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09.10.2022 | Original Paper

Effect of amphiphilic phosphorous dendrons on the conformation, secondary structure, and zeta potential of albumin and thrombin

verfasst von: Maria Terehova, Jakub Magiera, Jieru Qiu, Jean-Pierre Majoral, Xiangyang Shi, Serge Mignani, Maksim Ionov, Iveta Waczulikova, Maria Bryszewska, Dzmitry Shcharbin

Erschienen in: Polymer Bulletin | Ausgabe 8/2023

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Abstract

Amphiphilic dendrons are highly branched synthetic polymeric soft nanoparticles that possess properties of both dendrimers and micelles. Such properties allow dendrons to become promising delivery systems for targeted delivery. While much attention is focused on the design and biological effect of a drug-delivery system, the nature of its interaction with surrounding tissues—their biocompatibility—is crucial for further optimization. The biocompatibility and biological effects of some amphiphilic phosphorus dendrons on human serum albumin and thrombin are investigated in this report. The results from protein fluorescence, circular dichroism, and zeta potential experiments showed that the dendrons of the first generation have a lesser impact on protein molecules than the dendrons of the second generation and therefore tend to be more biocompatible.

Vorheriger Artikel Synthesis and characterization of polyimides from diisocyanate with enhanced solubility and thermostability properties via direct low-temperature one-step polymerization in NMP solvent

Nächster Artikel Gamma irradiation boosted the optical and electrical properties of PVP/NaAlg/Au ternary nanocomposite films for flexible optoelectronic devices

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Titel: Effect of amphiphilic phosphorous dendrons on the conformation, secondary structure, and zeta potential of albumin and thrombin
verfasst von: Maria Terehova
Jakub Magiera
Jieru Qiu
Jean-Pierre Majoral
Xiangyang Shi
Serge Mignani
Maksim Ionov
Iveta Waczulikova
Maria Bryszewska
Dzmitry Shcharbin
Publikationsdatum: 09.10.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Polymer Bulletin / Ausgabe 8/2023
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-022-04512-8

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