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Polymer Bulletin
Published in: Polymer Bulletin 1/2021

07-01-2020 | Original Paper

Formulation and evaluation of interpenetrating network of xanthan gum and polyvinylpyrrolidone as a hydrophilic matrix for controlled drug delivery system

Authors: Maryam Anwar, Fahad Pervaiz, Hina Shoukat, Sobia Noreen, Kanwal Shabbir, Asma Majeed, Saba Ijaz

Published in: Polymer Bulletin | Issue 1/2021

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Abstract

The prime objective of the present study was to develop novel colon targeting xanthan gum/polyvinylpyrrolidone-co-poly acrylic acid hydrogels for controlled delivery of 5-fluorouracil at colon-specific site by combining the properties of natural and synthetic polymers. Xanthan gum (XG) and polyvinylpyrrolidone (PVP) polymer have been chemically cross-linked with acrylic acid (AA) monomer using ethylene glycol dimethacrylate and ammonium per sulfate/sodium hydrogen sulfite as a cross-linker and initiator, respectively. Different proportions of XG, PVP, acrylic acid and ethylene glycol dimethacrylate were blended with each other to fabricate pH-sensitive hydrogels by free radical polymerization. SEM, FTIR, TGA, DSC, XRD and sol−gel fraction analysis were carried out for characterization and structural analysis of polymeric system. pH-responsive behavior of fabricated hydrogels was investigated by performing swelling studies and in vitro drug release studies at both pH 1.2 and pH 7.4. Toxicity studies were performed on rabbits to evaluate cytotoxicity and biocompatibility. TGA and DSC confirmed that formulations were thermodynamically stable, while FTIR, SEM and XRD revealed the successful grafting of components. By increasing the content of polymer, monomer and cross-linker, gel fraction was found to be increased. Swelling capacity of hydrogels increases with the increase in concentration of monomer, while swelling capacity tends to decreases with the increase in concentration of cross-linker and polymer in hydrogel composition. pH sensitivity of hydrogels was confirmed by swelling dynamic and drug release behavior in simulated gastrointestinal fluids. Toxicity studies confirmed that hydrogels were non-toxic. Drug release kinetics revealed the controlled release pattern of 5-fluorouracil in developed polymeric network. Cross-linked XG/PVP-co-poly (AA) hydrogels can be used as promising candidate for controlled delivery of 5-FU for prolonged treatment period at colon-specific site.
previous article Plasticized solid polymer electrolyte based on triblock copolymer poly(vinylidene chloride-co-acrylonitrile-co-methyl methacrylate) for magnesium ion batteries
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Metadata
Title
Formulation and evaluation of interpenetrating network of xanthan gum and polyvinylpyrrolidone as a hydrophilic matrix for controlled drug delivery system
Authors
Maryam Anwar
Fahad Pervaiz
Hina Shoukat
Sobia Noreen
Kanwal Shabbir
Asma Majeed
Saba Ijaz
Publication date
07-01-2020
Publisher
Springer Berlin Heidelberg
Published in
Polymer Bulletin / Issue 1/2021
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI
https://doi.org/10.1007/s00289-019-03092-4

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