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01-11-2014 | Research Paper

Gold nanoparticles induce DNA damage in the blood and liver of rats

Authors: Eria Cardoso, Eduardo Londero, Gabriela Kozuchovski Ferreira, Gislaine Tezza Rezin, Elton Torres Zanoni, Frederico de Souza Notoya, Daniela Dimer Leffa, Adriani Paganini Damiani, Francine Daumann, Paula Rohr, Luciano da Silva, Vanessa M. Andrade, Marcos Marques da Silva Paula

Published in: Journal of Nanoparticle Research | Issue 11/2014

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Abstract

The potential of gold nanoparticles (GNPs) for use in different biological applications has led to a strong interest in the study of their possible deleterious effects in biological systems and how these effects may be mitigated. This study was undertaken to investigate the effects of the acute and chronic administration of GNPs with mean diameters of 10 and 30 nm on deoxyribonucleic acid (DNA) damage in the blood and liver of adult rats. For the acute administration, Wistar adult rats received a single intraperitoneal injection of either GNPs or a saline solution. For the chronic administration, Wistar adult rats received a daily single injection of the same GNPs or saline solution for 28 days. Twenty-four hours after either the single (acute) or final injection (chronic), the rats were euthanised by decapitation, and the blood and liver were isolated for the evaluation of DNA damage. In this study, we demonstrated that the acute and chronic administration of GNPs 10 and 30 nm in size increased the frequency of DNA damage and the damage index in the blood and liver of adult rats. These findings suggest that the DNA damage may be caused by oxidative stress, which occurred regardless of the type of administration and GNP size.

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Title: Gold nanoparticles induce DNA damage in the blood and liver of rats
Authors: Eria Cardoso
Eduardo Londero
Gabriela Kozuchovski Ferreira
Gislaine Tezza Rezin
Elton Torres Zanoni
Frederico de Souza Notoya
Daniela Dimer Leffa
Adriani Paganini Damiani
Francine Daumann
Paula Rohr
Luciano da Silva
Vanessa M. Andrade
Marcos Marques da Silva Paula
Publication date: 01-11-2014
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2014
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-014-2727-1

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