1986 | OriginalPaper | Chapter
An Uncontrolled Phase II Study of Constant Infusion Vincristine-Adriamycin
Authors : L. Helson, M. A. Castello, E. Arenson, L. Steinherz, S. Groshen
Published in: Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy
Publisher: Springer US
Included in: Professional Book Archive
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The combination of adriamycin and vincristine administered as bolus injections have antitumoral activity in pediatric cases; however there are no published reports of concomitant constant infusion vincristine and adriamycin. Due to their short serum half-life, it seems reasonable that an improvement in their therapeutic index might occur if these drugs were given as a continuous infusion. In support of this, there is published evidence of reduced cardiotoxic effects in adults for adriamycin when it was administered as a constant effusion (1). We considered it reasonable to evaluate the clinical effects of the combination administered as a constant infusion in patients who were considered refractory to these same drugs given as bolus injections.