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Polymer Bulletin

Erschienen in:

06.10.2022 | Original Paper

Hydrogel bio-nanocomposite beads based on alginate and silica: physicochemical and in vitro bioactivity evaluations

verfasst von: Shadpour Mallakpour, Fatemeh-Sadat Sadeghi-Kaji

Erschienen in: Polymer Bulletin | Ausgabe 8/2023

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Abstract

Tissue engineering seeks to emulation of the tissue's biological properties. In the domain of bone repair, tissue engineering is looking for bioactive alternatives. The current work aims to prepare calcium alginate/SiO₂bio-nanocomposite (bio-NC) beads with the bioactivity inherent feature for use in bone tissue engineering. In this way, at first, different amounts of SiO₂ nanoparticles (NPs) (4, 8, and 12 wt.%) were homogeneously dispersed into the sodium alginate solution using ultrasound waves. Then, spherical NC beads were produced by dropping sodium alginate/SiO₂bio-NC into the CaCl₂solution as a cross-linking agent until the reaction was complete. Transmission electron microscopy micrographs revealed homogeneous dispersion of SiO₂NPs into the calcium alginate. Finally, the bioactivity properties of calcium alginate/SiO₂bio-NC beads were confirmed through energy dispersive X-ray spectroscopy with the formation of hydroxyapatite layers after immersing them in the simulated body fluid solution.

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Titel: Hydrogel bio-nanocomposite beads based on alginate and silica: physicochemical and in vitro bioactivity evaluations
verfasst von: Shadpour Mallakpour
Fatemeh-Sadat Sadeghi-Kaji
Publikationsdatum: 06.10.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Polymer Bulletin / Ausgabe 8/2023
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-022-04506-6

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