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01-02-2013 | Original Paper

Hemostatic efficacy and tissue reaction of oxidized regenerated cellulose hemostats

Authors: Richard W. Hutchinson, Kavita George, Doug Johns, Lee Craven, Gary Zhang, Pullen Shnoda

Published in: Cellulose | Issue 1/2013

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Abstract

Oxidized regenerated cellulose (ORC) has been used as an absorbable hemostat since World War II. In the present study, hemostasis time was determined in a spleen incision model in swine. The effect of mass on absorbable hemostat efficacy and hemostasis time was evaluated by standardizing the ORC materials on a mass basis. The median hemostasis time for a single layer of the new nonwoven ORC was as much as 51 % shorter than woven ORC (P < 0.001). The mean hemostasis time for nonwoven ORC was not affected by the mass of hemostat applied to the wound. The hemostatic efficacy of woven ORC increased with the mass (layers) of hemostat applied to the wound. Nonwoven ORC is significantly faster in achieving hemostasis than woven ORC, and its hemostatic efficacy is not influenced by the mass of material applied. Tissue reaction was minimal and the material was fully absorbed by 14 days.

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Title: Hemostatic efficacy and tissue reaction of oxidized regenerated cellulose hemostats
Authors: Richard W. Hutchinson
Kavita George
Doug Johns
Lee Craven
Gary Zhang
Pullen Shnoda
Publication date: 01-02-2013
Publisher: Springer Netherlands
Published in: Cellulose / Issue 1/2013
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-012-9828-8

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