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Biomaterial-Associated Infection: A Perspective from the Clinic Read chapter Read first chapter

2013 | OriginalPaper | Chapter

12. Animal Models of Orthopedic Implant-Related Infection

Authors : Lorenzo Calabro, Cameron Lutton, Ahmed Fouad Seif El Din, R. Geoff Richards, T. Fintan Moriarty

Published in: Biomaterials Associated Infection

Publisher: Springer New York

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Abstract

Musculoskeletal infection remains a great challenge in orthopedic and trauma surgery. Despite best medical and surgical practice and significant advances in research and development, bone and implant associated infections are still difficult to diagnose, impossible to prevent in all cases and require invasive and debilitating treatment. The development and safe clinical implementation of novel preventative, therapeutic or diagnostic strategies requires the use of animal models of infection, which provide crucial evidence regarding performance, cytocompatibility, biocompatibility, and safety prior to clinical implementation.
Many animal models of musculoskeletal infection have been described in the literature; however, there remains a dearth of fully standardized or universally accepted reference models hindering advancement in the field. The following chapter provides an overview of the animal models available for the study of musculoskeletal infection, the latest advances that are expected to improve them, and some of the most important scientific output achieved using these models.

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previous chapter Infections Associated with Implanted Dental Devices
next chapter Antimicrobial Medical Devices in Preclinical Development and Clinical Use
Glossary
Implant-related Osteomyelitis
Osteomyelitis occurring associated with an ­implant, most commonly prosthetic joint replacements or fracture fixation devices.
Osteomyelitis
Osteomyelitis is an acute or chronic infection of the bone or bone marrow.
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Metadata
Title
Animal Models of Orthopedic Implant-Related Infection
Authors
Lorenzo Calabro
Cameron Lutton
Ahmed Fouad Seif El Din
R. Geoff Richards
T. Fintan Moriarty
Copyright Year
2013
Publisher
Springer New York
Book
Biomaterials Associated Infection

Print ISBN: 978-1-4614-1030-0

Electronic ISBN: 978-1-4614-1031-7

Copyright Year: 2013

DOI
https://doi.org/10.1007/978-1-4614-1031-7_12

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