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Polymer Bulletin
Published in: Polymer Bulletin 2/2019

03-07-2018 | Original Paper

Baicalein-p-sulfonatocalix[n]arenes inclusion complexes: characterization, antioxidant ability and stability

Authors: Jianbin Chao, Miao Xu, Xiaolu Wang, Zhiqiang Guo

Published in: Polymer Bulletin | Issue 2/2019

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Abstract

The baicalein (Ba) is extracted from the roots of traditional Chinese medicine plant, Scutellaria baicalensis Georgi. Ba has attracted more attention for the high medicinal value, but the low oxidation resistance, poor thermal and photostability prevent its application. In this paper, inclusion complexes of Ba and p-sulfonatocalix[n]arenes (SCXn, n = 4, 6, 8) were prepared and characterized. The prepared complexes were characterized by fluorescence spectroscopy, Fourier transform infrared spectroscopy, proton nuclear magnetic resonance spectroscopy (1H NMR), and atomic force microscopy. The fluorescence titration experiment confirmed Ba and SCXn formed inclusion complexes at a stoichiometry of 1:1. A cap-type inclusion mode between the host and guest molecules could infer from 1H NMR spectroscopy. In addition, antioxidant activity, thermal stability and photostability of Ba were enhanced by forming inclusion complexes with SCXn which were favorable to improving the bioavailability of Ba. Finally, toxicity studies showed that the toxicity of these inclusion compounds Ba/SCXn was not remarkably different from that of the Ba, which was advantageous for the application and development of the Ba/SCXn.
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Metadata
Title
Baicalein-p-sulfonatocalix[n]arenes inclusion complexes: characterization, antioxidant ability and stability
Authors
Jianbin Chao
Miao Xu
Xiaolu Wang
Zhiqiang Guo
Publication date
03-07-2018
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 2/2019
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-018-2415-x

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