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Population-Based Personalization of Geometric Models of Myocardial Infarction Read chapter Read first chapter

2021 | OriginalPaper | Chapter

Cardiac Support for the Right Ventricle: Effects of Timing on Hemodynamics-Biomechanics Tradeoff

Authors : Ileana Pirozzi, Ali Kight, Edgar Aranda-Michael, Rohan Shad, Yuanjia Zhu, Lewis K. Waldman, William Hiesinger, Mark Cutkosky

Published in: Functional Imaging and Modeling of the Heart

Publisher: Springer International Publishing

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Abstract

A well-established treatment option for advanced heart failure is the implantation of a ventricular assist device (VAD) in the left heart. In over one quarter of patients, however, failure of the right ventricle (RV) occurs shortly after implantation, with a paucity of options for RV failure management in this clinical context. A possible treatment for RV failure is the application of regional mechanical support to the free surface of the RV. Here, we investigate the effect of this treatment using a multiscale finite element model. We discuss a trade-off between hemodynamic benefits and biomechanical effects of simulated interventions with respect to the complex dynamics of RV contraction. Specifically, we report on timing of support with respect to the cardiac cycle, duration of applied force, and force profile distribution. Insights from these preliminary studies can be informative in the rational design of RV-specific mechanical support solutions.

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previous chapter From Clinical Imaging to Patient-Specific Computational Model: Rapid Adaptation of the Living Heart Human Model to a Case of Aortic Stenosis
next chapter In Vivo Pressure-Volume Loops and Chamber Stiffness Estimation Using Real-Time 3D Echocardiography and Left Ventricular Catheterization – Application to Post-heart Transplant Patients
Literature
1.
Argiriou, M., et al.: Right heart failure post left ventricular assist device implantation. J. Thorac. Dis. 6(Suppl. 1), S52 (2014)
2.
Lampert, B.C., Teuteberg, J.J.: Right ventricular failure after left ventricular assist devices. J. Heart Lung Transplant. 34(9), 1123–1130 (2015)CrossRef
3.
Tang, P., et al.: Right ventricular failure following left ventricular assist device implantation is associated with a preoperative pro-inflammatory response. J. Cardiothroac. Surg. 14, 80 (2019)CrossRef
4.
Kapur, N.K., et al.: Mechanical circulatory support devices for acute right ventricular failure. Circulation 136(3), 314–326 (2017)CrossRef
5.
Sidney, S., Go, A.S., Jaffe, M.G., Solomon, M.D., Ambrosy, A.P., Rana, J.S.: Association between aging of the us population and heart disease mortality from 2011 to 2017. JAMA Cardiol. 4(12), 1280–1286 (2019)CrossRef
6.
Horvath, M.A., et al.: An intracardiac soft robotic device for augmentation of blood ejection from the failing right ventricle. Ann. Biomed. Eng. 45(9), 2222–2233 (2017)CrossRef
7.
Aranda-Michel, E., Waldman, L.K., Trumble, D.R.: Left ventricular simulation of cardiac compression: hemodynamics and regional mechanics. PLOS ONE 14(10), e0224475 (2019)
8.
Cokkinos, D.V., Belogianneas, C.: Left ventricular remodelling: a problem in search of solutions. Eur. Cardiol. Rev. 11(1), 29 (2016)CrossRef
9.
Han, J., Kubala, M., Aranda-Michel, E., Trumble, D.R.: Ventricle-specific epicardial pressures as a means to optimize direct cardiac compression for circulatory support: a pilot study. PLOS ONE 14(7), e0219162 (2019)
10.
Guccione, J.M., McCulloch, A.D., Waldman, L.K.: Passive material properties of intact ventricular myocardium determined from a cylindrical model. J. Biomech. Eng. 113(1), 42–55 (1991)CrossRef
11.
Kerckhoffs, R.C.P., Neal, M.L., Gu, Q., Bassingthwaighte, J.B., Omens, J.H., McCulloch, A.D.: Coupling of a 3d finite element model of cardiac ventricular mechanics to lumped systems models of the systemic and pulmonic circulation. Ann. Biomed. Eng. 35(1), 1–18 (2007)CrossRef
12.
Costa, K.D., Hunter, P.J., Wayne, J.S., Waldman, L.K., Guccione, J.M., McCulloch, A.D.: A three-dimensional finite element method for large elastic deformations of ventricular myocardium: II-prolate spheroidal coordinates. J. Biomech. Eng. 118(4), 464–472 (1996)CrossRef
13.
Cevasco, M., et al.: Right heart failure: an ischemic model and restraint therapy for treatment. Ann. Thorac. Surg. 97(4), 1356–1363 (2014)CrossRef
14.
Kerkhof, P.L.M.: Characterizing heart failure in the ventricular volume domain. Clin. Med. Insights Cardiol. 9, 11–31 (2015)
15.
Truong, V.T., et al.: Cardiac magnetic resonance tissue tracking in right ventricle: feasibility and normal values. Magn. Reson. Imaging 38, 189–195 (2017)CrossRef
16.
Mann, D.L., Bristow, M.R.: Mechanisms and models in heart failure: the biomechanical model and beyond. Circulation 111(21), 2837–2849 (2005)CrossRef
17.
Kurrelmeyer, K., et al.: Cardiac remodeling as a consequence and cause of progressive heart failure. Clin. Cardiol. 21(S1), 14–19 (1998)CrossRef
18.
Gripari, P.: Right ventricular dimensions and function: why do we need a more accurate and quantitative imaging? J. Cardiovasc. Echography 25, 19–25 (2015)CrossRef
19.
Lang, R.M., et al.: Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. J. Am. Soc. Echocardiogr. 28, 1–39 (2015)CrossRef
20.
Auger, D.A., Zhong, X., Epstein, F.H., Spottiswoode, B.S.: Mapping right ventricular myocardial mechanics using 3d cine dense cardiovascular magnetic resonance. J. Cardiovasc. Magn. Reson. 14(1), 4 (2012)CrossRef
21.
Fomovsky, G.M., Macadangdang, J.R., Ailawadi, G., Holmes, J.W.: Model-based design of mechanical therapies for myocardial infarction. J. Cardiovasc. Transl. Res. 4(1), 82–91 (2011)CrossRef
Metadata
Title
Cardiac Support for the Right Ventricle: Effects of Timing on Hemodynamics-Biomechanics Tradeoff
Authors
Ileana Pirozzi
Ali Kight
Edgar Aranda-Michael
Rohan Shad
Yuanjia Zhu
Lewis K. Waldman
William Hiesinger
Mark Cutkosky
Copyright Year
2021
Book
Functional Imaging and Modeling of the Heart

Print ISBN: 978-3-030-78709-7

Electronic ISBN: 978-3-030-78710-3

Copyright Year: 2021

DOI
https://doi.org/10.1007/978-3-030-78710-3_37

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