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2021 | OriginalPaper | Buchkapitel

Cardiac Support for the Right Ventricle: Effects of Timing on Hemodynamics-Biomechanics Tradeoff

verfasst von : Ileana Pirozzi, Ali Kight, Edgar Aranda-Michael, Rohan Shad, Yuanjia Zhu, Lewis K. Waldman, William Hiesinger, Mark Cutkosky

Erschienen in: Functional Imaging and Modeling of the Heart

Verlag: Springer International Publishing

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Abstract

A well-established treatment option for advanced heart failure is the implantation of a ventricular assist device (VAD) in the left heart. In over one quarter of patients, however, failure of the right ventricle (RV) occurs shortly after implantation, with a paucity of options for RV failure management in this clinical context. A possible treatment for RV failure is the application of regional mechanical support to the free surface of the RV. Here, we investigate the effect of this treatment using a multiscale finite element model. We discuss a trade-off between hemodynamic benefits and biomechanical effects of simulated interventions with respect to the complex dynamics of RV contraction. Specifically, we report on timing of support with respect to the cardiac cycle, duration of applied force, and force profile distribution. Insights from these preliminary studies can be informative in the rational design of RV-specific mechanical support solutions.

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Vorheriges Kapitel From Clinical Imaging to Patient-Specific Computational Model: Rapid Adaptation of the Living Heart Human Model to a Case of Aortic Stenosis

Nächstes Kapitel In Vivo Pressure-Volume Loops and Chamber Stiffness Estimation Using Real-Time 3D Echocardiography and Left Ventricular Catheterization – Application to Post-heart Transplant Patients

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Titel: Cardiac Support for the Right Ventricle: Effects of Timing on Hemodynamics-Biomechanics Tradeoff
verfasst von: Ileana Pirozzi
Ali Kight
Edgar Aranda-Michael
Rohan Shad
Yuanjia Zhu
Lewis K. Waldman
William Hiesinger
Mark Cutkosky
Verlag: Springer International Publishing
Buch: Functional Imaging and Modeling of the Heart
Print ISBN: 978-3-030-78709-7

Electronic ISBN: 978-3-030-78710-3

Copyright-Jahr: 2021
DOI: https://doi.org/10.1007/978-3-030-78710-3_37

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