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Published in:
1988 | OriginalPaper | Chapter
Current Problems in Quantitative Structure Activity Relationships
Author : Hugo Kubinyi
Published in: Physical Property Prediction in Organic Chemistry
Publisher: Springer Berlin Heidelberg
Included in: Professional Book Archive
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Quantitative structure activity relationships (QSAR) are to be understood as a consequence of the fact that the interactions of drugs with their biological counterparts are determined by intermolecular forces. Thus the structural dependence of biological activities can be described either by physicochemical parameters (Hansch analysis) or by indicator variables encoding different structural features (Free Wilson analysis, pattern recognition).