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09-10-2022 | Original Paper

Effect of amphiphilic phosphorous dendrons on the conformation, secondary structure, and zeta potential of albumin and thrombin

Authors: Maria Terehova, Jakub Magiera, Jieru Qiu, Jean-Pierre Majoral, Xiangyang Shi, Serge Mignani, Maksim Ionov, Iveta Waczulikova, Maria Bryszewska, Dzmitry Shcharbin

Published in: Polymer Bulletin | Issue 8/2023

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Abstract

Amphiphilic dendrons are highly branched synthetic polymeric soft nanoparticles that possess properties of both dendrimers and micelles. Such properties allow dendrons to become promising delivery systems for targeted delivery. While much attention is focused on the design and biological effect of a drug-delivery system, the nature of its interaction with surrounding tissues—their biocompatibility—is crucial for further optimization. The biocompatibility and biological effects of some amphiphilic phosphorus dendrons on human serum albumin and thrombin are investigated in this report. The results from protein fluorescence, circular dichroism, and zeta potential experiments showed that the dendrons of the first generation have a lesser impact on protein molecules than the dendrons of the second generation and therefore tend to be more biocompatible.

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Title: Effect of amphiphilic phosphorous dendrons on the conformation, secondary structure, and zeta potential of albumin and thrombin
Authors: Maria Terehova
Jakub Magiera
Jieru Qiu
Jean-Pierre Majoral
Xiangyang Shi
Serge Mignani
Maksim Ionov
Iveta Waczulikova
Maria Bryszewska
Dzmitry Shcharbin
Publication date: 09-10-2022
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 8/2023
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-022-04512-8

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