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Journal of Materials Science
Published in: Journal of Materials Science 12/2018

05-03-2018 | Chemical routes to materials

Biocompatible nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles: synthesis, characterization and magnetic heating efficiency

Authors: P. H. Linh, N. V. Chien, D. D. Dung, P. H. Nam, D. T. Hoa, N. T. N. Anh, L. V. Hong, N. X. Phuc, P. T. Phong

Published in: Journal of Materials Science | Issue 12/2018

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Abstract

In this work, we developed a polymer encapsulation of Fe3O4 nanoparticles as a core–shell nanocluster with different sizes to investigate the cluster structure effect on their magnetic properties and magnetic heating behavior. Well-dispersed nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles were synthesized by microwave-assisted co-precipitation. The cluster sizes were tunable by varying the concentration of polymers used during synthesis. Nanoclusters present superparamagnetic behavior at room temperature with a reduction in saturation magnetization as a consequence of coating layer. The shift of blocking temperature to the higher value with increasing clusters size shows the stronger magnetic interaction in larger magnetic clusters. In a low alternating magnetic field with frequency of 178 Hz and amplitude of 103 Oe, nanoclusters offer a high heating efficiency. A maximum specific absorption rate of 204 W/g is observed in the sample with hydrodynamic size of 53 nm. In vitro cytotoxicity analysis performed on HeLa cells verified that nanoclusters show a good biocompatibility and can be an excellent candidate for applications in hyperthermia cancer treatment.
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Metadata
Title
Biocompatible nanoclusters of O-carboxymethyl chitosan-coated Fe3O4 nanoparticles: synthesis, characterization and magnetic heating efficiency
Authors
P. H. Linh
N. V. Chien
D. D. Dung
P. H. Nam
D. T. Hoa
N. T. N. Anh
L. V. Hong
N. X. Phuc
P. T. Phong
Publication date
05-03-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 12/2018
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-2180-0

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