Skip to main content
Top

2012 | OriginalPaper | Chapter

15. Bt Crops: Past and Future

Authors : Dr. Anais S. Castagnola, Dr. Juan Luis Jurat-Fuentes

Published in: Bacillus thuringiensis Biotechnology

Publisher: Springer Netherlands

Activate our intelligent search to find suitable subject content or patents.

search-config
loading …

Abstract

The development and commercialization of transgenic plants expressing insecticidal toxin genes from the bacterium Bacillus thuringiensis (Bt) has revolutionized agriculture in the past two decades. Development of this revolutionary insect pest control technology was facilitated by the identification and characterization of insecticidal Bt proteins and advancements in plant transformation and genetic engineering. While commercialization of this technology is currently limited to a number of countries, these transgenic “Bt crops” are replacing in most cases conventional crop varieties due to their insect resistance, lower spraying requirements, and higher yields. However, concerns related to the increasing adoption of this technology include gene flow to wild relatives, evolution of resistance in target pests, and unintended effects on the environment. In this chapter, we discuss key events in the history of Bt crop development and summarize current regulations aimed at reducing the risks associated with increased adoption of this technology. By analyzing the history of Bt transgenic crops and the current marketplace trends and issues, we aim to examine the outlook of current and impending Bt crops as well as potential issues that may emerge during their future use.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Springer Professional "Wirtschaft"

Online-Abonnement

Mit Springer Professional "Wirtschaft" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 340 Zeitschriften

aus folgenden Fachgebieten:

  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Versicherung + Risiko




Jetzt Wissensvorsprung sichern!

Literature
go back to reference Aarssen R, Soetaert P, Stam M, Dockx J, Gosselé V, Seurinck J, Reynaerts A, Cornelissen M (1995) cryIA(b) transcript formation in tobacco is inefficient. Plant Mol Biol 28:513–524CrossRef Aarssen R, Soetaert P, Stam M, Dockx J, Gosselé V, Seurinck J, Reynaerts A, Cornelissen M (1995) cryIA(b) transcript formation in tobacco is inefficient. Plant Mol Biol 28:513–524CrossRef
go back to reference Adamczyk JJ Jr, Sumerford DV (2001) Potential factors impacting season-long expression of Cry1Ac in 13 commercial varieties of Bollgard cotton. J Insect Sci 1:13 Adamczyk JJ Jr, Sumerford DV (2001) Potential factors impacting season-long expression of Cry1Ac in 13 commercial varieties of Bollgard cotton. J Insect Sci 1:13
go back to reference Adamczyk JJ Jr, Adams LC, Hardee DD (2001) Field efficacy and seasonal expression profiles for terminal leaves of single and double Bacillus thuringiensis toxin cotton genotypes. J Econ Entomol 94:1589–1593CrossRef Adamczyk JJ Jr, Adams LC, Hardee DD (2001) Field efficacy and seasonal expression profiles for terminal leaves of single and double Bacillus thuringiensis toxin cotton genotypes. J Econ Entomol 94:1589–1593CrossRef
go back to reference Adamczyk JJ Jr, Perera O, Meredith WR (2009) Production of mRNA from the cry1Ac transgene differs among Bollgard lines which correlates to the level of subsequent protein. Transgenic Res 18:143–149CrossRef Adamczyk JJ Jr, Perera O, Meredith WR (2009) Production of mRNA from the cry1Ac transgene differs among Bollgard lines which correlates to the level of subsequent protein. Transgenic Res 18:143–149CrossRef
go back to reference Agaisse H, Lereclus D (1995) How does Bacillus thuringiensis produce so much insecticidal crystal protein? J Bacteriol 177:6027–6032 Agaisse H, Lereclus D (1995) How does Bacillus thuringiensis produce so much insecticidal crystal protein? J Bacteriol 177:6027–6032
go back to reference Andrews RE, Faust RM, Wabiko H, Raymond KC, Bulla LA (1987) The biotechnology of Bacillus thuringiensis. Crit Rev Biotechnol 6:163–232CrossRef Andrews RE, Faust RM, Wabiko H, Raymond KC, Bulla LA (1987) The biotechnology of Bacillus thuringiensis. Crit Rev Biotechnol 6:163–232CrossRef
go back to reference Barton KA, Whiteley HR, Yang NS (1987) Bacillus thuringienis delta-endotoxin expressed in transgenic Nicotiana tabacum provides resistance to lepidopteran insects. Plant Physiol 85:1103–1109CrossRef Barton KA, Whiteley HR, Yang NS (1987) Bacillus thuringienis delta-endotoxin expressed in transgenic Nicotiana tabacum provides resistance to lepidopteran insects. Plant Physiol 85:1103–1109CrossRef
go back to reference Baum JA, Bogaert T, Clinton W, Heck GR, Feldmann P, Ilagan O, Johnson S, Plaetinck G, Munyikwa T, Pleau M, Vaughn T, Roberts J (2007) Control of coleopteran insect pests through RNA interference. Nat Biotechnol 25:1322–1326CrossRef Baum JA, Bogaert T, Clinton W, Heck GR, Feldmann P, Ilagan O, Johnson S, Plaetinck G, Munyikwa T, Pleau M, Vaughn T, Roberts J (2007) Control of coleopteran insect pests through RNA interference. Nat Biotechnol 25:1322–1326CrossRef
go back to reference Benbrook C (2009) Impacts of genetically engineered crops on pesticide use: the first thirteen years. The Organic Center (http://www.organic-center.org), Critical Issue Report: The First Thirteen years, Boulder, CO Benbrook C (2009) Impacts of genetically engineered crops on pesticide use: the first thirteen years. The Organic Center (http://​www.​organic-center.​org), Critical Issue Report: The First Thirteen years, Boulder, CO
go back to reference Betz FS, Hammond BG, Fuchs RL (2000) Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests. Regul Toxicol Pharmacol 32:156–173CrossRef Betz FS, Hammond BG, Fuchs RL (2000) Safety and advantages of Bacillus thuringiensis-protected plants to control insect pests. Regul Toxicol Pharmacol 32:156–173CrossRef
go back to reference Bourguet D, Desquilbet M, Lemarie S (2005) Regulating insect resistance management: the case of non-Bt corn refuges in the US. J Environ Manag 76:210–220CrossRef Bourguet D, Desquilbet M, Lemarie S (2005) Regulating insect resistance management: the case of non-Bt corn refuges in the US. J Environ Manag 76:210–220CrossRef
go back to reference Brookes G, Barfoot P (2009) Global impact of biotech crops: Income and production effects 1996–2007. AgBioForum 12:184–208 Brookes G, Barfoot P (2009) Global impact of biotech crops: Income and production effects 1996–2007. AgBioForum 12:184–208
go back to reference Bulla LA, Kramer KJ, Davidson LI (1977) Characterization of entomocidal parasporal crystal of Bacillus thuringiensis. J Bacteriol 130:375–383 Bulla LA, Kramer KJ, Davidson LI (1977) Characterization of entomocidal parasporal crystal of Bacillus thuringiensis. J Bacteriol 130:375–383
go back to reference Cantamutto M, Poverene M (2007) Genetically modified sunflower release: opportunities and risks. Field Crops Res 101:133–144CrossRef Cantamutto M, Poverene M (2007) Genetically modified sunflower release: opportunities and risks. Field Crops Res 101:133–144CrossRef
go back to reference Carozzi NB, Warren GW, Desai N, Jayne SM, Lotstein R, Rice DA, Evola S, Koziel MG (1992) Expression of a chimeric CaMV 35S Bacillus thuringiensis insecticidal protein gene in transgenic tobacco. Plant Mol Biol 20:539–548CrossRef Carozzi NB, Warren GW, Desai N, Jayne SM, Lotstein R, Rice DA, Evola S, Koziel MG (1992) Expression of a chimeric CaMV 35S Bacillus thuringiensis insecticidal protein gene in transgenic tobacco. Plant Mol Biol 20:539–548CrossRef
go back to reference Carriere Y, Dennehy TJ, Pedersen B, Haller S, Ellers-Kirk C, Antilla L, Liu YB, Willott E, Tabashnik BE (2001) Large-scale management of insect resistance to transgenic cotton in Arizona: can transgenic insecticidal crops be sustained? J Econ Entomol 94:315–325CrossRef Carriere Y, Dennehy TJ, Pedersen B, Haller S, Ellers-Kirk C, Antilla L, Liu YB, Willott E, Tabashnik BE (2001) Large-scale management of insect resistance to transgenic cotton in Arizona: can transgenic insecticidal crops be sustained? J Econ Entomol 94:315–325CrossRef
go back to reference Center for Environmental Risk Assessment (2009) GM Crop Database, International Life Sciences Institute Research Foundation. http://cera-gmc.org/index.php?action = gm_crop_database. Accessed 7 Sept 2011 Center for Environmental Risk Assessment (2009) GM Crop Database, International Life Sciences Institute Research Foundation. http://​cera-gmc.​org/​index.​php?​action = gm_crop_database. Accessed 7 Sept 2011
go back to reference Chen J, Hua G, Jurat-Fuentes JL, Abdullah MA, Adang MJ (2007) Synergism of Bacillus thuringiensis toxins by a fragment of a toxin-binding cadherin. Proc Natl Acad Sci USA 104:13901–13906CrossRef Chen J, Hua G, Jurat-Fuentes JL, Abdullah MA, Adang MJ (2007) Synergism of Bacillus thuringiensis toxins by a fragment of a toxin-binding cadherin. Proc Natl Acad Sci USA 104:13901–13906CrossRef
go back to reference Chen Y, Tian JC, Wang W, Fang Q, Akhtar ZR, Peng YF, Cui H, Guo YY, Song QS, Ye GY (2011) Bt rice expressing Cry1Ab does not stimulate an outbreak of its non-target herbivore, Nilaparvata lugens. Transgenic Res. doi:10.1007/s11248-011-9530-x Chen Y, Tian JC, Wang W, Fang Q, Akhtar ZR, Peng YF, Cui H, Guo YY, Song QS, Ye GY (2011) Bt rice expressing Cry1Ab does not stimulate an outbreak of its non-target herbivore, Nilaparvata lugens. Transgenic Res. doi:10.1007/s11248-011-9530-x
go back to reference Chitkowski RL, Turnipseed SG, Sullivan MJ, Bridges WC (2003) Field and laboratory evaluations of transgenic cottons expressing one or two Bacillus thuringiensis var. kurstaki Berliner proteins for management of noctuid (Lepidoptera) pests. J Econ Entomol 96:755–762CrossRef Chitkowski RL, Turnipseed SG, Sullivan MJ, Bridges WC (2003) Field and laboratory evaluations of transgenic cottons expressing one or two Bacillus thuringiensis var. kurstaki Berliner proteins for management of noctuid (Lepidoptera) pests. J Econ Entomol 96:755–762CrossRef
go back to reference Christensen AH, Sharrock RA, Quail PH (1992) Maize polyubiquitin genes: structure, thermal perturbation of expression and transcript splicing, and promoter activity following transfer to protoplasts by electroporation. Plant Mol Biol 18:675–689CrossRef Christensen AH, Sharrock RA, Quail PH (1992) Maize polyubiquitin genes: structure, thermal perturbation of expression and transcript splicing, and promoter activity following transfer to protoplasts by electroporation. Plant Mol Biol 18:675–689CrossRef
go back to reference Christou P (2002) No credible scientific evidence is presented to support claims that transgenic DNA was introgressed into traditional maize landraces in Oaxaca, Mexico. Transgenic Res 11:III–V Christou P (2002) No credible scientific evidence is presented to support claims that transgenic DNA was introgressed into traditional maize landraces in Oaxaca, Mexico. Transgenic Res 11:III–V
go back to reference Crickmore N, Bone EJ, Williams JA, Ellar DJ (1995) Contribution of the individual components of the d-endotoxin crystal to the mosquitocidal activity of Bacillus thuringiensis subsp. israelensis. FEMS Microbiol Lett 131:249–254 Crickmore N, Bone EJ, Williams JA, Ellar DJ (1995) Contribution of the individual components of the d-endotoxin crystal to the mosquitocidal activity of Bacillus thuringiensis subsp. israelensis. FEMS Microbiol Lett 131:249–254
go back to reference Crickmore N, Zeigler DR, Schnepf E, Van Rie J, Lereclus D, Baum J, Bravo A, Dean DH (2011) Bacillus thuringiensis toxin nomenclature. http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/. Accessed 23 Sept 2011 Crickmore N, Zeigler DR, Schnepf E, Van Rie J, Lereclus D, Baum J, Bravo A, Dean DH (2011) Bacillus thuringiensis toxin nomenclature. http://​www.​lifesci.​sussex.​ac.​uk/​Home/​Neil_​Crickmore/​Bt/​.​ Accessed 23 Sept 2011
go back to reference Cui J, Luo J, Werf WVD, Ma Y, Xia J (2011) Effect of Pyramiding Bt and CpTI Genes on resistance of cotton to Helicoverpa armigera (Lepidoptera: Noctuidae) under laboratory and field conditions. J Econ Entomol 104:673–684CrossRef Cui J, Luo J, Werf WVD, Ma Y, Xia J (2011) Effect of Pyramiding Bt and CpTI Genes on resistance of cotton to Helicoverpa armigera (Lepidoptera: Noctuidae) under laboratory and field conditions. J Econ Entomol 104:673–684CrossRef
go back to reference Daniell H (2002) Molecular strategies for gene containment in transgenic crops. Nat Biotechnol 20:581–586CrossRef Daniell H (2002) Molecular strategies for gene containment in transgenic crops. Nat Biotechnol 20:581–586CrossRef
go back to reference de Barjac H, Bonnefoi A (1968) A classification of strains of Bacillus thuringiensis Berliner with a key to their differentiation. J Invertebr Pathol 11:335–347CrossRef de Barjac H, Bonnefoi A (1968) A classification of strains of Bacillus thuringiensis Berliner with a key to their differentiation. J Invertebr Pathol 11:335–347CrossRef
go back to reference Dhurua S, Gujar GT (2011) Field-evolved resistance to Bt toxin Cry1Ac in the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), from India. Pest Manag Sci 67:898–903CrossRef Dhurua S, Gujar GT (2011) Field-evolved resistance to Bt toxin Cry1Ac in the pink bollworm, Pectinophora gossypiella (Saunders) (Lepidoptera: Gelechiidae), from India. Pest Manag Sci 67:898–903CrossRef
go back to reference Dogan EB, Berry RE, Reed GL, Rossignol PA (1996) Biological parameters of convergent lady beetle (Coleoptera: Coccinellidae) feeding on aphids (Homoptera: Aphididae) on transgenic potato. J Econ Entomol 89:1105–1108 Dogan EB, Berry RE, Reed GL, Rossignol PA (1996) Biological parameters of convergent lady beetle (Coleoptera: Coccinellidae) feeding on aphids (Homoptera: Aphididae) on transgenic potato. J Econ Entomol 89:1105–1108
go back to reference Dowd PF (2000) Indirect reduction of ear molds and associated mycotoxins in Bacillus thuringiensis corn under controlled and open field conditions: utility and limitations. J Econ Entomol 93:1669–1679CrossRef Dowd PF (2000) Indirect reduction of ear molds and associated mycotoxins in Bacillus thuringiensis corn under controlled and open field conditions: utility and limitations. J Econ Entomol 93:1669–1679CrossRef
go back to reference Earl C (1983) Biotechnology regulation- rules for freed organisms planned. Nature 306:5 Earl C (1983) Biotechnology regulation- rules for freed organisms planned. Nature 306:5
go back to reference Estruch JJ, Warren GW, Mullins MA, Nye GJ, Craig JA, Koziel MG (1996) Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects. Proc Natl Acad Sci USA 93:5389–5394CrossRef Estruch JJ, Warren GW, Mullins MA, Nye GJ, Craig JA, Koziel MG (1996) Vip3A, a novel Bacillus thuringiensis vegetative insecticidal protein with a wide spectrum of activities against lepidopteran insects. Proc Natl Acad Sci USA 93:5389–5394CrossRef
go back to reference Estruch JJ, Carozzi NB, Desai N, Duck NB, Warren GW, Koziel MG (1997) Transgenic plants: an emerging approach to pest control. Nat Biotechnol 15:137–141CrossRef Estruch JJ, Carozzi NB, Desai N, Duck NB, Warren GW, Koziel MG (1997) Transgenic plants: an emerging approach to pest control. Nat Biotechnol 15:137–141CrossRef
go back to reference Fernandez-Cornejo J (2004) The seed industry in U.S. agriculture—an exploration of data and information on crop seed markets, regulation, industry structure, and research and development. Agriculture Information Bulletin, U.S. Department of Agriculture, Economic Research Service, Washington Fernandez-Cornejo J (2004) The seed industry in U.S. agriculture—an exploration of data and information on crop seed markets, regulation, industry structure, and research and development. Agriculture Information Bulletin, U.S. Department of Agriculture, Economic Research Service, Washington
go back to reference Fernandez-Cornejo J, McBride WD (2002) Adoption of bioengineered crops. U.S. Department of Agriculture, Economic Research Service, Washington Fernandez-Cornejo J, McBride WD (2002) Adoption of bioengineered crops. U.S. Department of Agriculture, Economic Research Service, Washington
go back to reference Ferré J, Van Rie J (2002) Biochemistry and genetics of insect resistance to Bacillus thuringiensis. Annu Rev Entomol 47:501–533CrossRef Ferré J, Van Rie J (2002) Biochemistry and genetics of insect resistance to Bacillus thuringiensis. Annu Rev Entomol 47:501–533CrossRef
go back to reference Ferré J, Real MD, Van Rie J, Jansens S, Peferoen M (1991) Resistance to the Bacillus thuringiensis bioinsecticide in a field population of Plutella xylostella is due to a change in a midgut membrane receptor. Proc Natl Acad Sci USA 88:5119–5123CrossRef Ferré J, Real MD, Van Rie J, Jansens S, Peferoen M (1991) Resistance to the Bacillus thuringiensis bioinsecticide in a field population of Plutella xylostella is due to a change in a midgut membrane receptor. Proc Natl Acad Sci USA 88:5119–5123CrossRef
go back to reference Fischhoff DA, Bowdish KS, Perlak FJ, Marrone PG, McCormick SM, Niedermeyer JG, Dean DA, Kusano-Kretzmer K, Mayer EJ, Rochester DE, Rogers SG, Fraley RT (1987) Insect tolerant transgenic tomato plants. Nat Biotechnol 5:807–813CrossRef Fischhoff DA, Bowdish KS, Perlak FJ, Marrone PG, McCormick SM, Niedermeyer JG, Dean DA, Kusano-Kretzmer K, Mayer EJ, Rochester DE, Rogers SG, Fraley RT (1987) Insect tolerant transgenic tomato plants. Nat Biotechnol 5:807–813CrossRef
go back to reference Franco-Rivera A, Benintende G, Cozzi J, Baizabal-Aguirre VM, Valdez-Alarcón JJ, López-Meza JE (2004) Molecular characterization of Bacillus thuringiensis strains from Argentina. Antonie Van Leeuwenhoek 86:87–92CrossRef Franco-Rivera A, Benintende G, Cozzi J, Baizabal-Aguirre VM, Valdez-Alarcón JJ, López-Meza JE (2004) Molecular characterization of Bacillus thuringiensis strains from Argentina. Antonie Van Leeuwenhoek 86:87–92CrossRef
go back to reference Gaertner FH, Quick TC, Thompson MA (1993) CellCap: an encapsulation system for insecticidal biotoxin proteins. In: Kim L (ed) Advanced engineered pesticides. Marcel Dekker, Inc., NY Gaertner FH, Quick TC, Thompson MA (1993) CellCap: an encapsulation system for insecticidal biotoxin proteins. In: Kim L (ed) Advanced engineered pesticides. Marcel Dekker, Inc., NY
go back to reference Gao Y, Schafer BW, Collins RA, Herman RA, Xu XP, Gilbert JR, Ni WT, Langer VL, Tagliani LA (2004) Characterization of Cry34Ab1 and Cry35Ab1 insecticidal crystal proteins expressed in transgenic corn plants and Pseudomonas fluorescens. J Agric Food Chem 52:8057–8065CrossRef Gao Y, Schafer BW, Collins RA, Herman RA, Xu XP, Gilbert JR, Ni WT, Langer VL, Tagliani LA (2004) Characterization of Cry34Ab1 and Cry35Ab1 insecticidal crystal proteins expressed in transgenic corn plants and Pseudomonas fluorescens. J Agric Food Chem 52:8057–8065CrossRef
go back to reference Gao Y, Jurat-Fuentes JL, Oppert B, Fabrick JA, Liu C, Gao J, Lei Z (2011) Increased toxicity of Bacillus thuringiensis Cry3Aa against Crioceris quatuordecimpunctata, Phaedon brassicae and Colaphellus bowringi by a Tenebrio molitor cadherin fragment. Pest Manag Sci 67:1076–1081 Gao Y, Jurat-Fuentes JL, Oppert B, Fabrick JA, Liu C, Gao J, Lei Z (2011) Increased toxicity of Bacillus thuringiensis Cry3Aa against Crioceris quatuordecimpunctata, Phaedon brassicae and Colaphellus bowringi by a Tenebrio molitor cadherin fragment. Pest Manag Sci 67:1076–1081
go back to reference Gatehouse AMR, Ferry N, Raemaekers RJM (2002) The case of the monarch butterfly: a verdict is returned. Trends Genet 18:249–251CrossRef Gatehouse AMR, Ferry N, Raemaekers RJM (2002) The case of the monarch butterfly: a verdict is returned. Trends Genet 18:249–251CrossRef
go back to reference Gatehouse AMR, Ferry N, Edwards MG, Bell HA (2011) Insect-resistant biotech crops and their impacts on beneficial arthropods. Philos Trans R Soc Lond B Biol Sci 366:1438–1452CrossRef Gatehouse AMR, Ferry N, Edwards MG, Bell HA (2011) Insect-resistant biotech crops and their impacts on beneficial arthropods. Philos Trans R Soc Lond B Biol Sci 366:1438–1452CrossRef
go back to reference Gordon-Kamm WJ, Spencer TM, Mangano ML, Adams TR, Daines RJ, Start WG, O’Brien JV, Chambers SA, Adams WR Jr, Willetts NG, Rice TB, Mackey CJ, Krueger RW, Kausch AP, Lemaux PG (1990) Transformation of maize cells and regeneration of fertile transgenic plants. Plant Cell Online 2:603–618 Gordon-Kamm WJ, Spencer TM, Mangano ML, Adams TR, Daines RJ, Start WG, O’Brien JV, Chambers SA, Adams WR Jr, Willetts NG, Rice TB, Mackey CJ, Krueger RW, Kausch AP, Lemaux PG (1990) Transformation of maize cells and regeneration of fertile transgenic plants. Plant Cell Online 2:603–618
go back to reference Gould F (1988) Evolutionary biology and genetically engineered crops: consideration of evolutionary theory can aid in crop design. Bioscience 38:26–33CrossRef Gould F (1988) Evolutionary biology and genetically engineered crops: consideration of evolutionary theory can aid in crop design. Bioscience 38:26–33CrossRef
go back to reference Gould F (1998) Sustainability of transgenic insecticidal cultivars: integrating pest genetics and ecology. Annu Rev Entomol 43:701–726CrossRef Gould F (1998) Sustainability of transgenic insecticidal cultivars: integrating pest genetics and ecology. Annu Rev Entomol 43:701–726CrossRef
go back to reference Gray ME (2010) Relevance of traditional integrated pest management (IPM) strategies for commercial corn producers in a transgenic agroecosystem: a bygone era? J Agric Food Chem 59:5852–5858CrossRef Gray ME (2010) Relevance of traditional integrated pest management (IPM) strategies for commercial corn producers in a transgenic agroecosystem: a bygone era? J Agric Food Chem 59:5852–5858CrossRef
go back to reference Hammond BG, Campbell KW, Pilcher CD, Degooyer TA, Robinson AE, McMillen BL, Spangler SM, Riordan SG, Rice LG, Richard JL (2004) Lower fumonisin mycotoxin levels in the grain of Bt corn grown in the United States in 2000–2002. J Agric Food Chem 52:1390–1397CrossRef Hammond BG, Campbell KW, Pilcher CD, Degooyer TA, Robinson AE, McMillen BL, Spangler SM, Riordan SG, Rice LG, Richard JL (2004) Lower fumonisin mycotoxin levels in the grain of Bt corn grown in the United States in 2000–2002. J Agric Food Chem 52:1390–1397CrossRef
go back to reference Hannay CL, Fitz-James P (1955) The protein crystals of Bacillus thuringiensis Berliner. Can J Microbiol 1:694–710CrossRef Hannay CL, Fitz-James P (1955) The protein crystals of Bacillus thuringiensis Berliner. Can J Microbiol 1:694–710CrossRef
go back to reference He SC, Abad AR, Gelvin SB, Mackenzie SA (1996) A cytoplasmic male sterility-associated mitochondrial protein causes pollen disruption in transgenic tobacco. Proc Natl Acad Sci USA 93:11763–11768CrossRef He SC, Abad AR, Gelvin SB, Mackenzie SA (1996) A cytoplasmic male sterility-associated mitochondrial protein causes pollen disruption in transgenic tobacco. Proc Natl Acad Sci USA 93:11763–11768CrossRef
go back to reference Heuberger S, Crowder DW, Brevault T, Tabashnik BE, Carriere Y (2011) Modeling the effects of plant-to-plant gene flow, larval behavior, and refuge size on pest resistance to Bt cotton. Environ Entomol 40:484–495CrossRef Heuberger S, Crowder DW, Brevault T, Tabashnik BE, Carriere Y (2011) Modeling the effects of plant-to-plant gene flow, larval behavior, and refuge size on pest resistance to Bt cotton. Environ Entomol 40:484–495CrossRef
go back to reference Horsch RB (1993) Commercialization of genetically engineered crops. Philos Trans R Soc Lond B Biol Sci 342:287–291CrossRef Horsch RB (1993) Commercialization of genetically engineered crops. Philos Trans R Soc Lond B Biol Sci 342:287–291CrossRef
go back to reference Hutchison WD, Burkness EC, Mitchell PD, Moon RD, Leslie TW, Fleischer SJ, Abrahamson M, Hamilton KL, Steffey KL, Gray ME, Hellmich RL, Kaster LV, Hunt TE, Wright RJ, Pecinovsky K, Rabaey TL, Flood BR, Raun ES (2010) Areawide suppression of European corn borer with Bt maize reaps savings to non-Bt maize growers. Science 330:222–225CrossRef Hutchison WD, Burkness EC, Mitchell PD, Moon RD, Leslie TW, Fleischer SJ, Abrahamson M, Hamilton KL, Steffey KL, Gray ME, Hellmich RL, Kaster LV, Hunt TE, Wright RJ, Pecinovsky K, Rabaey TL, Flood BR, Raun ES (2010) Areawide suppression of European corn borer with Bt maize reaps savings to non-Bt maize growers. Science 330:222–225CrossRef
go back to reference Ives AR, Glaum PR, Ziebarth NL, Andow DA (2011) The evolution of resistance to two-toxin pyramid transgenic crops. Ecol Appl 21:503–515CrossRef Ives AR, Glaum PR, Ziebarth NL, Andow DA (2011) The evolution of resistance to two-toxin pyramid transgenic crops. Ecol Appl 21:503–515CrossRef
go back to reference Jackson RE, Bradley JR Jr, Van Duyn JW, Gould F (2004) Comparative production of Helicoverpa zea (Lepidoptera: Noctuidae) from transgenic cotton expressing either one or two Bacillus thuringiensis proteins with and without insecticide oversprays. J Econ Entomol 97:1719–1725CrossRef Jackson RE, Bradley JR Jr, Van Duyn JW, Gould F (2004) Comparative production of Helicoverpa zea (Lepidoptera: Noctuidae) from transgenic cotton expressing either one or two Bacillus thuringiensis proteins with and without insecticide oversprays. J Econ Entomol 97:1719–1725CrossRef
go back to reference Jansens S, Vliet A van, Dickburt C, Buysse L, Piens C, Saey B, DeWulf A, Gossele V, Paez A, Gobel E, Peferoen M (1997) Transgenic corn expressing a Cry9C insecticidal protein from Bacillus thuringiensis protected from European corn borer damage. Crop Sci 37:1616–1624CrossRef Jansens S, Vliet A van, Dickburt C, Buysse L, Piens C, Saey B, DeWulf A, Gossele V, Paez A, Gobel E, Peferoen M (1997) Transgenic corn expressing a Cry9C insecticidal protein from Bacillus thuringiensis protected from European corn borer damage. Crop Sci 37:1616–1624CrossRef
go back to reference Jayaraman KS (2001) Illegal Bt cotton in India haunts regulators. Nat Biotechnol 19:1090CrossRef Jayaraman KS (2001) Illegal Bt cotton in India haunts regulators. Nat Biotechnol 19:1090CrossRef
go back to reference Jayaraman KS (2002) Poor crop management plagues Bt cotton experiment in India. Nat Biotechnol 20:1069CrossRef Jayaraman KS (2002) Poor crop management plagues Bt cotton experiment in India. Nat Biotechnol 20:1069CrossRef
go back to reference Kaur S (2006) Molecular approaches for identification and construction of novel insecticidal genes for crop protection. World J Microbiol Biotechnol 22:233–253CrossRef Kaur S (2006) Molecular approaches for identification and construction of novel insecticidal genes for crop protection. World J Microbiol Biotechnol 22:233–253CrossRef
go back to reference Kausch AP, Hague J, Oliver M, Li Y, Daniell H, Mascia P, Watrud LS, Stewart CN (2010) Transgenic perennial biofuel feedstocks and strategies for bioconfinement. Biofuels 1:163–176CrossRef Kausch AP, Hague J, Oliver M, Li Y, Daniell H, Mascia P, Watrud LS, Stewart CN (2010) Transgenic perennial biofuel feedstocks and strategies for bioconfinement. Biofuels 1:163–176CrossRef
go back to reference Kay R, Chan A, Daly M, McPherson J (1987) Duplication of CaMV 35S promoter sequences creates a strong enhancer for plant genes. Science 236:1299–1302CrossRef Kay R, Chan A, Daly M, McPherson J (1987) Duplication of CaMV 35S promoter sequences creates a strong enhancer for plant genes. Science 236:1299–1302CrossRef
go back to reference Kershen DL (2006) Health and food safety: the benefits of Bt-corn. Food Drug Law J 61:197–235 Kershen DL (2006) Health and food safety: the benefits of Bt-corn. Food Drug Law J 61:197–235
go back to reference Kim E, Suh S, Park B, Shin K, Kweon S, Han E, Park S-H, Kim Y, Kim J-K (2009) Chloroplast-targeted expression of synthetic cry1Ac in transgenic rice as an alternative strategy for increased pest protection. Planta 230:397–405CrossRef Kim E, Suh S, Park B, Shin K, Kweon S, Han E, Park S-H, Kim Y, Kim J-K (2009) Chloroplast-targeted expression of synthetic cry1Ac in transgenic rice as an alternative strategy for increased pest protection. Planta 230:397–405CrossRef
go back to reference Kota M, Daniell H, Varma S, Garczynski SF, Gould F, Moar WJ (1999) Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects. Proc Natl Acad Sci USA 96:1840–1845CrossRef Kota M, Daniell H, Varma S, Garczynski SF, Gould F, Moar WJ (1999) Overexpression of the Bacillus thuringiensis (Bt) Cry2Aa2 protein in chloroplasts confers resistance to plants against susceptible and Bt-resistant insects. Proc Natl Acad Sci USA 96:1840–1845CrossRef
go back to reference Koziel MG, Beland GL, Bowman C, Carozzi NB, Crenshaw R, Crossland L, Dawson J, Desai N, Hill M, Kadwell S, Launis K, Lewis K, Maddox D, McPherson K, Meghji MR, Merlin E, Rhodes R, Warren GW, Wright M, Evola SV (1993) Field performance of elite transgenic maize plants expressing an insecticidal protein derived from Bacillus thuringiensis. Nat Biotechnol 11:194–200CrossRef Koziel MG, Beland GL, Bowman C, Carozzi NB, Crenshaw R, Crossland L, Dawson J, Desai N, Hill M, Kadwell S, Launis K, Lewis K, Maddox D, McPherson K, Meghji MR, Merlin E, Rhodes R, Warren GW, Wright M, Evola SV (1993) Field performance of elite transgenic maize plants expressing an insecticidal protein derived from Bacillus thuringiensis. Nat Biotechnol 11:194–200CrossRef
go back to reference Koziel MG, Carozzi NB, Desai N, Warren GW, Dawson J, Dunder E, Launis K, Evola SV (1996) Transgenic maize for the control of european corn corer and other maize insect pests. Ann N Y Acad Sci 792:164–171CrossRef Koziel MG, Carozzi NB, Desai N, Warren GW, Dawson J, Dunder E, Launis K, Evola SV (1996) Transgenic maize for the control of european corn corer and other maize insect pests. Ann N Y Acad Sci 792:164–171CrossRef
go back to reference Kronstad JW, Schnepf HE, Whiteley HR (1983) Diversity of locations for Bacillus thuringiensis crystal protein genes. J Bacteriol 154:419–428 Kronstad JW, Schnepf HE, Whiteley HR (1983) Diversity of locations for Bacillus thuringiensis crystal protein genes. J Bacteriol 154:419–428
go back to reference Lampel JS, Canter GL, Dimock MB, Kelly JL, Anderson JJ, Uratani BB, Foulke JS, Turner JT (1994) Integrative cloning, expression, and stability of the cryIA(c) gene from Bacillus thuringiensis subsp. kurstaki in a recombinant strain of Clavibacter xyli subsp. cynodontis. Appl Environ Microbiol 60:501–508 Lampel JS, Canter GL, Dimock MB, Kelly JL, Anderson JJ, Uratani BB, Foulke JS, Turner JT (1994) Integrative cloning, expression, and stability of the cryIA(c) gene from Bacillus thuringiensis subsp. kurstaki in a recombinant strain of Clavibacter xyli subsp. cynodontis. Appl Environ Microbiol 60:501–508
go back to reference Lang A, Otto M (2010) A synthesis of laboratory and field studies on the effects of transgenic Bacillus thuringiensis (Bt) maize on non-target Lepidoptera. Entomol Exp Appl 135:121–134CrossRef Lang A, Otto M (2010) A synthesis of laboratory and field studies on the effects of transgenic Bacillus thuringiensis (Bt) maize on non-target Lepidoptera. Entomol Exp Appl 135:121–134CrossRef
go back to reference Lawo NC, Wackers FL, Romeis J (2009) Indian Bt cotton varieties do not affect the performance of cotton aphids. PLoS One 4:e4804CrossRef Lawo NC, Wackers FL, Romeis J (2009) Indian Bt cotton varieties do not affect the performance of cotton aphids. PLoS One 4:e4804CrossRef
go back to reference Lawson EC, Weiss JD, Thomas PE, Kaniewski WK (2001) NewLeaf Plus (R) Russet Burbank potatoes: replicase-mediated resistance to potato leafroll virus. Mol Breed 7:1–12CrossRef Lawson EC, Weiss JD, Thomas PE, Kaniewski WK (2001) NewLeaf Plus (R) Russet Burbank potatoes: replicase-mediated resistance to potato leafroll virus. Mol Breed 7:1–12CrossRef
go back to reference Li Y, Meissle M, Romeis J (2008) Consumption of Bt maize pollen expressing Cry1Ab or Cry3Bb1 does not harm adult green lacewings, Chrysoperla carnea (Neuroptera: Chrysopidae). PLoS One 3:e2909CrossRef Li Y, Meissle M, Romeis J (2008) Consumption of Bt maize pollen expressing Cry1Ab or Cry3Bb1 does not harm adult green lacewings, Chrysoperla carnea (Neuroptera: Chrysopidae). PLoS One 3:e2909CrossRef
go back to reference Liu W (2010) Do genetically modified plants impact arbuscular mycorrhizal fungi? Ecotoxicology 19:229–238CrossRef Liu W (2010) Do genetically modified plants impact arbuscular mycorrhizal fungi? Ecotoxicology 19:229–238CrossRef
go back to reference Liu CW, Lin CC, Yiu JC, Chen JJW, Tseng MJ (2008) Expression of a Bacillus thuringiensis toxin (cry1Ab) gene in cabbage (Brassica oleracea L. var. capitata L.) chloroplasts confers high insecticidal efficacy against Plutella xylostella. Theor Appl Genet 117:75–88CrossRef Liu CW, Lin CC, Yiu JC, Chen JJW, Tseng MJ (2008) Expression of a Bacillus thuringiensis toxin (cry1Ab) gene in cabbage (Brassica oleracea L. var. capitata L.) chloroplasts confers high insecticidal efficacy against Plutella xylostella. Theor Appl Genet 117:75–88CrossRef
go back to reference Llewellyn DJ, Mares CL, Fitt GP (2007) Field performance and seasonal changes in the efficacy against Helicoverpa armigera (Hubner) of transgenic cotton expressing the insecticidal protein Vip3A. Agric For Entomol 9:93–101CrossRef Llewellyn DJ, Mares CL, Fitt GP (2007) Field performance and seasonal changes in the efficacy against Helicoverpa armigera (Hubner) of transgenic cotton expressing the insecticidal protein Vip3A. Agric For Entomol 9:93–101CrossRef
go back to reference Long N, Bottoms J, Meghji M, Hart H, Que Q, Pulliam D (2007) Corn Event MIR162. United States Patent US 20090300784 A1, 15 July 2009 Long N, Bottoms J, Meghji M, Hart H, Que Q, Pulliam D (2007) Corn Event MIR162. United States Patent US 20090300784 A1, 15 July 2009
go back to reference Losey JE, Rayor LS, Carter ME (1999) Transgenic pollen harms monarch larvae. Nature 399:214CrossRef Losey JE, Rayor LS, Carter ME (1999) Transgenic pollen harms monarch larvae. Nature 399:214CrossRef
go back to reference Lovei GL, Andow DA, Arpaia S (2009) Transgenic insecticidal crops and natural enemies: a detailed review of laboratory studies. Environ Entomol 38:293–306CrossRef Lovei GL, Andow DA, Arpaia S (2009) Transgenic insecticidal crops and natural enemies: a detailed review of laboratory studies. Environ Entomol 38:293–306CrossRef
go back to reference Lu Y, Wu K, Jiang Y, Xia B, Li P, Feng H, Wyckhuys KA, Guo Y (2010) Mirid bug outbreaks in multiple crops correlated with wide-scale adoption of Bt cotton in China. Science 328:1151–1154CrossRef Lu Y, Wu K, Jiang Y, Xia B, Li P, Feng H, Wyckhuys KA, Guo Y (2010) Mirid bug outbreaks in multiple crops correlated with wide-scale adoption of Bt cotton in China. Science 328:1151–1154CrossRef
go back to reference Luo KM, Duan H, Zhao DG, Zheng XL, Deng W, Chen YQ, Stewart CN, McAvoy R, Jiang XN, Wu YH, He AG, Pei Y, Li Y (2007) ‘GM-gene-deletor’: fused loxP-FRT recognition sequences dramatically improve the efficiency of FLP or CRE recombinase on transgene excision from pollen and seed of tobacco plants. Plant Biotechnol J 5:263–274CrossRef Luo KM, Duan H, Zhao DG, Zheng XL, Deng W, Chen YQ, Stewart CN, McAvoy R, Jiang XN, Wu YH, He AG, Pei Y, Li Y (2007) ‘GM-gene-deletor’: fused loxP-FRT recognition sequences dramatically improve the efficiency of FLP or CRE recombinase on transgene excision from pollen and seed of tobacco plants. Plant Biotechnol J 5:263–274CrossRef
go back to reference Martin MA, Hyde J (2001) Economic considerations for the adoption of transgenic crops: the case of Bt corn. J Nematol 33:173–177 Martin MA, Hyde J (2001) Economic considerations for the adoption of transgenic crops: the case of Bt corn. J Nematol 33:173–177
go back to reference Martinez-Ramirez AC, Gould F, Ferre J (1999) Histopathological effects and growth reduction in a susceptible and a resistant strain of Heliothis virescens (Lepidoptera: Noctuidae) caused by sublethal doses of pure Cry1A crystal proteins from Bacillus thuringiensis. Biocontrol Sci Technol 9:239–246CrossRef Martinez-Ramirez AC, Gould F, Ferre J (1999) Histopathological effects and growth reduction in a susceptible and a resistant strain of Heliothis virescens (Lepidoptera: Noctuidae) caused by sublethal doses of pure Cry1A crystal proteins from Bacillus thuringiensis. Biocontrol Sci Technol 9:239–246CrossRef
go back to reference Marvier M, McCreedy C, Regetz J, Kareiva P (2007) A meta-analysis of effects of Bt cotton and maize on nontarget invertebrates. Science 316:1475–1477CrossRef Marvier M, McCreedy C, Regetz J, Kareiva P (2007) A meta-analysis of effects of Bt cotton and maize on nontarget invertebrates. Science 316:1475–1477CrossRef
go back to reference Matten SR, Lewis PI, Tomimatsu G, Sutherland DWS, Anderson N, ColvinSnyder TL (1996) The US Environmental Protection Agency’s role in pesticide resistance management. In: Brown TM (ed) Molecular genetics and evolution of pesticide resistance. Amer Chemical Soc, Washington Matten SR, Lewis PI, Tomimatsu G, Sutherland DWS, Anderson N, ColvinSnyder TL (1996) The US Environmental Protection Agency’s role in pesticide resistance management. In: Brown TM (ed) Molecular genetics and evolution of pesticide resistance. Amer Chemical Soc, Washington
go back to reference McBride KE, Svab Z, Schaaf DJ, Hogan PS, Stalker DM, Maliga P (1995) Amplification of a Chimeric Bacillus gene in chloroplasts leads to an extraordinary level of an insecticidal protein in tobacco. Nat Biotechnol 13:362–365CrossRef McBride KE, Svab Z, Schaaf DJ, Hogan PS, Stalker DM, Maliga P (1995) Amplification of a Chimeric Bacillus gene in chloroplasts leads to an extraordinary level of an insecticidal protein in tobacco. Nat Biotechnol 13:362–365CrossRef
go back to reference Mulder C, Wouterse M, Raubuch M, Roelofs W, Rutgers M (2006) Can transgenic maize affect soil microbial communities? PLoS Comput Biol 2:e128CrossRef Mulder C, Wouterse M, Raubuch M, Roelofs W, Rutgers M (2006) Can transgenic maize affect soil microbial communities? PLoS Comput Biol 2:e128CrossRef
go back to reference Murray EE, Stock C, Eberle M, Sekar V, Rocheleau TA, Adang MJ (1991) Analysis of unstable RNA transcripts of insecticidal crystal protein genes of Bacilus thuringiensis in transgenic plants and electroporated protoplasts. Plant Mol Biol 16:1035–1050CrossRef Murray EE, Stock C, Eberle M, Sekar V, Rocheleau TA, Adang MJ (1991) Analysis of unstable RNA transcripts of insecticidal crystal protein genes of Bacilus thuringiensis in transgenic plants and electroporated protoplasts. Plant Mol Biol 16:1035–1050CrossRef
go back to reference Naranjo SE (2009) Impacts of Bt crops on non-target invertebrates and insecticide use patterns. In: CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, CABI, Wallingford, UK Naranjo SE (2009) Impacts of Bt crops on non-target invertebrates and insecticide use patterns. In: CAB Reviews: Perspectives in Agriculture, Veterinary Science, Nutrition and Natural Resources, CABI, Wallingford, UK
go back to reference Obukowicz MG, Perlak FJ, Kusano-Kretzmer K, Mayer EJ, Watrud LS (1986) Integration of the delta-endotoxin gene of Bacillus thuringiensis into the chromosome of root-colonizing strains of pseudomonads using Tn5. Gene 45:327–331CrossRef Obukowicz MG, Perlak FJ, Kusano-Kretzmer K, Mayer EJ, Watrud LS (1986) Integration of the delta-endotoxin gene of Bacillus thuringiensis into the chromosome of root-colonizing strains of pseudomonads using Tn5. Gene 45:327–331CrossRef
go back to reference Oliveira AP, Pampulha ME, Bennett JP (2008) A two-year field study with transgenic Bacillus thuringiensis maize: effects on soil microorganisms. Sci Total Environ 405:351–357CrossRef Oliveira AP, Pampulha ME, Bennett JP (2008) A two-year field study with transgenic Bacillus thuringiensis maize: effects on soil microorganisms. Sci Total Environ 405:351–357CrossRef
go back to reference Oppert B, Kramer KJ, Beeman RW, Johnson D, McGaughey WH (1997) Proteinase-mediated insect resistance to Bacillus thuringiensis toxins. J Biol Chem 272:23473–23476CrossRef Oppert B, Kramer KJ, Beeman RW, Johnson D, McGaughey WH (1997) Proteinase-mediated insect resistance to Bacillus thuringiensis toxins. J Biol Chem 272:23473–23476CrossRef
go back to reference Pan ZQ, Onstad DW, Nowatzki TM, Stanley BH, Meinke LJ, Flexner JL (2011) Western corn rootworm (Coleoptera: Chrysomelidae) dispersal and adaptation to single-toxin transgenic corn deployed with block or blended refuge. Environ Entomol 40:964–978CrossRef Pan ZQ, Onstad DW, Nowatzki TM, Stanley BH, Meinke LJ, Flexner JL (2011) Western corn rootworm (Coleoptera: Chrysomelidae) dispersal and adaptation to single-toxin transgenic corn deployed with block or blended refuge. Environ Entomol 40:964–978CrossRef
go back to reference Perlak FJ, Deaton RW, Armstrong TA, Fuchs RL, Sims SR, Greenplate JT, Fischhoff DA (1990) Insect resistant cotton plants. Nat Biotechnol 8:939–943CrossRef Perlak FJ, Deaton RW, Armstrong TA, Fuchs RL, Sims SR, Greenplate JT, Fischhoff DA (1990) Insect resistant cotton plants. Nat Biotechnol 8:939–943CrossRef
go back to reference Perlak FJ, Fuchs RL, Dean DA, McPherson SL, Fischhoff DA (1991) Modification of the coding sequence enhances plant expression of insect control protein genes. Proc Natl Acad Sci USA 88:3324–3328CrossRef Perlak FJ, Fuchs RL, Dean DA, McPherson SL, Fischhoff DA (1991) Modification of the coding sequence enhances plant expression of insect control protein genes. Proc Natl Acad Sci USA 88:3324–3328CrossRef
go back to reference Perlak FJ, Stone TB, Muskopf YM, Petersen LJ, Parker GB, McPherson SA, Wyman J, Love S, Reed G, Biever D et al (1993) Genetically improved potatoes: protection from damage by Colorado potato beetles. Plant Mol Biol 22:313–321CrossRef Perlak FJ, Stone TB, Muskopf YM, Petersen LJ, Parker GB, McPherson SA, Wyman J, Love S, Reed G, Biever D et al (1993) Genetically improved potatoes: protection from damage by Colorado potato beetles. Plant Mol Biol 22:313–321CrossRef
go back to reference Pitt G (2003) Implementation and impact of transgenic Bt cottons in Australia. ICAC Recorder 21:14–19 Pitt G (2003) Implementation and impact of transgenic Bt cottons in Australia. ICAC Recorder 21:14–19
go back to reference Pray CE, Huang J, Hu R, Rozelle S (2002) Five years of Bt cotton in China—the benefits continue. Plant J 31:423–430CrossRef Pray CE, Huang J, Hu R, Rozelle S (2002) Five years of Bt cotton in China—the benefits continue. Plant J 31:423–430CrossRef
go back to reference Qaim M, Zilberman D (2003) Yield effects of genetically modified crops in developing countries. Science 299:900–902CrossRef Qaim M, Zilberman D (2003) Yield effects of genetically modified crops in developing countries. Science 299:900–902CrossRef
go back to reference Qiao F, Huang J, Rozelle S, Wilen J (2010) Natural refuge crops, buildup of resistance, and zero-refuge strategy for Bt cotton in China. Sci China Life Sci 53:1227–1238CrossRef Qiao F, Huang J, Rozelle S, Wilen J (2010) Natural refuge crops, buildup of resistance, and zero-refuge strategy for Bt cotton in China. Sci China Life Sci 53:1227–1238CrossRef
go back to reference Quist D, Chapela IH (2001) Transgenic DNA introgressed into traditional maize landraces in Oaxaca, Mexico. Nature 414:541–543CrossRef Quist D, Chapela IH (2001) Transgenic DNA introgressed into traditional maize landraces in Oaxaca, Mexico. Nature 414:541–543CrossRef
go back to reference Rodrigo-Simon A, Maagd RA de, Avilla C, Bakker PL, Molthoff J, Gonzalez-Zamora JE, Ferre J (2006) Lack of detrimental effects of Bacillus thuringiensis Cry toxins on the insect predator Chrysoperla carnea: a toxicological, histopathological, and biochemical analysis. Appl Environ Microbiol 72:1595–1603CrossRef Rodrigo-Simon A, Maagd RA de, Avilla C, Bakker PL, Molthoff J, Gonzalez-Zamora JE, Ferre J (2006) Lack of detrimental effects of Bacillus thuringiensis Cry toxins on the insect predator Chrysoperla carnea: a toxicological, histopathological, and biochemical analysis. Appl Environ Microbiol 72:1595–1603CrossRef
go back to reference Romeis J, Dutton A, Bigler F (2004) Bacillus thuringiensis toxin (Cry1Ab) has no direct effect on larvae of the green lacewing Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae). J Insect Physiol 50:175–183CrossRef Romeis J, Dutton A, Bigler F (2004) Bacillus thuringiensis toxin (Cry1Ab) has no direct effect on larvae of the green lacewing Chrysoperla carnea (Stephens) (Neuroptera: Chrysopidae). J Insect Physiol 50:175–183CrossRef
go back to reference Rong J, Lu BR, Song Z, Su J, Snow AA, Zhang X, Sun S, Chen R, Wang F (2007) Dramatic reduction of crop-to-crop gene flow within a short distance from transgenic rice fields. New Phytol 173:346–353CrossRef Rong J, Lu BR, Song Z, Su J, Snow AA, Zhang X, Sun S, Chen R, Wang F (2007) Dramatic reduction of crop-to-crop gene flow within a short distance from transgenic rice fields. New Phytol 173:346–353CrossRef
go back to reference Roush RT (1998) Two-toxins strategies for management of insecticidal transgenic crops: can pyramiding succeed where pesticide mixtures have not? Philos Trans R Soc Lond B Biol Sci 353:1777–1786CrossRef Roush RT (1998) Two-toxins strategies for management of insecticidal transgenic crops: can pyramiding succeed where pesticide mixtures have not? Philos Trans R Soc Lond B Biol Sci 353:1777–1786CrossRef
go back to reference Salamitou S, Agaisse H, Bravo A, Lereclus D (1996) Genetic analysis of cryIIIA gene expression in Bacillus thuringiensis. Microbiology 142:2049–2055CrossRef Salamitou S, Agaisse H, Bravo A, Lereclus D (1996) Genetic analysis of cryIIIA gene expression in Bacillus thuringiensis. Microbiology 142:2049–2055CrossRef
go back to reference Sanahuja G, Banakar R, Twyman RM, Capell T, Christou P (2011) Bacillus thuringiensis: a century of research, development and commercial applications. Plant Biotechnol J 9:283–300CrossRef Sanahuja G, Banakar R, Twyman RM, Capell T, Christou P (2011) Bacillus thuringiensis: a century of research, development and commercial applications. Plant Biotechnol J 9:283–300CrossRef
go back to reference Sanchis V (2010) From microbial sprays to insect-resistant transgenic plants: history of the biospesticide Bacillus thuringiensis. A review. Agron Sustain Dev. 31:217–231 Sanchis V (2010) From microbial sprays to insect-resistant transgenic plants: history of the biospesticide Bacillus thuringiensis. A review. Agron Sustain Dev. 31:217–231
go back to reference Schnepf HE, Whiteley HR (1981) Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli. Proc Natl Acad Sci USA 78:2893–2897CrossRef Schnepf HE, Whiteley HR (1981) Cloning and expression of the Bacillus thuringiensis crystal protein gene in Escherichia coli. Proc Natl Acad Sci USA 78:2893–2897CrossRef
go back to reference Sears MK, Hellmich RL, Stanley-Horn DE, Oberhauser KS, Pleasants JM, Mattila HR, Siegfried BD, Dively GP (2001) Impact of Bt corn pollen on monarch butterfly populations: a risk assessment. Proc Natl Acad Sci USA 98:11937–11942CrossRef Sears MK, Hellmich RL, Stanley-Horn DE, Oberhauser KS, Pleasants JM, Mattila HR, Siegfried BD, Dively GP (2001) Impact of Bt corn pollen on monarch butterfly populations: a risk assessment. Proc Natl Acad Sci USA 98:11937–11942CrossRef
go back to reference Seetharam S (2010) Should the Bt brinjal controversy concern healthcare professionals and bioethicists? Indian J Med Ethics 7:9–12 Seetharam S (2010) Should the Bt brinjal controversy concern healthcare professionals and bioethicists? Indian J Med Ethics 7:9–12
go back to reference Shelton A, Sears M (2001) The monarch butterfly controversy: scientific interpretations of a phenomenon. Plant J 27:483–488CrossRef Shelton A, Sears M (2001) The monarch butterfly controversy: scientific interpretations of a phenomenon. Plant J 27:483–488CrossRef
go back to reference Shelton AM, Zhao J-Z, Roush RT (2002) Economic, ecological, food safety, and social consequences of the deployment of Bt transgenic plants. Annu Rev Entomol 47:845–881CrossRef Shelton AM, Zhao J-Z, Roush RT (2002) Economic, ecological, food safety, and social consequences of the deployment of Bt transgenic plants. Annu Rev Entomol 47:845–881CrossRef
go back to reference Sheridan C (2009) Report claims no yield advantage for Bt crops. Nat Biotechnol 27:588–589CrossRef Sheridan C (2009) Report claims no yield advantage for Bt crops. Nat Biotechnol 27:588–589CrossRef
go back to reference Shivakumar AG, Vanags RI, Wilcox DR, Katz L, Vary PS, Fox JL (1989) Gene dosage effect on the expression of the delta-endotoxin genes of Bacillus thuringiensis subsp. kurstaki in Bacillus subtilis and Bacillus megaterium. Gene 79:21–31CrossRef Shivakumar AG, Vanags RI, Wilcox DR, Katz L, Vary PS, Fox JL (1989) Gene dosage effect on the expression of the delta-endotoxin genes of Bacillus thuringiensis subsp. kurstaki in Bacillus subtilis and Bacillus megaterium. Gene 79:21–31CrossRef
go back to reference Skøt L, Harrison SP, Nath A, Mytton LR, Clifford BC (1990) Expression of insecticidal activity in Rhizobium containing the d-endotoxin gene cloned from Bacillus thuringiensis subsp. tenebrionis. Plant Soil 127:285–295CrossRef Skøt L, Harrison SP, Nath A, Mytton LR, Clifford BC (1990) Expression of insecticidal activity in Rhizobium containing the d-endotoxin gene cloned from Bacillus thuringiensis subsp. tenebrionis. Plant Soil 127:285–295CrossRef
go back to reference Soberón M, Pardo-López L, López I, Gómez I, Tabashnik BE, Bravo A (2007) Engineering modified Bt toxins to counter insect resistance. Science 318:1640–1642CrossRef Soberón M, Pardo-López L, López I, Gómez I, Tabashnik BE, Bravo A (2007) Engineering modified Bt toxins to counter insect resistance. Science 318:1640–1642CrossRef
go back to reference Stark DM (1997) Risk assessment and criteria for commercial launch of transgenic plants. Proceedings of the 3rd Ifgene Workshop, Dornach, Switzerland Stark DM (1997) Risk assessment and criteria for commercial launch of transgenic plants. Proceedings of the 3rd Ifgene Workshop, Dornach, Switzerland
go back to reference Stewart SD, Adamczyk JJ Jr, Knighten KS, Davis FM (2001) Impact of Bt cottons expressing one or two insecticidal proteins of Bacillus thuringiensis Berliner on growth and survival of noctuid (Lepidoptera) larvae. J Econ Entomol 94:752–760CrossRef Stewart SD, Adamczyk JJ Jr, Knighten KS, Davis FM (2001) Impact of Bt cottons expressing one or two insecticidal proteins of Bacillus thuringiensis Berliner on growth and survival of noctuid (Lepidoptera) larvae. J Econ Entomol 94:752–760CrossRef
go back to reference Storer NP, Babcock JM, Schlenz M, Meade T, Thompson GD, Bing JW, Huckaba RM (2010) Discovery and characterization of field resistance to Bt maize: Spodoptera frugiperda (Lepidoptera: Noctuidae) in Puerto Rico. J Econ Entomol 103:1031–1038CrossRef Storer NP, Babcock JM, Schlenz M, Meade T, Thompson GD, Bing JW, Huckaba RM (2010) Discovery and characterization of field resistance to Bt maize: Spodoptera frugiperda (Lepidoptera: Noctuidae) in Puerto Rico. J Econ Entomol 103:1031–1038CrossRef
go back to reference Tabashnik BE (1989) Managing resistance with multiple pesticide tactics: theory, evidence, and recommendations. J Econ Entomol 82:1263–1269 Tabashnik BE (1989) Managing resistance with multiple pesticide tactics: theory, evidence, and recommendations. J Econ Entomol 82:1263–1269
go back to reference Tabashnik BE, Van Rensburg JB, Carrière Y (2009) Field-evolved insect resistance to Bt crops: definition, theory, and data. J Econ Entomol 102:2011–2025CrossRef Tabashnik BE, Van Rensburg JB, Carrière Y (2009) Field-evolved insect resistance to Bt crops: definition, theory, and data. J Econ Entomol 102:2011–2025CrossRef
go back to reference Tank JL, Rosi-Marshall EJ, Royer TV, Whiles MR, Griffiths NA, Frauendorf TC, Treering DJ (2010) Occurrence of maize detritus and a transgenic insecticidal protein (Cry1Ab) within the stream network of an agricultural landscape. Proc Natl Acad Sci USA 107:17645–17650CrossRef Tank JL, Rosi-Marshall EJ, Royer TV, Whiles MR, Griffiths NA, Frauendorf TC, Treering DJ (2010) Occurrence of maize detritus and a transgenic insecticidal protein (Cry1Ab) within the stream network of an agricultural landscape. Proc Natl Acad Sci USA 107:17645–17650CrossRef
go back to reference Vaeck M, Reynaerts A, Höfte H, Jansens S, De Beuckeleer M, Dean C, Zabeau M, Van Montagu M, Leemans J (1987) Transgenic plants protected from insect attack. Nature 328:33–37CrossRef Vaeck M, Reynaerts A, Höfte H, Jansens S, De Beuckeleer M, Dean C, Zabeau M, Van Montagu M, Leemans J (1987) Transgenic plants protected from insect attack. Nature 328:33–37CrossRef
go back to reference van Frankenhuyzen K (2009) Insecticidal activity of Bacillus thuringiensis crystal proteins. J Invertebr Pathol 101:1–16CrossRef van Frankenhuyzen K (2009) Insecticidal activity of Bacillus thuringiensis crystal proteins. J Invertebr Pathol 101:1–16CrossRef
go back to reference van Rensburg JBJ (2007) First report of field resistance by stem borer, Busseola fusca (Fuller) to Bt-transgenic maize. S Afr J Plant Soil 24:147–151 van Rensburg JBJ (2007) First report of field resistance by stem borer, Busseola fusca (Fuller) to Bt-transgenic maize. S Afr J Plant Soil 24:147–151
go back to reference Van Rie J, McGaughey WH, Johnson DE, Barnett BD, Van Mellaert H (1990) Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis. Science 247:72–74CrossRef Van Rie J, McGaughey WH, Johnson DE, Barnett BD, Van Mellaert H (1990) Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis. Science 247:72–74CrossRef
go back to reference Vaughan H (2003) GM plants and protection against insects—Alternative strategies based on gene technology. Acta Agric Scand B 53:34–40 Vaughan H (2003) GM plants and protection against insects—Alternative strategies based on gene technology. Acta Agric Scand B 53:34–40
go back to reference Viktorov AG (2011) Transfer of Bt corn byproducts from terrestrial to stream ecosystems. Russ J Plant Physiol 58:543–548CrossRef Viktorov AG (2011) Transfer of Bt corn byproducts from terrestrial to stream ecosystems. Russ J Plant Physiol 58:543–548CrossRef
go back to reference Walters FS, Stacy CM, Lee MK, Palekar N, Chen JS (2008) An engineered chymotrypsin/cathepsin G site in domain I renders Bacillus thuringiensis Cry3A active against Western corn rootworm larvae. Appl Environ Microbiol 74:367–374CrossRef Walters FS, Stacy CM, Lee MK, Palekar N, Chen JS (2008) An engineered chymotrypsin/cathepsin G site in domain I renders Bacillus thuringiensis Cry3A active against Western corn rootworm larvae. Appl Environ Microbiol 74:367–374CrossRef
go back to reference Walters FS, de Fontes CM, Hart H, Warren GW, Chen JS (2010) Lepidopteran-active variable-region sequence imparts coleopteran activity in eCry3.1Ab, an engineered Bacillus thuringiensis hybrid insecticidal protein. Appl Environ Microbiol 76:3082–3088CrossRef Walters FS, de Fontes CM, Hart H, Warren GW, Chen JS (2010) Lepidopteran-active variable-region sequence imparts coleopteran activity in eCry3.1Ab, an engineered Bacillus thuringiensis hybrid insecticidal protein. Appl Environ Microbiol 76:3082–3088CrossRef
go back to reference Warren GW, Carozzi NB, Desai N, Koziel MG (1992) Field evaluation of transgenic tobacco containing a Bacillus thuringiensis insecticidal protein gene. J Econ Entomol 85:1651–1659 Warren GW, Carozzi NB, Desai N, Koziel MG (1992) Field evaluation of transgenic tobacco containing a Bacillus thuringiensis insecticidal protein gene. J Econ Entomol 85:1651–1659
go back to reference Whalon ME, Wingerd BA (2003) Bt: mode of action and use. Arch Insect Biochem Physiol 54:200–211CrossRef Whalon ME, Wingerd BA (2003) Bt: mode of action and use. Arch Insect Biochem Physiol 54:200–211CrossRef
go back to reference Wu F (2006) Mycotoxin reduction in Bt corn: potential economic, health, and regulatory impacts. Transgenic Res 15:277–289CrossRef Wu F (2006) Mycotoxin reduction in Bt corn: potential economic, health, and regulatory impacts. Transgenic Res 15:277–289CrossRef
go back to reference Wu ZL, Guo WY, Qiu JZ, Huang TP, Li XB, Guan X (2004) Cloning and localization of vip3A gene of Bacillus thuringiensis. Biotechnol Lett 26:1425–1428CrossRef Wu ZL, Guo WY, Qiu JZ, Huang TP, Li XB, Guan X (2004) Cloning and localization of vip3A gene of Bacillus thuringiensis. Biotechnol Lett 26:1425–1428CrossRef
go back to reference Wu KM, Lu YH, Feng HQ, Jiang YY, Zhao JZ (2008) Suppression of cotton bollworm in multiple crops in China in areas with Bt toxin-containing cotton. Science 321:1676–1678CrossRef Wu KM, Lu YH, Feng HQ, Jiang YY, Zhao JZ (2008) Suppression of cotton bollworm in multiple crops in China in areas with Bt toxin-containing cotton. Science 321:1676–1678CrossRef
go back to reference Xia H, Lu BR, Xu K, Wang W, Yang X, Yang C, Luo J, Lai FX, Ye WL, Fu Q (2011) Enhanced yield performance of Bt rice under target-insect attacks: implications for field insect management. Transgenic Res 20:655–664CrossRef Xia H, Lu BR, Xu K, Wang W, Yang X, Yang C, Luo J, Lai FX, Ye WL, Fu Q (2011) Enhanced yield performance of Bt rice under target-insect attacks: implications for field insect management. Transgenic Res 20:655–664CrossRef
go back to reference Yang Z, Chen H, Tang W, Hua H, Lin Y (2011) Development and characterisation of transgenic rice expressing two Bacillus thuringiensis genes. Pest Manag Sci 67:414–422CrossRef Yang Z, Chen H, Tang W, Hua H, Lin Y (2011) Development and characterisation of transgenic rice expressing two Bacillus thuringiensis genes. Pest Manag Sci 67:414–422CrossRef
go back to reference Zambryski P, Joos H, Genetello C, Leemans J, Montagu MV, Schell J (1983) Ti plasmid vector for the introduction of DNA into plant cells without alteration of their normal regeneration capacity. EMBO J 2:2143–2150 Zambryski P, Joos H, Genetello C, Leemans J, Montagu MV, Schell J (1983) Ti plasmid vector for the introduction of DNA into plant cells without alteration of their normal regeneration capacity. EMBO J 2:2143–2150
go back to reference Zhang H, Yin W, Zhao J, Jin L, Yang Y, Wu S, Tabashnik BE, Wu Y (2011) Early warning of cotton bollworm resistance associated with intensive planting of Bt cotton in China. PLoS One 6:e22874CrossRef Zhang H, Yin W, Zhao J, Jin L, Yang Y, Wu S, Tabashnik BE, Wu Y (2011) Early warning of cotton bollworm resistance associated with intensive planting of Bt cotton in China. PLoS One 6:e22874CrossRef
go back to reference Zhao JZ, Cao J, Li Y, Collins HL, Roush RT, Earle ED, Shelton AM (2003) Transgenic plants expressing two Bacillus thuringiensis toxins delay insect resistance evolution. Nat Biotechnol 21:1493–1497CrossRef Zhao JZ, Cao J, Li Y, Collins HL, Roush RT, Earle ED, Shelton AM (2003) Transgenic plants expressing two Bacillus thuringiensis toxins delay insect resistance evolution. Nat Biotechnol 21:1493–1497CrossRef
go back to reference Zhao JZ, Cao J, Collins HL, Bates SL, Roush RT, Earle ED, Shelton AM (2005) Concurrent use of transgenic plants expressing a single and two Bacillus thuringiensis genes speeds insect adaptation to pyramided plants. Proc Natl Acad Sci USA 102:8426–8430CrossRef Zhao JZ, Cao J, Collins HL, Bates SL, Roush RT, Earle ED, Shelton AM (2005) Concurrent use of transgenic plants expressing a single and two Bacillus thuringiensis genes speeds insect adaptation to pyramided plants. Proc Natl Acad Sci USA 102:8426–8430CrossRef
Metadata
Title
Bt Crops: Past and Future
Authors
Dr. Anais S. Castagnola
Dr. Juan Luis Jurat-Fuentes
Copyright Year
2012
Publisher
Springer Netherlands
DOI
https://doi.org/10.1007/978-94-007-3021-2_15

Premium Partners