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Polymer Bulletin

07-04-2024 | ORIGINAL PAPER

Erlotinib-entrapped gellan gum/carboxymethyl fenugreek seed mucilage-based thermo/pH-sensitive matrices

Authors: Yasir Faraz Abbasi, Hriday Bera, Abhimanyu Thakur

Published in: Polymer Bulletin

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Abstract

Carboxymethyl fenugreek seed mucilage-grafted poly-N-isopropylacrylamide/montmorillonite [CFSM-g-PNIPA/MMT] nanocomposites (NCs) were dually crosslinked with gellan gum (GG) to afford interpenetrating polymer network (IPN) matrices for effective delivery of erlotinib HCl (ERL) to the triple-negative breast cancer (TNBC) cells. The IPN matrices with different reinforcing clay (MMT) contents (0–20%) demonstrated comparable size (1.64–1.80 mm) and acceptable drug loading capacity (DEE, 47.97–89.35%). The infrared, thermal and X-ray analyses implied the compatibility between drug and matrix constituents, and the SEM studies conferred the spherical morphology of the IPN matrices. Moreover, these hydrogel matrices portrayed temperature-responsive swelling profiles and their molar masses between crosslinks \(\left( {\bar{M}_{{\text{c}}} } \right)\) were increased with temperature. Among different matrices, the composites containing 20% MMT (F-3) revealed the sustained drug release profiles, which were best fitted to the Higuchi model with an anomalous transport-driven mechanism. These matrices (F-3) also exhibited pH-dependent swelling and drug release patterns. Furthermore, these matrices evidenced a slower biodegradability as compared to the reference composites (F-1,0% MMT). The mucin adsorption ability of matrices followed the Freundlich isotherm. The matrices (F-3) also displayed enhanced anti-proliferative and apoptosis-inducing potentials on TNBC cells relative to pure ERL. Thus, the GG/CFSM-based IPN matrices could be employed as efficient drug delivery vehicles for breast cancer therapy.

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Nayak AK, Ansari MT, Sami F, Bera H, Hasnain MS (2019) Cashew gum in drug delivery applications. In: Hasnain MS, Nayak AK (eds) Natural polysaccharides in drug delivery and biomedical applications. Academic Press, London, pp 263–283CrossRef

Nayak AK, Bera H (2019) In situ polysaccharide-based gels for topical drug delivery applications. In: Maiti S, Jana S (eds) Polysaccharide carriers for drug delivery. Woodhead Publishing, Duxford, pp 615–638CrossRef

Bera H, Abbasi YF, Gajbhiye V, Liew KF, Kumar P, Tambe P et al (2020) Carboxymethyl fenugreek galactomannan-g-poly(N-isopropylacrylamide-co-N, N′-methylene-bis-acrylamide)-clay based pH/temperature-responsive nanocomposites as drug-carriers. Mater Sci Eng C 110:110628. https://doi.org/10.1016/j.msec.2020.110628CrossRef

Bera H, Abbasi YF, Lee Ping L, Marbaniang D, Mazumder B, Kumar P et al (2020) Erlotinib-loaded carboxymethyl temarind gum semi-interpenetrating nanocomposites. Carbohydr Polym 230:115664. https://doi.org/10.1016/j.carbpol.2019.115664CrossRefPubMed

Nayak AK, Pal D, Das S (2013) Calcium pectinate-fenugreek seed mucilage mucoadhesive beads for controlled delivery of metformin HCl. Carbohydr Polym 96(1):349–357. https://doi.org/10.1016/j.carbpol.2013.03.088CrossRefPubMed

Nayak AK, Pal D, Santra K (2014) Development of calcium pectinate-tamarind seed polysaccharide mucoadhesive beads containing metformin HCl. Carbohydr Polym 101:220–230. https://doi.org/10.1016/j.carbpol.2013.09.024CrossRefPubMed

Bera H, Abbasi YF, Yoke FF, Seng PM, Kakoti BB, Ahmmed SKM, Bhatnagar P (2019) Ziprasidone-loaded arabic gum modified montmorillonite-tailor-made pectin based gastroretentive composites. Int J Biol Macromol 129:552–563. https://doi.org/10.1016/j.ijbiomac.2019.01.171CrossRefPubMed

del Real A, Wallander D, Maciel A, Cedillo G, Loza H (2015) Graft copolymerization of ethyl acrylate onto tamarind kernel powder, and evaluation of its biodegradability. Carbohydr Polym 117:11–18. https://doi.org/10.1016/j.carbpol.2014.09.044CrossRefPubMed

Nagaraja K, Rao KM, Rao KSVK, Han SS (2022) Dual responsive tamarind gum-co-poly(N-isopropyl acrylamide-co-ethylene glycol vinyl ether) hydrogel: a promising device for colon specific anti-cancer drug delivery. Colloids Surf A Physicochem Eng 641:128456. https://doi.org/10.1016/j.colsurfa.2022.128456CrossRef

10.

Ma J, Zhang L, Fan B, Xu Y, Liang B (2008) A novel sodium carboxymethylcellulose/poly(N-isopropylacrylamide)/Clay semi-IPN nanocomposite hydrogel with improved response rate and mechanical properties. J Polym Sci B Polym Phys 46(15):1546–1555. https://doi.org/10.1002/polb.21490CrossRef

11.

Wilpiszewska K, Antosik AK, Spychaj T (2015) Novel hydrophilic carboxymethyl starch/montmorillonite nanocomposite films. Carbohydr Polym 128:82–89. https://doi.org/10.1016/j.carbpol.2015.04.023CrossRefPubMed

12.

Bera H, Abbasi YF, Thakur A (2023) Curdlan/clay nanocomposite-reinforced alginate beads as drug carriers. J Polym Environ. https://doi.org/10.1007/s10924-023-03036-0CrossRef

13.

Ramezanian S, Moghaddas J, Roghani-Mamaqani H, Rezamand A (2023) Dual pH- and temperature-responsive poly(dimethylaminoethyl methacrylate)-coated mesoporous silica nanoparticles as a smart drug delivery system. Sci Rep 13(1):20194. https://doi.org/10.1038/s41598-023-47026-7CrossRefPubMedPubMedCentral

14.

Bera H, Abbasi YF, Gajbhiye V, Ping LL, Salve R, Kumar P et al (2021) Chemosensitivity assessments of curdlan-doped smart nanocomposites containing erlotinib HCl. Int J Biol Macromol 181:169–179. https://doi.org/10.1016/j.ijbiomac.2021.03.152CrossRefPubMed

15.

Ghorbani M, Nezhad-Mokhtari P, Mahmoodzadeh F (2021) Incorporation of oxidized pectin to reinforce collagen/konjac glucomannan hydrogels designed for tissue engineering applications. Macromol Res 29(4):289–296CrossRef

16.

Erfani A, Flynn NH, Aichele CP, Ramsey JD (2020) Encapsulation and delivery of protein from within poly (sulfobetaine) hydrogel beads. J Appl Polym Sci 137(40):49550. https://doi.org/10.1002/app.49550CrossRef

17.

Wright L, Joyce P, Barnes TJ, Prestidge CA (2021) Mimicking the gastrointestinal mucus barrier: laboratory-based approaches to facilitate an enhanced understanding of mucus permeation. ACS Biomater Sci Eng. https://doi.org/10.1021/acsbiomaterials.1c00814CrossRefPubMed

18.

Kevadiya BD, Rajkumar S, Bajaj HC, Chettiar SS, Gosai K, Brahmbhatt H et al (2014) Biodegradable gelatin–ciprofloxacin–montmorillonite composite hydrogels for controlled drug release and wound dressing application. Colloids Surf B 122:175–183. https://doi.org/10.1016/j.colsurfb.2014.06.051CrossRef

19.

Gerlier D, Thomasset N (1986) Use of MTT colorimetric assay to measure cell activation. J Immunol Methods 94(1):57–63. https://doi.org/10.1016/0022-1759(86)90215-2CrossRefPubMed

20.

Krey JF, Drummond M, Foster S, Porsov E, Vijayakumar S, Choi D et al (2016) Annexin A5 is the most abundant membrane-associated protein in stereocilia but is dispensable for hair-bundle development and function. Sci Rep 6(1):27221. https://doi.org/10.1038/srep27221CrossRefPubMedPubMedCentral

21.

Chakka VP, Zhou T (2020) Carboxymethylation of polysaccharides: synthesis and bioactivities. Int J Biol Macromol 165:2425–2431. https://doi.org/10.1016/j.ijbiomac.2020.10.178CrossRefPubMed

22.

Ganguly S, Maity T, Mondal S, Das P, Das NC (2017) Starch functionalized biodegradable semi-IPN as a pH-tunable controlled release platform for memantine. Int J Biol Macromol 95:185–198. https://doi.org/10.1016/j.ijbiomac.2016.11.055CrossRefPubMed

23.

Guo H, de Magalhaes GM, Ducouret G, Hourdet D (2018) Cold and hot gelling of alginate-graft-PNIPAM: a schizophrenic behavior induced by potassium salts. Biomacromol 19(2):576–587. https://doi.org/10.1021/acs.biomac.7b01667CrossRef

24.

Wu C, Peng S, Wen C, Wang X, Fan L, Deng R, Pang J (2012) Structural characterization and properties of konjac glucomannan/curdlan blend films. Carbohydr Polym 89(2):497–503. https://doi.org/10.1016/j.carbpol.2012.03.034CrossRefPubMed

25.

Huang X, Ge M, Wang H, Liang H, Meng N, Zhou N (2022) Functional modification of polydimethylsiloxane nanocomposite with silver nanoparticles-based montmorillonite for antibacterial applications. Colloids Surf A Physicochem Eng 642:128666. https://doi.org/10.1016/j.colsurfa.2022.128666CrossRef

26.

Yang F, Xia S, Tan C, Zhang X (2013) Preparation and evaluation of chitosan-calcium-gellan gum beads for controlled release of protein. Eur Food Res Technol 237(4):467–479. https://doi.org/10.1007/s00217-013-2021-yCrossRef

27.

Bulut E (2021) Development and optimization of Fe3+-crosslinked sodium alginate-methylcellulose semi-interpenetrating polymer network beads for controlled release of ibuprofen. Int J Biol Macromol 168:823–833. https://doi.org/10.1016/j.ijbiomac.2020.11.147CrossRefPubMed

28.

Pongjanyakul T, Rongthong T (2010) Enhanced entrapment efficiency and modulated drug release of alginate beads loaded with drug–clay intercalated complexes as microreservoirs. Carbohydr Polym 81(2):409–419. https://doi.org/10.1016/j.carbpol.2010.02.038CrossRef

29.

Gomes RF, Lima LRM, Feitosa JPA, Paula HCB, de Paula RCM (2020) Influence of galactomannan molar mass on particle size galactomannan-grafted-poly-N-isopropylacrylamide copolymers. Int J Biol Macromol 156:446–453. https://doi.org/10.1016/j.ijbiomac.2020.04.004CrossRefPubMed

30.

Rampaka R, Ommi K, Chella N (2021) Role of solid lipid nanoparticles as drug delivery vehicles on the pharmacokinetic variability of erlotinib HCl. J Drug Deliv Sci Technol 66:102886. https://doi.org/10.1016/j.jddst.2021.102886CrossRef

31.

Gontijo SML, Guimarães PPG, Viana CTR, Denadai ÂML, Gomes ADM, Campos PP et al (2015) Erlotinib/hydroxypropyl-β-cyclodextrin inclusion complex: characterization and in vitro and in vivo evaluation. J Incl Phenom Macrocycl Chem 83(3):267–279. https://doi.org/10.1007/s10847-015-0562-3CrossRef

32.

Yadav H, Agrawal R, Panday A, Patel J, Maiti S (2022) Polysaccharide-silicate composite hydrogels: review on synthesis and drug delivery credentials. J Drug Deliv Sci Technol 74:103573. https://doi.org/10.1016/j.jddst.2022.103573CrossRef

33.

Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ et al (2012) Drug absorption interactions between oral targeted anticancer agents and PPIs: Is pH-dependent solubility the Achilles heel of targeted therapy? Clin Pharmacol Ther 92(2):203–213. https://doi.org/10.1038/clpt.2012.73CrossRefPubMed

34.

Park JH, Shin HJ, Kim MH, Kim JS, Kang N, Lee JY et al (2016) Application of montmorillonite in bentonite as a pharmaceutical excipient in drug delivery systems. J Pharm Investig 46(4):363–375. https://doi.org/10.1007/s40005-016-0258-8CrossRefPubMedPubMedCentral

35.

Singh B, Sharma V, Chauhan D (2010) Gastroretentive floating sterculia–alginate beads for use in antiulcer drug delivery. Chem Eng Res Des 88(8):997–1012. https://doi.org/10.1016/j.cherd.2010.01.017CrossRef

36.

Bazban-Shotorbani S, Hasani-Sadrabadi MM, Karkhaneh A, Serpooshan V, Jacob KI, Moshaverinia A, Mahmoudi M (2017) Revisiting structure-property relationship of pH-responsive polymers for drug delivery applications. J Control Release 253:46–63. https://doi.org/10.1016/j.jconrel.2017.02.021CrossRefPubMed

37.

Fernando IPS, Lee W, Han EJ, Ahn G (2020) Alginate-based nanomaterials: fabrication techniques, properties, and applications. J Chem Eng 391:123823. https://doi.org/10.1016/j.cej.2019.123823CrossRef

38.

Pavani P, Kumar K, Rani A, Venkatesu P, Lee M-J (2021) The influence of sodium phosphate buffer on the stability of various proteins: insights into protein-buffer interactions. J Mol Liq 331:115753. https://doi.org/10.1016/j.molliq.2021.115753CrossRef

39.

Wang D, Lv R, Ma X, Zou M, Wang W, Yan L et al (2018) Lysozyme immobilization on the calcium alginate film under sonication: development of an antimicrobial film. Food Hydrocoll 83:1–8. https://doi.org/10.1016/j.foodhyd.2018.04.021CrossRef

40.

Sosnik A, Das Neves J, Sarmento B (2014) Mucoadhesive polymers in the design of nano-drug delivery systems for administration by non-parenteral routes: a review. Prog Polym Sci 39(12):2030–2075. https://doi.org/10.1016/j.progpolymsci.2014.07.010CrossRef

41.

García-Guzmán P, Medina-Torres L, Calderas F, Bernad-Bernad MJ, Gracia-Mora J, Marcos X et al (2019) Rheological mucoadhesion and cytotoxicity of montmorillonite clay mineral/hybrid microparticles biocomposite. Appl Clay Sci 180:105202. https://doi.org/10.1016/j.clay.2019.105202CrossRef

42.

Sorasitthiyanukarn FN, Muangnoi C, Thaweesest W, Rojsitthisak P, Rojsitthisak P (2019) Enhanced cytotoxic, antioxidant and anti-inflammatory activities of curcumin diethyl disuccinate using chitosan-tripolyphosphate nanoparticles. J Drug Deliv Sci Technol 53:101118. https://doi.org/10.1016/j.jddst.2019.06.015CrossRef

43.

Yamasaki F, Zhang D, Bartholomeusz C, Sudo T, Hortobagyi GN, Kurisu K, Ueno NT (2007) Sensitivity of breast cancer cells to erlotinib depends on cyclin-dependent kinase 2 activity. Mol Cancer Ther 6(8):2168–2177. https://doi.org/10.1158/1535-7163.Mct-06-0514CrossRefPubMedPubMedCentral

44.

Upadhyay M, Adena SKR, Vardhan H, Yadav SK, Mishra B (2019) Locust bean gum and sodium alginate based interpenetrating polymeric network microbeads encapsulating capecitabine: improved pharmacokinetics, cytotoxicity & in vivo antitumor activity. Mater Sci Eng C 104:109958. https://doi.org/10.1016/j.msec.2019.109958CrossRef

45.

Vaidya B, Parvathaneni V, Kulkarni NS, Shukla SK, Damon JK, Sarode A et al (2019) Cyclodextrin modified erlotinib loaded PLGA nanoparticles for improved therapeutic efficacy against non-small cell lung cancer. Int J Biol Macromol 122:338–347. https://doi.org/10.1016/j.ijbiomac.2018.10.181CrossRefPubMed

Title: Erlotinib-entrapped gellan gum/carboxymethyl fenugreek seed mucilage-based thermo/pH-sensitive matrices
Authors: Yasir Faraz Abbasi
Hriday Bera
Abhimanyu Thakur
Publication date: 07-04-2024
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-024-05240-x

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