Top

Published in:

26-12-2022 | Original Research

Carboxymethyl cellulose-based injectable hydrogel loaded with a composite of melatonin and γ-cyclodextrin with antioxidant property for diabetic wound repair

Authors: Yamei Wang, Dongdong Xiao, Yang Tang, Yezhong Xia, Yi Zhong, Linping Zhang, Xiaofeng Sui, Bijia Wang, Xueling Feng, Hong Xu, Zhiping Mao

Published in: Cellulose | Issue 3/2023

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Overproduction of reactive oxygen species is one of the important reasons of non-healing wounds, such as diabetic wounds. Melatonin is well known as an antioxidant, while the poor solubility limits its use in many areas. In this study, the solubility of melatonin was improved by introducing γ-cyclodextrin to form the composite named MT-γ-CD through ultrasonic process. During this process, the molar ratio of melatonin and γ-cyclodextrin was 2:1, the temperature was set at 30 ℃, and the ultrasonic time was 40 min. The MT-γ-CD showed good antioxidant property in vitro with high free radical scavenging efficiency over 90%. Besides, an injectable self-healing hydrogel was prepared to load with MT-γ-CD to form the wound dressing, here, sodium carboxymethylated cellulose was oxidized to introduce aldehyde groups that could form Schiff base with amino groups in gelatin. This dressing with good biocompatibility could be injected into irregular wounds, suppress the level of reactive oxygen species, and accelerate wound healing of diabetic rats in vivo. Therefore, it has great potential to provide a new treatment strategy for diabetic wounds.

previous article Stable construction of covalent organic framework/copper sulfide heterojunction on cellulose fibers with hyperbranched polyamide-amine for efficient photocatalytic degradation of organic dyes

next article Preparation and characterization of paper-based high barrier material based on heterogeneous graft polymerization

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Available only for authorised users

Armstrong DG, Boulton AJM, Bus SA (2017) Diabetic foot ulcers and their recurrence. N Engl J Med 376:2367–2375. https://doi.org/10.1056/NEJMra1615439CrossRefPubMed

Bucatariu S, Constantin M, Ascenzi P, Fundueanu G (2016) Poly(lactide-co-glycolide)/cyclodextrin (polyethyleneimine) microspheres for controlled delivery of dexamethasone, React Funct Polym 107:46–53. https://doi.org/10.1016/j.reactfunctpolym.2016.08.008

Cao X, Liu H, Yang X, Tian J, Luo B, Liu M (2020) Halloysite nanotubes@polydopamine reinforced polyacrylamide-gelatin hydrogels with NIR light triggered shape memory and self-healing capability. Compos Sci Technol 191:108071. https://doi.org/10.1016/j.compscitech.2020.108071CrossRef

Chen K et al (2021) Injectable melatonin-loaded carboxymethyl chitosan (CMCS)-based hydrogel accelerates wound healing by reducing inflammation and promoting angiogenesis and collagen deposition. J Mater Sci Technol 63:236–245. https://doi.org/10.1016/j.jmst.2020.06.001CrossRef

Chen YL et al (2021) Novel gamma-cyclodextrin-metal-organic frameworks for encapsulation of curcumin with improved loading capacity, physicochemical stability and controlled release properties. Food Chem 347:10. https://doi.org/10.1016/j.foodchem.2020.128978CrossRef

Choi YC, Choi JS, Jung YJ, Cho YW (2014) Human gelatin tissue-adhesive hydrogels prepared by enzyme-mediated biosynthesis of DOPA and Fe³⁺ ion crosslinking. J Mater Chem B 2:201–209. https://doi.org/10.1039/c3tb20696cCrossRefPubMed

Correa VLR, Martins JA, de Souza TR, Rincon GDN, Miguel MP, de Menezes LB, Amaral AC (2020) Melatonin loaded lecithin-chitosan nanoparticles improved the wound healing in diabetic rats. Int J Biol Macromol 162:1465–1475. https://doi.org/10.1016/j.ijbiomac.2020.08.027CrossRef

Cosma AC, Simha R (2018) Thermal comfort modeling in transient conditions using real-time local body temperature extraction with a thermographic camera. Build Sci 143:36–47. https://doi.org/10.1016/j.buildenv.2018.06.052CrossRef

Eivazzadeh-Keihan R, Khalili F, Aliabadi HAM, Maleki A, Madanchi H, Ziabari EZ, Bani MS (2020) Alginate hydrogel-polyvinyl alcohol/silk fibroin/magnesium hydroxide nanorods: a novel scaffold with biological and antibacterial activity and improved mechanical properties. Int J Biol Macromol 162:1959–1971. https://doi.org/10.1016/j.ijbiomac.2020.08.090CrossRefPubMed

Eivazzadeh-Keihan R, Radinekiyan F, Maleki A, Bani MS, Hajizadeh Z, Asgharnasl S (2019) A novel biocompatible core-shell magnetic nanocomposite based on cross-linked chitosan hydrogels for in vitro hyperthermia of cancer therapy. Int J Biol Macromol 140:407–414. https://doi.org/10.1016/j.ijbiomac.2019.08.031CrossRefPubMed

Ferreira EB et al (2018) Characterization and antiproliferative activity of a novel 2-aminothiophene derivative-cyclodextrin binary system. Molecules 23:16. https://doi.org/10.3390/molecules23123130CrossRef

Huang Y et al (2020) Degradable gelatin-based IPN cryogel hemostat for rapidly stopping deep noncompressible hemorrhage and simultaneously improving wound healing. Chem Mater 32:6595–6610. https://doi.org/10.1021/acs.chemmater.0c02030CrossRef

Kant V, Kumari P, Jitendra KD, Ahuja M, Kumar V (2021) Nanomaterials of natural bioactive compounds for wound healing: novel drug delivery approach. Curr Drug Deliv 18:1406–1425. https://doi.org/10.2174/1567201818666210729103712CrossRefPubMed

Khan AUR et al (2021) Multifunctional bioactive core-shell electrospun membrane capable to terminate inflammatory cycle and promote angiogenesis in diabetic wound. Bioact Mater 6:2783–2800. https://doi.org/10.1016/j.bioactmat.2021.01.040CrossRefPubMedPubMedCentral

Kim HS, Sun X, Lee J-H, Kim H-W, Fu X, Leong KW (2019) Advanced drug delivery systems and artificial skin grafts for skin wound healing. Adv Drug Deliv Rev 146:209–239. https://doi.org/10.1016/j.addr.2018.12.014CrossRefPubMed

Li X (2017) 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-Oxide (PTIO•) radical scavenging: a new and simple antioxidant assay in vitro. J Agric Food Chem 65:6288–6297. https://doi.org/10.1021/acs.jafc.7b02247CrossRefPubMed

Liu ZJ, Gan L, Zhang TT, Ren Q, Sun C (2018) Melatonin alleviates adipose inflammation through elevating-ketoglutarate and diverting adipose-derived exosomes to macrophages in mice. J Pineal Res 64:e12455. https://doi.org/10.1111/jpi.12455CrossRef

Luo J-W et al (2019) In situ injectable hyaluronic acid/gelatin hydrogel for hemorrhage control. Mater Sci Eng C-Mater Biol Appl 98:628–634. https://doi.org/10.1016/j.msec.2019.01.034CrossRefPubMed

Maleki A, Eskandarpour V, Rahimi J, Hamidi N (2019) Cellulose matrix embedded copper decorated magnetic bionanocomposite as a green catalyst in the synthesis of dihydropyridines and polyhydroquinolines. Carbohydr Polym 208:251–260. https://doi.org/10.1016/j.carbpol.2018.12.069CrossRefPubMed

Maleki A, Gharibi S, Valadi K, Taheri-Ledari R (2020) Pumice-modified cellulose fiber: An environmentally benign solid state hybrid catalytic system for the synthesis of 2,4,5-triarylimidazole derivatives. J Phys Chem Solids 142:109443. https://doi.org/10.1016/j.jpcs.2020.109443CrossRef

Maleki A, Jafari AA, Yousefi S (2017a) Green cellulose-based nanocomposite catalyst: design and facile performance in aqueous synthesis of pyranopyrimidines and pyrazolopyranopyrimidines. Carbohydr Polym 175:409–416. https://doi.org/10.1016/j.carbpol.2017.08.019CrossRefPubMed

Maleki A, Movahed H, Ravaghi P (2017b) Magnetic cellulose/Ag as a novel eco-friendly nanobiocomposite to catalyze synthesis of chromene-linked nicotinonitriles. Carbohydr Polym 156:259–267. https://doi.org/10.1016/j.carbpol.2016.09.002CrossRefPubMed

Maleki A, Ravaghi P, Aghaei M, Movahed H (2017) A novel magnetically recyclable silver-loaded cellulose-based bionanocomposite catalyst for green synthesis of tetrazolo 1,5-a pyrimidines. Res Chem Intermed 43:5485–5494. https://doi.org/10.1007/s11164-017-2941-4CrossRef

Mirmajidi T, Chogan F, Rezayan AH, Sharifi AM (2021) In vitro and in vivo evaluation of a nanofiber wound dressing loaded with melatonin. Int J Pharm 596:14. https://doi.org/10.1016/j.ijpharm.2021.120213CrossRef

Sen CK (2021) Human wound and its burden: updated 2020 compendium of estimates. Adv Wound Care 10:281–292. https://doi.org/10.1089/wound.2021.0026CrossRef

Shi W et al (2021) Tannic acid-inspired, self-healing, and dual stimuli responsive dynamic hydrogel with potent antibacterial and anti-oxidative properties. J Mater Chem B 9:7182–7195. https://doi.org/10.1039/d1tb00156fCrossRefPubMed

Soni JM, Sardoiwala MN, Choudhury SR, Sharma SS, Karmakar S (2021) Melatonin-loaded chitosan nanoparticles endows nitric oxide synthase 2 mediated anti-inflammatory activity in inflammatory bowel disease model. Mater Sci Eng C-Mater Biol Appl 124:12. https://doi.org/10.1016/j.msec.2021.112038CrossRef

Wan T, Chen DJ (2018) Preparation of beta-cyclodextrin reinforced waterborne polyurethane nanocomposites with excellent mechanical and self-healing property. Compos Sci Technol 168:55–62. https://doi.org/10.1016/j.compscitech.2018.08.049CrossRef

Wang HN, Xu ZJ, Zhao M, Liu GT, Wu J (2021) Advances of hydrogel dressings in diabetic wounds. Biomater Sci 9:1530–1546. https://doi.org/10.1039/d0bm01747gCrossRefPubMed

Wang Y et al (2021) Inflammation-responsive drug-loaded hydrogels with sequential hemostasis, antibacterial, and anti-Inflammatory behavior for chronically infected diabetic wound treatment. ACS Appl Mater Interfaces 13:33584–33599. https://doi.org/10.1021/acsami.1c09889CrossRefPubMed

Wang Y et al (2022a) Mussel-inspired adhesive gelatin-polyacrylamide hydrogel wound dressing loaded with tetracycline hydrochloride to enhance complete skin regeneration. Soft Matter 18:662–674. https://doi.org/10.1039/d1sm01373dCrossRefPubMed

Wang Y et al (2022b) Asymmetric composite wound dressing with hydrophobic flexible bandage and tissue-adhesive hydrogel for joints skin wound healing. Compos Pt B-Eng 235:109762. https://doi.org/10.1016/j.compositesb.2022.109762CrossRef

Winter GD (1995) Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 193:293–294. https://doi.org/10.1038/193293a0CrossRef

Xu D et al (2020) Melatonin protects mouse testes from palmitic acid-induced lipotoxicity by attenuating oxidative stress and DNA damage in a SIRT1-dependent manner. J Pineal Res 69:e12690. https://doi.org/10.1111/jpi.12690CrossRefPubMed

Xuan HY, Ren JY, Wang XZ, Zhang JH, Ge LQ (2017) Flame-retardant, non-irritating and self-healing multilayer films with double-network structure. Compos Sci Technol 145:15–23. https://doi.org/10.1016/j.compscitech.2017.03.038CrossRef

Yang ZF et al (2021) Highly stretchable, adhesive, biocompatible, and antibacterial hydrogel dressings for wound healing. Adv Sci 8:12. https://doi.org/10.1002/advs.202003627CrossRef

Zeng Q, Qi X, Shi G, Zhang M, Haick H (2022) Wound dressing: from nanomaterials to diagnostic dressings and healing evaluations. ACS Nano 16:1708–1733. https://doi.org/10.1021/acsnano.1c08411CrossRefPubMed

Zhang H et al (2021) Multifunctional injectable hydrogel dressings for effectively accelerating wound healing: enhancing biomineralization strategy. Adv Funct Mater 31:2100093. https://doi.org/10.1002/adfm.202100093CrossRef

Zhang M et al (2021) Super-ductile, injectable, fast self-healing collagen-based hydrogels with multi-responsive and accelerated wound-repair properties. Chem Eng J 405:15. https://doi.org/10.1016/j.cej.2020.126756CrossRef

Zhao X, Liang YP, Huang Y, He JH, Han Y, Guo BL (2020) Physical double-network hydrogel adhesives with rapid shape adaptability, fast self-Healing, antioxidant and NIR/pH stimulus-responsiveness for multidrug-resistant bacterial infection and removable wound dressing. Adv Funct Mater 30:1910748. https://doi.org/10.1002/adfm.201910748CrossRef

Zhou L et al (2021) Injectable self-healing natural biopolymer-based hydrogel adhesive with thermoresponsive reversible adhesion for minimally invasive surgery. Adv Funct Mater 31:13. https://doi.org/10.1002/adfm.202007457CrossRef

Zhu S, Yao L, Pan C, Tian J, Lu L (2021) 3D printed gellan gum/graphene oxide scaffold for tumor therapy and bone reconstruction. Compos Sci Technol 208:108763. https://doi.org/10.1016/j.compscitech.2021.108763CrossRef

Zhu SL et al (2022) Engineered multifunctional nanocomposite hydrogel dressing to promote vascularization and anti-inflammation by sustained releasing of Mg²⁺ for diabetic wounds. Compos Pt B-Eng 231:109569. https://doi.org/10.1016/j.compositesb.2021.109569CrossRef

Title: Carboxymethyl cellulose-based injectable hydrogel loaded with a composite of melatonin and γ-cyclodextrin with antioxidant property for diabetic wound repair
Authors: Yamei Wang
Dongdong Xiao
Yang Tang
Yezhong Xia
Yi Zhong
Linping Zhang
Xiaofeng Sui
Bijia Wang
Xueling Feng
Hong Xu
Zhiping Mao
Publication date: 26-12-2022
Publisher: Springer Netherlands
Published in: Cellulose / Issue 3/2023
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-022-04981-0

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Technik"

Springer Professional "Wirtschaft+Technik"

Other articles of this Issue 3/2023

Dye adsorption performance of nanocellulose beads with different carboxyl group content

Efficient separation of cellulose from bamboo by organic alkali

Microstructure, chemical composition and thermal stability of alkali-treated bamboo fibers and parenchyma cells: effects of treatment time and temperature

Valorization of corn cob toward multipurpose fractionation with a recyclable acid hydrotrope: furfural, phenolic compounds, and pulp

One-pot fabrication of bio-based hydrophobic and flame-retardant coating for cotton fabric

Water sorption in wood cell walls–data exploration of the influential physicochemical characteristics