10.1186/s12889-020-09835-7CrossRef

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F (2021) Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 71(3):209–249. https://doi.org/10.3322/caac.21660CrossRef

Wang ZY, Li ZY, Sun ZL, Wang SR, Ali Z, Zhu S, Liu S, Ren QFS, Wang B, Hou Y (2020) Visualization nanozyme based on tumor microenvironment “unlocking” for intensive combination therapy of breast cancer. Sci Adv 6(48):8733–8743. https://doi.org/10.1126/sciadv.abc8733CrossRef

Song Y, Qu Z, Li J, Shi L, Zhao W, Wang H, Sun T, Jia T, Sun Y (2021) Fabrication of the biomimetic DOX/Au@Pt nanoparticles hybrid nanostructures for the combinational chemo/photothermal cancer therapy. J Alloy Compd 881:160592. https://doi.org/10.1016/j.jallcom.2021.160592CrossRef

Yang D, Xu J, Yang G, Zhou Y, Ji H, Bi H, Gai S, He F, Yang P (2018) Metal-organic frameworks join hands to create an anti-cancer nanoplatform based on 808 nm light driving up-conversion nanoparticles. Chem Eng J 344:363–374. https://doi.org/10.1016/j.cej.2018.03.101CrossRef

Yang G, Tian J, Chen C, Jiang D, Xue Y, Wang C, Gao Y, Zhang W (2019) An oxygen self-sufficient NIR-responsive nanosystem for enhanced PDT and chemotherapy against hypoxic tumors. Chem Sci 10(22):5766–5772. https://doi.org/10.1039/c9sc00985jCrossRef

Liu X, Zhang M, Yan D, Deng G, Wang Q, Li C, Zhao L, Lu J (2020) A smart theranostic agent based on Fe-HPPy@Au/DOX for CT imaging and PTT/chemotherapy/CDT combined anticancer therapy. Biomater Sci 8(15):4067–4072. https://doi.org/10.1039/d0bm00623hCrossRef

Deng Z, Fang C, Ma X, Li X, Zeng YJ, Peng X (2020) One stone two birds: Zr–Fc metal-organic framework nanosheet for synergistic photothermal and chemodynamic cancer therapy. ACS Appl Mater Interfaces 12(18):20321–20330. https://doi.org/10.1021/acsami.0c06648CrossRef

Meng X, Zhang B, Yi Y, Cheng H, Wang B, Liu Y, Gong T, Yang W, Yao Y, Wang H, Bu W (2020) Accurate and real-time temperature monitoring during MR imaging guided PTT. Nano Lett 20(4):2522–2529. https://doi.org/10.1021/acs.nanolett.9b05267CrossRef

10.

Wang K, Cai Z, Fan R, Yang Q, Zhu T, Jiang Z, Ma Y (2020) A tumor-microenvironment-responsive nanomaterial for cancer chemo-photothermal therapy. RSC Adv 10(37):22091–22101. https://doi.org/10.1039/d0ra04171hCrossRef

11.

Wang H, Williams GR, Xie X, Wu M, Wu J, Zhu L-M (2020) Stealth polydopamine-based nanoparticles with red blood cell membrane for the chemo-photothermal therapy of cancer. ACS Appl Bio Mater 3(4):2350–2359. https://doi.org/10.1021/acsabm.0c00094CrossRef

12.

Khafaji M, Zamani M, Golizadeh M, Bavi O (2019) Inorganic nanomaterials for chemo/photothermal therapy: a promising horizon on effective cancer treatment. Biophys Rev 11(3):335–352. https://doi.org/10.1007/s12551-019-00532-3CrossRef

13.

Yu D, Wang Y, Chen J, Liu S, Deng S, Liu C, McCulloch I, Yue W, Cheng D (2021) nCo-delivery of NIR-II semiconducting polymer and pH-sensitive doxorubicin-conjugated prodrug for photothermal/chemotherapy. Acta Biomater. https://doi.org/10.1016/j.actbio.2021.10.009CrossRef

14.

Sun H, Zhang Q, Li J, Peng S, Wang X, Cai R (2021) Near-infrared photoactivated nanomedicines for photothermal synergistic cancer therapy. Nano Today 37:101073. https://doi.org/10.1016/j.nantod.2020.101073CrossRef

15.

Zhang W, Cai K, Li X, Zhang J, Ma Z, Foda MF, Mu Y, Dai X, Han H (2019) Au hollow nanorods-chimeric peptide nanocarrier for NIR-II photothermal therapy and real-time apoptosis imaging for tumor theranostics. Theranostics 9(17):4971–4981. https://doi.org/10.7150/thno.35560CrossRef

16.

Zheng S, Dou P, Jin S, Jiao M, Wang W, Jin Z, Wang Y, Li J, Xu K (2021) Tumor microenvironment/NIR-responsive carbon monoxide delivery with hollow mesoporous CuS nanoparticles for MR imaging guided synergistic therapy. Mater Des 205:109731. https://doi.org/10.1016/j.matdes.2021.109731CrossRef

17.

Chen Q, He S, Zhang F, Cui F, Liu J, Wang M, Wang D, Jin Z, Li C (2020) A versatile Pt–Ce6 nanoplatform as catalase nanozyme and NIR-II photothermal agent for enhanced PDT/PTT tumor therapy. Sci China Mater 64(2):510–530. https://doi.org/10.1007/s40843-020-1431-5CrossRef

18.

Chang M, Hou Z, Wang M, Yang C, Wang R, Li F, Liu D, Peng T, Li C, Lin J (2021) Single-atom Pd nanozyme for ferroptosis-boosted mild-temperature photothermal therapy. Angew Chem 60(23):12971–12979. https://doi.org/10.1002/anie.202101924CrossRef

19.

Chang X, Zhang M, Wang C, Zhang J, Wu H, Yang S (2020) Graphene oxide/BaHoF5/PEG nanocomposite for dual-modal imaging and heat shock protein inhibitor-sensitized tumor photothermal therapy. Carbon 158:372–385. https://doi.org/10.1016/j.carbon.2019.10.105CrossRef

20.

Chen YW, Su YL, Hu SH, Chen SY (2016) Functionalized graphene nanocomposites for enhancing photothermal therapy in tumor treatment. Adv Drug Deliv Rev 105(Pt B):190–204. https://doi.org/10.1016/j.addr.2016.05.022CrossRef

21.

Cai W, Gao H, Chu C, Wang X, Wang J, Zhang P, Lin G, Li W, Liu G, Chen X (2017) Engineering phototheranostic manoscale metal-organic frameworks for multimodal imaging-guided cancer therapy. ACS Appl Mater Interfaces 9(3):2040–2051. https://doi.org/10.1021/acsami.6b11579CrossRef

22.

Pu Y, Zhu Y, Qiao Z, Xin N, Chen S, Sun J, Jin R, Nie Y, Fan H (2021) A Gd-doped polydopamine (PDA)-based theranostic nanoplatform as a strong MR/PA dual-modal imaging agent for PTT/PDT synergistic therapy. J Mater Chem B 9(7):1846–1857. https://doi.org/10.1039/d0tb02725aCrossRef

23.

Lu J, Cai L, Dai Y, Liu Y, Zuo F, Ni C, Shi M, Li J (2021) Polydopamine-based nanoparticles for photothermal therapy/chemotherapy and their synergistic therapy with autophagy inhibitor to promote antitumor treatment. Chem Rec 21(4):781–796. https://doi.org/10.1002/tcr.202000170CrossRef

24.

Fan R, Chen C, Hou H, Chuan D, Mu M, Liu Z, Liang R, Guo G, Xu J (2021) Tumor acidity and near-infrared light responsive dual drug delivery polydopamine-based nanoparticles for chemo-photothermal therapy. Adv Funct Mater 31(18):2009733. https://doi.org/10.1002/adfm.202009733CrossRef

25.

Zhu W, Chen M, Liu Y, Tian Y, Song Z, Song G, Zhang X (2019) A dual factor activated metal-organic framework hybrid nanoplatform for photoacoustic imaging and synergetic photo-chemotherapy. Nanoscale 11(43):20630–20637. https://doi.org/10.1039/c9nr06349hCrossRef

26.

Huang C, Zhang L, Guo Q, Zuo Y, Wang N, Wang H, Kong D, Zhu D, Zhang L (2021) Robust nanovaccine based on polydopamine-coated mesoporous silica nanoparticles for effective photothermal-immunotherapy against melanoma. Adv Funct Mater 31(18):2010637. https://doi.org/10.1002/adfm.202010637CrossRef

27.

Zhang C, Wu D, Lu L, Duan X, Liu J, Xie X, Shuai X, Shen J, Cao Z (2018) Multifunctional hybrid liposome as a theranostic platform for magnetic resonance imaging guided photothermal therapy. ACS Biomater Sci Eng 4(7):2597–2605. https://doi.org/10.1021/acsbiomaterials.8b00176CrossRef

28.

Zhang K, Zhang Y, Meng X, Lu H, Chang H, Dong H, Zhang X (2018) Light-triggered theranostic liposomes for tumor diagnosis and combined photodynamic and hypoxia-activated prodrug therapy. Biomaterials 185:301–309. https://doi.org/10.1016/j.biomaterials.2018.09.033CrossRef

29.

Yang L, Zhang C, Liu J, Huang F, Zhang Y, Liang XJ, Liu J (2020) ICG-conjugated and (125) I-labeled polymeric micelles with high biosafety for multimodality imaging-guidedphotothermal therapy of tumors. Adv Healthc Mater 9(5):e1901616. https://doi.org/10.1002/adhm.201901616CrossRef

30.

Zhong S, Chen C, Yang G, Zhu Y, Cao H, Xu B, Luo Y, Gao Y, Zhang W (2019) Acid-triggered nanoexpansion polymeric micelles for enhanced photodynamic therapy. ACS Appl Mater Interfaces 11(37):33697–33705. https://doi.org/10.1021/acsami.9b12620CrossRef

31.

Shang W, Peng L, Guo P, Hui H, Yang X, Tian J (2020) Metal-organic frameworks as a theranostic nanoplatform for combinatorial chemophotothermal therapy adapted to different administration. ACS Biomater Sci Eng 6(2):1008–1016. https://doi.org/10.1021/acsbiomaterials.9b01075CrossRef

32.

Huang L, Liu J, Gao F, Cheng Q, Lu B, Zheng H, Xu H, Xu P, Zhang X, Zeng X (2018) A dual-responsive, hyaluronic acid targeted drug delivery system based on hollow mesoporous silica nanoparticles for cancer therapy. J Mater Chem B 6(28):4618–4629. https://doi.org/10.1039/c8tb00989aCrossRef

33.

Zhou S, Zhong Q, Wang Y, Hu P, Zhong W, Huang C-B, Yu Z-Q, Ding C-D, Liu H, Fu J (2022) Chemically engineered mesoporous silica nanoparticles-based intelligent delivery systems for theranostic applications in multiple cancerous/non-cancerous diseases. Coord Chem Rev 452:214309. https://doi.org/10.1016/j.ccr.2021.214309CrossRef

34.

Chen Z, Liao T, Wan L, Kuang Y, Liu C, Duan J, Xu X, Xu Z, Jiang B, Li C (2021) Dual-stimuli responsive near-infrared emissive carbon dots/hollow mesoporous silica-based integrated theranostics platform for real-time visualized drug delivery. Nano Res 14(11):4264–4273. https://doi.org/10.1007/s12274-021-3624-4CrossRef

35.

Yan T, He J, Liu R, Liu Z, Cheng J (2020) Chitosan capped pH-responsive hollow mesoporous silica nanoparticles for targeted chemo-photo combination therapy. Carbohydr Polym 231:115706. https://doi.org/10.1016/j.carbpol.2019.115706CrossRef

36.

Ma G, Du X, Zhu J, Xu F, Yu H, Li J (2021) Multi-functionalized dendrimers for targeted co-delivery of sorafenib and paclitaxel in liver cancers. J Drug Deliv Sci Technol 63:102493. https://doi.org/10.1016/j.jddst.2021.102493CrossRef

37.

Zhou Y, Chang C, Liu Z, Zhao Q, Xu Q, Li C, Chen Y, Zhang Y, Lu B (2021) Hyaluronic acid-functionalized hollow mesoporous silica nanoparticles as pH-sensitive nanocarriers for cancer chemo-photodynamic therapy. Langmuir ACS J Surf Colloids 37(8):2619–2628. https://doi.org/10.1021/acs.langmuir.0c03250CrossRef

38.

Sun Q, Bi H, Wang Z, Li C, Wang X, Xu J, Zhu H, Zhao R, He F, Gai S, Yang P (2019) Hyaluronic acid-targeted and pH-responsive drug delivery system based on metal-organic frameworks for efficient antitumor therapy. Biomaterials 223:119473. https://doi.org/10.1016/j.biomaterials.2019.119473CrossRef

39.

Chiesa E, Riva F, Dorati R, Greco A, Ricci S, Pisani S, Patrini M, Modena T, Conti B, Genta I (2020) On-chip synthesis of hyaluronic acid-based nanoparticles for selective inhibition of CD44+ human mesenchymal stem cell proliferation. Pharmaceutics 12(3):260–283. https://doi.org/10.3390/pharmaceutics12030260CrossRef

40.

Yu F, Huang J, Yu Y, Lu Y, Chen Y, Zhang H, Zhou G, Sun Z, Liu J, Sun D, Zhang G, Zou H, Zhong Y (2016) Glutathione-responsive multilayer coated gold nanoparticles for targeted gene delivery. J Biomed Nanotechnol 12(3):503–515. https://doi.org/10.1166/jbn.2016.2177CrossRef

41.

Chen K, Chang C, Liu Z, Zhou Y, Xu Q, Li C, Huang Z, Xu H, Xu P, Lu B (2020) Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy. Colloids Surf B 194:111166. https://doi.org/10.1016/j.colsurfb.2020.111166CrossRef

42.

Liu X, Xie Z, Shi W, He Z, Liu Y, Su H, Sun Y, Ge D (2019) Polynorepinephrine nanoparticles: a novel photothermal nanoagent for chemo-photothermal cancer therapy. ACS Appl Mater Interfaces 11(22):19763–19773. https://doi.org/10.1021/acsami.9b03458CrossRef

43.

Pu XQ, Ju XJ, Zhang L, Cai QW, Liu YQ, Peng HY, Xie R, Wang W, Liu Z, Chu LY (2021) Novel multifunctional stimuli-responsive nanoparticles for synergetic chemo-photothermal therapy of tumors. ACS Appl Mater Interfaces 13(24):28802–28817. https://doi.org/10.1021/acsami.1c05330CrossRef

44.

Jiang A, Liu Y, Ma L, Mao F, Liu L, Zhai X, Zhou J (2019) Biocompatible heat-shock protein inhibitor-delivered flowerlike short-wave infrared nanoprobe for mild temperature-driven highly efficient tumor ablation. ACS Appl Mater Interfaces 11(7):6820–6828. https://doi.org/10.1021/acsami.8b21483CrossRef

Title: A self-coated hollow mesoporous silica nanoparticle for tumor targeting and chemo-photothermal therapy
Authors: Qingni Xu
Cong Chang
Xuelian Wang
Chaohua Li
Yuqi Chen
Yueli Zhang
Mengqi Yin
Yuyang Li
Bei Xiong
Bo Lu
Publication date: 01-03-2022
Publisher: Springer US
Published in: Journal of Materials Science / Issue 10/2022
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-022-07020-2

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Other articles of this Issue 10/2022

Effects of pearlite on corrosion initiation and propagation in weathering steels in marine environments

The binder-free mesoporous CoNi2S4 electrode for high-performance symmetric and asymmetric supercapacitor devices

Synthesis of organobentonite-supported Pd composite catalyst used for the catalytic transfer hydrogenation of polyunsaturated fatty acid methyl ester

Enhanced room-temperature magnetoresistance of hybrid graphene nanosheets produced by a laser-assisted process

Synthesis and evaluation of N,N-dibutylundecenamide as new eco-friendly plasticizer for polyvinyl chloride

The construction of double type II heterostructure from CdS and Ni-MOF-74 with two structures and enhanced mechanism of photocatalytic water splitting

Premium Partners