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01.03.2022 | Materials for life sciences

A self-coated hollow mesoporous silica nanoparticle for tumor targeting and chemo-photothermal therapy

verfasst von: Qingni Xu, Cong Chang, Xuelian Wang, Chaohua Li, Yuqi Chen, Yueli Zhang, Mengqi Yin, Yuyang Li, Bei Xiong, Bo Lu

Erschienen in: Journal of Materials Science | Ausgabe 10/2022

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Abstract

Chemotherapy combined with photothermal therapy, a promising strategy for cancer treatment, has a high potential to control drug release and improve therapeutic efficacy. Inspired by this, a pH/NIR dual-responsive drug delivery system (DOX/HMSN@PDA-HA nanoparticles, simplified as DHPH NPs) based on hollow mesoporous silica nanoparticles (HMSNs) was designed for targeted therapy of tumor, by self-coating polydopamine-modified hyaluronic acid (HA-PDA) layer. Doxorubicin (DOX) was loaded into HMSNs for chemotherapy, while HA-PDA coating acted as photothermal therapy agent with tumor-targeted capability. Characterizations suggest that DHPH nanoparticles have been successfully constructed with excellent drug loading capacity (36.91%) and satisfactory photothermal conversion efficiency (25.74%). Furthermore, in vitro results indicate that DHPH nanoparticles could precisely target human hepatocellular liver carcinoma cells and effectively suppress the tumor cells growth under 808 nm laser irradiation (2 W cm⁻²). Therefore, this study presents a feasible strategy for developing efficient platform for tumor-targeted chemo-photothermal therapy.

Vorheriger Artikel Zinc-doped hydroxyapatite and poly(propylene fumarate) nanocomposite scaffold for bone tissue engineering

Nächster Artikel Deformation twinning to dislocation slip transition in single-crystal tantalum under dynamic compression

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Titel: A self-coated hollow mesoporous silica nanoparticle for tumor targeting and chemo-photothermal therapy
verfasst von: Qingni Xu
Cong Chang
Xuelian Wang
Chaohua Li
Yuqi Chen
Yueli Zhang
Mengqi Yin
Yuyang Li
Bei Xiong
Bo Lu
Publikationsdatum: 01.03.2022
Verlag: Springer US
Erschienen in: Journal of Materials Science / Ausgabe 10/2022
Print ISSN: 0022-2461
Elektronische ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-022-07020-2

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