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Colloid and Polymer Science

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01-10-2009 | Original Contribution

Alginate beads containing pH-sensitive liposomes and glucose oxidase: glucose-sensitive release

Authors: Yeon Ji Hong, Hyeon Yong Lee, Jin-Chul Kim

Published in: Colloid and Polymer Science | Issue 10/2009

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Abstract

Egg PC (EPC) liposomes bearing a copolymer of N-isopropylacrylamide, methacrylic acid, and octadecylacrylate (P(NIPAM-co-MAA-co-ODA)) were prepared as pH-sensitive liposomes. They were embedded in glucose oxidase (GOD)-immobilized alginate beads. The ratio of EPC/GOD/alginate in the beads was 7.8:1.0:140.4, and the beads were added to glucose solutions so that the concentration of GOD was 0.0068 mg/ml. The enzymatic activity of the immobilized GOD was one fifth to half of that of native enzyme. As the glucose concentration increased from 0 to 400 mg/dl, the degree of calcein release increased from 17% to 75%. The acidification induced by the enzymatic reaction would be responsible for the glucose-triggered release.

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Horbett T, Kost J, Ratner B (1983) Swelling behavior of glucose sensitive membranes. Am Chem Soc, Div Polym Chem 24:34–35

Kost J, Horbett T, Ratner B, Singh M (1985) Glucose sensitive membranes containing glucose oxidase: activity, swelling and permeability studies. J Biomed Mater Res 19:1117–1133CrossRef

Albin G, Horbett T, Ratner B (1985) Glucose sensitive membranes for controlled delivery of insulin: insulin transport studies. J Control Release 2:153–164CrossRef

Albin G, Horbett T, Miller S, Ricker N (1987) Theoretical and experimental studies of glucose sensitive membranes. J Control Release 6:267–291CrossRef

Albin G, Horbett T, Ratner B (1990) Glucose-sensitive membranes for controlled release of insulin. In: Kost J (ed) Pulsed and self-regulated drug delivery. CRC, Boca Raton, pp 159–185

Jeong SY, Kim SW, Eenink MJD, Feijen J (1984) Self-regulating insulin delivery systems I. Synthesis and characterization of glycosylated insulin. J Control release 1:57–66CrossRef

Kim SW, Jeong SY, Sato S, McRea JC, Feijen J (1984) Self regulating insulin delivery system — a chemical approach. In: Anderson JM, Kim SW (eds) Recent advances in drug delivery systems. Plenum, New York, pp 123–136

Sato S, Jeong SY, McRea JC, Kim SW (1984) Self-regulating insulin delivery systems II. In vitro studies. J Control Release 1:67–77CrossRef

Sato S, Jeong SY, McRea JC, Kim SW (1984) Glucose stimulated insulin delivery system. Pure Appl Chem 56:1323–1328CrossRef

10.

Jeong SY, Kim SW, Holemberg D, McRea JC (1985) Glucose sensitive membranes for controlled delivery of insulin: insulin transport studies. J Control Release 2:153–164CrossRef

11.

Seminoff L, Kim SW (1990) A self- regulating insulin delivery system based on competitive binding of glucose and glycosylated insulin. In: Kost J (ed) Pulsed and self-regulated drug delivery. CRC, Boca Raton, pp 187–199

12.

Jo S-M, Kim J-C (2009) Glucose-triggered release from liposomes incorporating poly(N -isopropylacrylamide-co-methacrylic acid-co-octadecylacrylate) and glucose oxidase. Colloid Polym Sci 287:379–384CrossRef

13.

Drummond DC, ZM LJC (2000) Current status of pH-sensitive liposomes in drug delivery. Prog Lipid Res 39:409–460CrossRef

14.

Jo S-M, Lee HY, Kim J-C (2008) Glucose-sensitive liposomes incorporating hydrophobically modified glucose oxidase. Lipids 43:937–943CrossRef

15.

Choi J-H, Lee HY, Kim J-C (2008) pH-Sensitivity and air/water interfacial activity of poly(N-isopropylacrylamide-co-methacrylic acid-co-octadecyl acrylate). J Appl Polym Sci 108:3707–3712CrossRef

16.

Choi J-H, Lee HY, Kim J-C (2008) Release behavior of freeze-dried alginate beads containing poly(N-isopropylacrylamide) copolymers. J Appl Polym Sci 110:117–123CrossRef

17.

Cho SM, Lee HY, Kim J-C (2008) Liposomes incorporating hydrophobically modified glucose oxidase. Korean J Chem Eng 25:390CrossRef

18.

Bergmeyer HU, Gawehn K, Grassl M (1974) Methods of enzymatic analysis. Academic, New York

19.

Jeong B, Gutowska A (2002) Lessons from nature: stimuli-responsive polymers and their biomedical applications. Trends Biotechnol 20:305–311CrossRef

20.

Schaeffer HE, Krohn DL (1982) Liposomes in topical drug delivery. Invest Ophth Vis Sci 22:220–227

21.

Gregoriadis G (1984) Liposome technology, Vols. I, II, III. CRC, Boca Raton

22.

New RRC (1990) Introduction. In: New RRC (ed) Liposomes: A practical approach. IRL, New York, pp 1–22

23.

Simoes S, Moreira JN, Fonseca C, Duzgunes N, Pedroso de lima MC (2004) On the formulation of pH-sensitive liposomes with long circulation times. Adv Drug Deliv Rev 56:947–965CrossRef

24.

Coorssen JR, Rand RP (1995) Structural effects of neutral lipids on divalent cation-induced interactions of phosphatidylserine-containing bilayers. Biophys J 68:1009–1018CrossRef

25.

Slepushkin VA, Simões S, Dazin P, Newman MS, Guo LS, Pedroso Lima MC, Düzgünes N (1997) Sterically stabilized pH-sensitive liposomes: intracellular delivery of aqueous contents and prolonged circulation in vivo. J Biol Chem 272:2382–2388CrossRef

26.

Litzinger DC, Huang L (1992) Phosphatidylethanolamine liposomes: drug delivery, gene transfer and immunodiagnostic applications. Biochim Biophys Acta 1113:201–227

27.

Ellens H, Bentz J, Szoka FC (1984) pH-Induced destabilization of phosphatidyl ethanolamine-containing liposomes: role of bilayer contact. Biochemistry 23:1532–1538CrossRef

28.

Cullis PR, Kruijff BD (1979) Lipid polymorphism and the functional roles of lipids in biological membranes. Biochim Biophys Acta 559:399–420

Title: Alginate beads containing pH-sensitive liposomes and glucose oxidase: glucose-sensitive release
Authors: Yeon Ji Hong
Hyeon Yong Lee
Jin-Chul Kim
Publication date: 01-10-2009
Publisher: Springer-Verlag
Published in: Colloid and Polymer Science / Issue 10/2009
Print ISSN: 0303-402X
Electronic ISSN: 1435-1536
DOI: https://doi.org/10.1007/s00396-009-2084-2

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