1986 | OriginalPaper | Buchkapitel
An Uncontrolled Phase II Study of Constant Infusion Vincristine-Adriamycin
verfasst von : L. Helson, M. A. Castello, E. Arenson, L. Steinherz, S. Groshen
Erschienen in: Clinical Applications of Continuous Infusion Chemotherapy and Concomitant Radiation Therapy
Verlag: Springer US
Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.
Wählen Sie Textabschnitte aus um mit Künstlicher Intelligenz passenden Patente zu finden. powered by
Markieren Sie Textabschnitte, um KI-gestützt weitere passende Inhalte zu finden. powered by
The combination of adriamycin and vincristine administered as bolus injections have antitumoral activity in pediatric cases; however there are no published reports of concomitant constant infusion vincristine and adriamycin. Due to their short serum half-life, it seems reasonable that an improvement in their therapeutic index might occur if these drugs were given as a continuous infusion. In support of this, there is published evidence of reduced cardiotoxic effects in adults for adriamycin when it was administered as a constant effusion (1). We considered it reasonable to evaluate the clinical effects of the combination administered as a constant infusion in patients who were considered refractory to these same drugs given as bolus injections.