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2020 | OriginalPaper | Chapter

Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics

Authors : Harleen Kaur, Bandhan Chaterjee, John G. Bruno, Tarun Kumar Sharma

Published in: Aptamers in Biotechnology

Publisher: Springer International Publishing

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Abstract

Defining target product profiles (TPPs) for aptamer-based diagnostics is crucial to the success or failure of aptamer businesses or products. A well-conceived TPP will place the aptamer in an assay for a target against which antibodies are ill-suited or have difficulty detecting the analyte, such as some highly related proteins or poorly immunogenic small molecule haptens. Strong TPPs can also take advantage of the unique nucleic acid nature of aptamers, to produce assays with longer shelf life or special chemical properties and ability to be modified versus protein-based antibodies. The following chapter reviews the essence of well-conceived TPPs especially with respect to aptamer targets for diagnostics and illustrates several examples of commercial aptamer diagnostic success.

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previous chapter Aptamer-Modified Nanoparticles in Medical Applications

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Title: Defining Target Product Profiles (TPPs) for Aptamer-Based Diagnostics
Authors: Harleen Kaur
Bandhan Chaterjee
John G. Bruno
Tarun Kumar Sharma
Publisher: Springer International Publishing
Book: Aptamers in Biotechnology
Print ISBN: 978-3-030-54060-9

Electronic ISBN: 978-3-030-54061-6

Copyright Year: 2020
DOI: https://doi.org/10.1007/10_2019_104

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