Skip to main content
Fachgebiete
Automobil + Motoren Bauwesen + Immobilien Business IT + Informatik Elektrotechnik + Elektronik Energie + Nachhaltigkeit Finance + Banking Management + Führung Marketing + Vertrieb Maschinenbau + Werkstoffe Versicherung + Risiko
DE
EN
Themenseiten
Organisationspsychologie Projektmanagement Marketing Smart Manufacturing
Bücher
Zeitschriften
Weitere Formate
Podcasts Webinare Technik Webinare Wirtschaft Kongresse Veranstaltungskalender Awards
Jetzt Einzelzugang starten
Zugang für Unternehmen
Referenzkunden
MTZ-Fachkongress

Antriebe und Energiesysteme von morgen


Austausch von Automobil- und Energiewirtschaft

Am 14./15. Mai geht es in Chemnitz um die Mobilitätswende durch Elektro- und Wasserstofffahrzeuge.
Erweiterte Suche
Anmelden
nach oben
Polymer Bulletin
Erschienen in: Polymer Bulletin 8/2023

26.09.2022 | Original Paper

Nanofibrous chitosan/polyethylene oxide silver/hydroxyapatite/silica composite as a potential biomaterial for local treatment of periodontal disease

verfasst von: Fatemeh Hakimi, Samaneh Hashemikia, Somayeh Sadighian, Ali Ramazani

Erschienen in: Polymer Bulletin | Ausgabe 8/2023

Einloggen

Aktivieren Sie unsere intelligente Suche, um passende Fachinhalte oder Patente zu finden.

search-config
loading …

Abstract

Periodontal disease is a set of inflammatory conditions affecting the tissues surrounding the teeth, which can be fairly preventable. In this research, antibacterial polymeric nanofibers were prepared for the management of periodontal disease treatment. New hybrid organic/inorganic nanofibers of chitosan/polyethylene oxide (CS/PEO) contains doxycycline hyclate (DOXH) (as an antibacterial drug) and silver/hydroxyapatite/silica (Ag/HA/Si) nanocomposite (CS/PEO-DOXH-Ag/HA/Si) fabricated by electrospinning technique. The nanofibers were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), field emission scanning electron microscope (FE-SEM), thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). In vitro release profile, degradation (DE) test, swelling (SW) test, antimicrobial activity and cell viability were also obtained. The DOXH release profile was measured by ultraviolet visible (UV–Vis) spectrophotometer in artificial saliva (pH 6.8) at 37 °C. The application of Ag/HA/Si increased the morphological integrity during the degradation process and decreased the rate of drug delivery. The electrospun nanofibers showed an enhanced antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Streptococcus mutans (S. mutans) bacterium strains with the lowest DOXH amount, which can reduce the high dosage of antibiotics and side effects. Cell viability assays revealed that the prepared nanofibers had no cytotoxicity against the human gingival fibroblast 2 (HGF-2) cell line. The results suggest that the prepared organic/inorganic hybrid nanofibers with drug delivery properties could be a promising candidate for the treatment of periodontal diseases.
Vorheriger Artikel Effects of strain rate and temperature on the mechanical behavior of polymethyl methacrylate (PMMA)
Nächster Artikel Rheological properties and ultra-high salt resistance of novel hydrophobically associating copolymers for fracturing fluids

Sie haben noch keine Lizenz? Dann Informieren Sie sich jetzt über unsere Produkte:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

  • über 102.000 Bücher
  • über 537 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Finance + Banking
  • Management + Führung
  • Marketing + Vertrieb
  • Maschinenbau + Werkstoffe
  • Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

Jetzt informieren

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

  • über 67.000 Bücher
  • über 390 Zeitschriften

aus folgenden Fachgebieten:

  • Automobil + Motoren
  • Bauwesen + Immobilien
  • Business IT + Informatik
  • Elektrotechnik + Elektronik
  • Energie + Nachhaltigkeit
  • Maschinenbau + Werkstoffe




 

Jetzt Wissensvorsprung sichern!

Jetzt informieren
Literatur
1.
Wong LB, Yap AU, Allen PF (2021) Periodontal disease and quality of life: umbrella review of systematic reviews. J Periodontal Res 56:1–17PubMed
2.
Janakiram C (2000) Dye BA (2020) A public health approach for prevention of periodontal disease. Periodontol 84:202–214
3.
Johnson A, Kong F, Miao S, Lin H-TV, Thomas S, Huang Y-C et al (2020) Therapeutic effects of antibiotics loaded cellulose nanofiber and κ-carrageenan oligosaccharide composite hydrogels for periodontitis treatment. Sci Rep 10:1–23
4.
Balejo RDP, Cortelli JR, Costa FO, Cyrino RM, Aquino DR, Cogo-Müller K et al (2017) Effects of chlorhexidine preprocedural rinse on bacteremia in periodontal patients: a randomized clinical trial. J Appl Oral Sci 25:586–595PubMedPubMedCentral
5.
Pejčić A, Kesić L, Obradović R, Mirković D (2010) Antibiotics in the management of periodontal disease. Acta Fac med Naiss 27.
6.
Jepsen K, Jepsen S (2016) Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis. J Periodontol 71:82–112
7.
Dias AM, da Silva FG, de Figueiredo Monteiro AP, Pinzón-García AD, Sinisterra RD, Cortés ME (2019) Polycaprolactone nanofibers loaded oxytetracycline hydrochloride and zinc oxide for treatment of periodontal disease. Mater Sci Eng C 103:109798
8.
Steinberg D, Friedman M (2020) Sustained-release delivery of antimicrobial drugs for the treatment of periodontal diseases: fantasy or already reality? J Periodontol 84:176–187
9.
Nguyen S, Hiorth M (2015) Advanced drug delivery systems for local treatment of the oral cavity. Ther Deliv 6:595–608PubMed
10.
Chadha VS, Bhat KM (2012) The evaluation of doxycycline controlled release gel versus doxycycline controlled release implant in the management of periodontitis. J Indian Soc Periodontol 16:200PubMedPubMedCentral
11.
Bapat RA, Joshi CP, Bapat P, Chaubal TV, Pandurangappa R, Jnanendrappa N et al (2019) The use of nanoparticles as biomaterials in dentistry. Drug Discov 24:85–98
12.
Zięba M, Chaber P, Duale K, Martinka Maksymiak M, Basczok M, Kowalczuk M et al (2020) Polymeric carriers for delivery systems in the treatment of chronic periodontal disease. Polymers 12:1574PubMedPubMedCentral
13.
Eskitoros-Togay ŞM, Bulbul YE, Tort S, Korkmaz FD, Acartürk F, Dilsiz N (2019) Fabrication of doxycycline-loaded electrospun PCL/PEO membranes for a potential drug delivery system. Int J Pharm 565:83–94PubMed
14.
Fakhri E, Eslami H, Maroufi P, Pakdel F, Taghizadeh S, Ganbarov K et al (2020) Chitosan biomaterials application in dentistry. Int J Biol Macromol 162:956–974PubMed
15.
Divakar DD, Jastaniyah NT, Altamimi HG, Alnakhli YO, Alkheraif AA, Haleem S (2018) Enhanced antimicrobial activity of naturally derived bioactive molecule chitosan conjugated silver nanoparticle against dental implant pathogens. Int J Biol Macromol 108:790–797PubMed
16.
Tao F, Cheng Y, Shi X, Zheng H, Du Y, Xiang W et al (2020) Applications of chitin and chitosan nanofibers in bone regenerative engineering. Carbohydr Polym 230:115658PubMed
17.
Abid S, Hussain T, Nazir A, Zahir A, Ramakrishna S, Hameed M et al (2019) Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management. Int J Biol Macromol 135:1222–1236PubMed
18.
Husain S, Al-Samadani KH, Najeeb S, Zafar MS, Khurshid Z, Zohaib S et al (2017) Chitosan biomaterials for current and potential dental applications. Materials 10:602PubMedPubMedCentral
19.
Yuan TT, Jenkins PM, DiGeorge Foushee AM, Jockheck-Clark AR, Stahl JM (2016) Electrospun chitosan/polyethylene oxide nanofibrous scaffolds with potential antibacterial wound dressing applications. J Nanomater 2016:1–10
20.
Aliabadi M, Irani M, Ismaeili J, Piri H, Parnian MJ (2013) Electrospun nanofiber membrane of PEO/Chitosan for the adsorption of nickel, cadmium, lead and copper ions from aqueous solution. Chem Eng J 220:237–243
21.
Chen C-K, Liao M-G, Wu Y-L, Fang Z-Y, Chen J-A (2020) Preparation of highly swelling/antibacterial cross-linked N-maleoyl-functional chitosan/polyethylene oxide nanofiber meshes for controlled antibiotic release. Mol Pharm 17:3461–3476PubMed
22.
Chaturvedi TP, Srivastava R, Srivastava AK, Gupta V, Verma PK (2012) Evaluation of metronidazole nanofibers in patients with chronic periodontitis: a clinical study. Int J Pharm Investig 2:213PubMedPubMedCentral
23.
Chaturvedi T, Srivastava R, Srivastava A, Gupta V, Verma PK (2013) Doxycycline poly e-caprolactone nanofibers in patients with chronic periodontitis—a clinical evaluation. J Clin Diagn Res 7:2339PubMedPubMedCentral
24.
Carvalho LDd, Peres BU, Maezono H, Shen Y, Haapasalo M, Jackson J et al (2019) Doxycycline release and antibacterial activity from PMMA/PEO electrospun fiber mats. J Appl Oral Sci 27.
25.
Khampieng T, Wnek GE, Supaphol PJJoBS, Polymer Edition (2014) Electrospun DOXY-h loaded-poly (acrylic acid) nanofiber mats: in vitro drug release and antibacterial properties investigation. J Biomater Sci Polym Ed 25:1292–1305PubMed
26.
Bhushan J, Maini C (2019) Nanoparticles: a promising novel adjunct for dentistry. Indian J Dent Sci 11:167
27.
Ebrahimi Z, Arezumand R, Ramazani A (2018) Nanobody as a new generation of functional proteins. Iran J Pharmaceutical Sci 14:91–106
28.
Bapat RA, Chaubal TV, Joshi CP, Bapat PR, Choudhury H, Pandey M et al (2018) An overview of application of silver nanoparticles for biomaterials in dentistry. J Mater Sci 91:881–898
29.
Zupančič Š, Casula L, Rijavec T, Lapanje A, Luštrik M, Fadda AM et al (2019) Sustained release of antimicrobials from double-layer nanofiber mats for local treatment of periodontal disease, evaluated using a new micro flow-through apparatus. J Control Release 316:223–235PubMed
30.
Khan G, Yadav SK, Patel RR, Kumar N, Bansal M, Mishra B (2017) Tinidazole functionalized homogeneous electrospun chitosan/poly (ε-caprolactone) hybrid nanofiber membrane: development, optimization and its clinical implications. Int J Biol Macromol 103:1311–1326PubMed
31.
Zupančič Š, Preem L, Kristl J, Putrinš M, Tenson T, Kocbek P et al (2018) Impact of PCL nanofiber mat structural properties on hydrophilic drug release and antibacterial activity on periodontal pathogens. Eur J Pharm Sci 122:347–358PubMed
32.
Monteiro AP, Rocha CM, Oliveira MF, Gontijo SM, Agudelo RR, Sinisterra RD et al (2017) Nanofibers containing tetracycline/β-cyclodextrin: Physico-chemical characterization and antimicrobial evaluation. Carbohydr Polym 156:417–426PubMed
33.
Kopytynska-Kasperczyk A, Dobrzynski P, Pastusiak M, Jarzabek B, Prochwicz W (2015) Local delivery system of doxycycline hyclate based on ϵ-caprolactone copolymers for periodontitis treatment. Int J Pharm 491:335–344PubMed
34.
Ciobanu CS, Massuyeau F, Constantin LV, Predoi D (2011) Structural and physical properties of antibacterial Ag-doped nano-hydroxyapatite synthesized at 100 C. Nanoscale Res Lett 6:1–8.
35.
Hao X, Hu X, Zhang C, Chen S, Li Z, Yang X et al (2015) Hybrid mesoporous silica-based drug carrier nanostructures with improved degradability by hydroxyapatite. ACS Nano 9:9614–9625PubMed
36.
Zhuang Y, Yu H, Lin K (2019) Advance of nano-composite electrospun fibers in periodontal regeneration. Front Chem 7:495PubMedPubMedCentral
37.
Yassin FM, Fathy MM, Fahmy HM, Elshemey WM (2021) Low-angle X-ray scattering for the determination of the size of mesoporous silica nanoparticles. Radiat Phys Chem 179:109235
38.
Kermanian M, Sadighian S, Ramazani A, Naghibi M, Hosseini SHJC (2021) A novel mesoporous superparamagnetic hybrid silica/hydroxyapatite nanocomposite as MRI contrast agent. ChemNanoMat 7:284–291
39.
Qasim SB, Najeeb S, Delaine-Smith RM, Rawlinson A, Rehman IU (2017) Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration. Dent Mater J 33:71–83
40.
Scholz M, Reske T, Böhmer F, Hornung A, Grabow N, Lang H (2017) In vitro chlorhexidine release from alginate based microbeads for periodontal therapy. PLoS ONE 12:e0185562PubMedPubMedCentral
41.
Bajpai S, Jadaun M, Bajpai M, Jyotishi P, Shah FF, Tiwari SJ (2017) Controlled release of Doxycycline from gum acacia/poly (sodium acrylate) microparticles for oral drug delivery. Int J Biol Macromol 104:1064–1071PubMed
42.
Praveen N, Rajesh A, Madan M, Chaurasia VR, Hiremath NV, Sharma AM (2014) In vitro evaluation of antibacterial efficacy of pineapple extract (bromelain) on periodontal pathogens. J Int Oral Health 6:96PubMedPubMedCentral
43.
Holešová S, Hundáková M, Tarasiuk Y, Barabaszová KČ, Pazdziora E (2021) Metronidazole/clay nanocomposites: synthesis, structure and antibacterial efficacy. Mater Today 37:1–27
44.
45.
Feura ES, Yang L, Schoenfisch MH (2021) Antibacterial activity of nitric oxide-releasing carboxymethylcellulose against periodontal pathogens. J Biomed Mater Res A 109:713–721PubMed
46.
Amiri N, Ajami S, Shahroodi A, Jannatabadi N, Darban SA, Bazzaz BSF et al (2020) Teicoplanin-loaded chitosan-PEO nanofibers for local antibiotic delivery and wound healing. Int J Biol Macromol 162:645–656PubMed
47.
Ramalingam R, Dhand C, Leung CM, Ong ST, Annamalai SK, Kamruddin M et al (2019) Antimicrobial properties and biocompatibility of electrospun poly-ε-caprolactone fibrous mats containing Gymnema sylvestre leaf extract. J Mater Sci 98:503–514
48.
Su F, Wang Y, Liu X, Shen X, Zhang X, Xing Q et al (2018) Biocompatibility and in vivo degradation of chitosan based hydrogels as potential drug carrier. J Biomater Sci Polym Ed 29:1515–1528PubMed
49.
Ni Z, Gu X, He Y, Wang Z, Zou X, Zhao Y et al (2018) Synthesis of silver nanoparticle-decorated hydroxyapatite (HA@ Ag) poriferous nanocomposites and the study of their antibacterial activities. RSC Adv 8:41722–41730.
50.
Zamperini C, André R, Longo V, Mima E, Vergani CE, Machado AL et al (2013) Antifungal applications of Ag-decorated hydroxyapatite nanoparticles. J Nanomater. 2013:1–9
51.
Kim S-G, Hagura N, Iskandar F, Okuyama K (2009) Characterization of silica-coated Ag nanoparticles synthesized using a water-soluble nanoparticle micelle. Adv Powder Technol 20:94–100
52.
Yamada S, Nishikawa M, Tagaya M (2018) Mesoporous silica formation on hydroxyapatite nanoparticles. Mater Lett 211:220–224
53.
Gorrasi G, Longo R, Viscusi G (2020) Fabrication and characterization of electrospun membranes based on “Poly (ε-caprolactone)”, “Poly (3-hydroxybutyrate)” and their blend for tunable drug delivery of curcumin. Polymers 12:2239PubMedPubMedCentral
54.
Naseri N, Algan C, Jacobs V, John M, Oksman K, Mathew AP (2014) Electrospun chitosan-based nanocomposite mats reinforced with chitin nanocrystals for wound dressing. Carbohydr Polym 109:7–15PubMed
55.
Chen G, Fang D, Wang K, Nie J, Ma G (2015) Core–shell structure PEO/CS nanofibers based on electric field induced phase separation via electrospinning and its application. J Polym Sci, Part A-1: Polym Chem 53:2298–2311.
56.
Mallakpour S, Abbasi M (2020) Hydroxyapatite mineralization on chitosan-tragacanth gum/silica@ silver nanocomposites and their antibacterial activity evaluation. Int J Biol Macromol 151:909–923PubMed
57.
Sadighian S, Rostamizadeh K, Hosseini M-J, Hamidi M, Hosseini-Monfared H (2017) Magnetic nanogels as dual triggered anticancer drug delivery: toxicity evaluation on isolated rat liver mitochondria. Toxicol Lett 278:18–29PubMed
58.
Stie MB, Gätke JR, Wan F, Chronakis IS, Jacobsen J, Nielsen HM (2020) Swelling of mucoadhesive electrospun chitosan/polyethylene oxide nanofibers facilitates adhesion to the sublingual mucosa. Carbohydr Polym 242:116428PubMed
59.
Shahryari F, Rabiei Z, Sadighian S (2020) Antibacterial activity of synthesized silver nanoparticles by sumac aqueous extract and silver-chitosan nanocomposite against Pseudomonas syringae pv. syringae. J Plant Pathol 102:469–475
60.
Kumar S, Koh J (2012) Physiochemical, optical and biological activity of chitosan-chromone derivative for biomedical applications. Int J Mol Sci 13:6102–6116PubMedPubMedCentral
61.
Hashemikia S, Farhangpazhouh F, Parsa M, Hasan M, Hassanzadeh A, Hamidi M (2021) Fabrication of ciprofloxacin-loaded chitosan/polyethylene oxide/silica nanofibers for wound dressing application: In vitro and in vivo evaluations. Int J Pharm, 120313.
62.
Ramya R, Sudha P, Mahalakshmi J (2012) Preparation and characterization of chitosan binary blend. Int J Sci Res Publ 2:1–9
63.
An J, Zhang H, Zhang J, Zhao Y, Yuan XJC, Science P (2009) Preparation and antibacterial activity of electrospun chitosan/poly (ethylene oxide) membranes containing silver nanoparticles. Colloid Polymer Sci 287:1425–1434.
64.
Kohsari I, Shariatinia Z, Pourmortazavi SMJCp (2016) Antibacterial electrospun chitosan–polyethylene oxide nanocomposite mats containing bioactive silver nanoparticles. Int J Biol Macromol 140:287–298.
65.
Qasim SB, Najeeb S, Delaine-Smith RM, Rawlinson A, Rehman IU (2017) Potential of electrospun chitosan fibers as a surface layer in functionally graded GTR membrane for periodontal regeneration. Dent Mater 33:71–83PubMed
66.
Abid S, Hussain T, Nazir A, Zahir A, Ramakrishna S, Hameed M et al (2019) Enhanced antibacterial activity of PEO-chitosan nanofibers with potential application in burn infection management. Int J Biol Macrool 135:1222–1236
67.
Hashemikia S, Farhangpazhouh F, Parsa M, Hasan M, Hassanzadeh A, Hamidi M (2021) Fabrication of ciprofloxacin-loaded chitosan/polyethylene oxide/silica nanofibers for wound dressing application: in vitro and in vivo evaluations. Int J Pharm 597:120313PubMed
68.
Kouhi M, Morshed M, Varshosaz J, Fathi MH (2013) Poly (ε-caprolactone) incorporated bioactive glass nanoparticles and simvastatin nanocomposite nanofibers: preparation, characterization and in vitro drug release for bone regeneration applications. Chem Eng J 228:1057–1065
69.
Wu J, Zhang Z, Zhou W, Liang X, Zhou G, Han CC et al (2020) Mechanism of a long-term controlled drug release system based on simple blended electrospun fibers. J Control Release 320:337–346PubMed
70.
Kataria K, Gupta A, Rath G, Mathur R, Dhakate S (2014) In vivo wound healing performance of drug loaded electrospun composite nanofibers transdermal patch. Int J Pharm 469:102–110PubMed
71.
Goudouri O-M, Kontonasaki E, Lohbauer U, Boccaccini AR (2014) Antibacterial properties of metal and metalloid ions in chronic periodontitis and peri-implantitis therapy. Acta Biomater 10:3795–3810PubMed
Metadaten
Titel
Nanofibrous chitosan/polyethylene oxide silver/hydroxyapatite/silica composite as a potential biomaterial for local treatment of periodontal disease
verfasst von
Fatemeh Hakimi
Samaneh Hashemikia
Somayeh Sadighian
Ali Ramazani
Publikationsdatum
26.09.2022
Verlag
Springer Berlin Heidelberg
Erschienen in
Polymer Bulletin / Ausgabe 8/2023
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-022-04466-x

Weitere Artikel der Ausgabe 8/2023

Polymer Bulletin 8/2023 Zur Ausgabe

Original Paper

The effect of thermal setting, solvent type, and concentration on the tensile behavior of electrospun PLGA and polyamide nanofiber yarns simulated with the modified viscoelastic model

Original Paper

Study of the incorporation of oleoresin Capsicum as an interfacial agent in starch-poly(lactic acid) bilayer films

Original Paper

Flame retardant coating of textile fabrics based on ionic liquids with self-extinguishing, high thermal stability and mechanical properties

Original Paper

Hydrogel bio-nanocomposite beads based on alginate and silica: physicochemical and in vitro bioactivity evaluations

Original Paper

Effects of strain rate and temperature on the mechanical behavior of polymethyl methacrylate (PMMA)

Original Paper

Elaboration and characterization of new adsorbents based on conducting PANI/zeolite HY/TiO2 nanocomposite applied for chromate adsorption

Premium Partner

    Marktübersichten

    Die im Laufe eines Jahres in der „adhäsion“ veröffentlichten Marktübersichten helfen Anwendern verschiedenster Branchen, sich einen gezielten Überblick über Lieferantenangebote zu verschaffen. 

    Zur Marktübersicht
    Bildnachweise