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Journal of Materials Science

Published in:

01-10-2014

Development of cytocompatible antibacterial electro-spun nanofibrous composites

Authors: Qianyuan Jiang, Zhiming Jiang, Kaikai Ma, Rong Li, Jinmei Du, Zhiwei Xie, Xuehong Ren, T. S. Huang

Published in: Journal of Materials Science | Issue 19/2014

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Abstract

This study presents a method of producing biocompatible nanofibrous composites containing antimicrobial polymers which have excellent antimicrobial efficacy. Specifically, antimicrobial cellulose acetate (CA) nanofibrous composites were prepared by adding poly[5,5-dimethyl-3-(3′-triethoxysilylpropyl)hydantoin] (PBA) to the CA solution using the electro-spinning technique followed with curing and exposure to diluted sodium hypochlorite. Scanning electron microscopy images demonstrated that CA nanofibers formed with diameters of 172 ± 62 nm. The chlorinated CA nanofibrous mats showed good UVA stability. The chlorinated CA nanofibrous mats completely inactivated Staphylococcus aureus (gram-positive) and Escherichia coli O157:H7 (gram-negative) within 30 min of contact time. The cell culture assay showed that the N-halamine-modified CA nanofibrous composites are non-toxic in vitro.

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Title: Development of cytocompatible antibacterial electro-spun nanofibrous composites
Authors: Qianyuan Jiang
Zhiming Jiang
Kaikai Ma
Rong Li
Jinmei Du
Zhiwei Xie
Xuehong Ren
T. S. Huang
Publication date: 01-10-2014
Publisher: Springer US
Published in: Journal of Materials Science / Issue 19/2014
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI: https://doi.org/10.1007/s10853-014-8285-1

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