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30.09.2022 | Original Paper

Preparation and release behavior of poly(methyl methacrylate-co-methacrylic acid)-based electrospun nanofibrous mats loaded with doxorubicin

verfasst von: Roberto López-Muñoz, Raúl Guillermo López, Hened Saade, Angel Licea-Claverie, Francisco Javier Enríquez-Medrano, Graciela Morales, Daniel Grande

Erschienen in: Polymer Bulletin | Ausgabe 8/2023

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Abstract

A drug-loaded electrospun mat is a potential fibrous material for cancer treatment after a surgery procedure. In this study, the methacrylic copolymer poly(methyl methacrylate-co-methacrylic acid) [P(MMA-co-MAA)] was synthesized by semi-continuous heterophase polymerization as a nanofiber carrier to load an anticancer drug, doxorubicin hydrochloride (DOX). Eudragit® S100 (ES100) nanofibers loaded with DOX were also prepared for comparison. The electrospun nanofibers were loaded at different DOX concentrations, where the homogeneous fiber morphology did not change with the drug-loaded increase. The confocal microscopic images indicated that the drug was incorporated to a major extent into the synthesized copolymer than the ES100 nanofibers, through electrostatic interactions or hydrogen bonding. The In-vitro release profiles of DOX presented a lower release rate for the synthesized copolymer around 12% after 72 h, compared to 44% released from ES100 copolymer. Both copolymers presented a two-stage diffusion-controlled mechanism, which obeyed Fick's second law. Based on these results, the synthesized methacrylic copolymer exhibited a high potential to release the drug in a sustained and prolonged manner. Thus, P(MMA-co-MAA) DOX-loaded electrospun mats have the potential to be used as local implantable fibrous material for postsurgical cancer treatment.

Vorheriger Artikel Synthesis and characterization of functionalized modified PVC-chitosan as antimicrobial polymeric biomaterial

Nächster Artikel Influence of hydrophobic association in the aqueous media on the rheology and polymer conformation of associative polymers

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Titel: Preparation and release behavior of poly(methyl methacrylate-co-methacrylic acid)-based electrospun nanofibrous mats loaded with doxorubicin
verfasst von: Roberto López-Muñoz
Raúl Guillermo López
Hened Saade
Angel Licea-Claverie
Francisco Javier Enríquez-Medrano
Graciela Morales
Daniel Grande
Publikationsdatum: 30.09.2022
Verlag: Springer Berlin Heidelberg
Erschienen in: Polymer Bulletin / Ausgabe 8/2023
Print ISSN: 0170-0839
Elektronische ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-022-04481-y

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