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Published in:
1987 | OriginalPaper | Chapter
[D-Pro2,D-Trp6,8,Nle10]-Neurokinin B: Pharmacological Profile of a Novel Neurokinin Antagonist
Authors : J. L. Vaught, R. Scott, D. Wright, H. Jacoby
Published in: Substance P and Neurokinins
Publisher: Springer New York
Included in: Professional Book Archive
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Until recently, substance P was the only member of the neurokinin family of peptides of mammalian origin. Thus, sub-classification of neurokinin receptors as well as synthetic efforts to create a neurokinin antagonist utilized substance P as the prototypic peptide [1]. Within the last three years, however, two additional mammalian peptides have been isolated. sequenced, purified and shown to have biological activities characteristic of the neurokinin family: neurokinin A and neurokinin B [2–4].