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26-10-2019 | Original Research

Improvement of platelet aggregation and rapid induction of hemostasis in chitosan dressing using silver nanoparticles

Authors: Guangqian Lan, Qing Li, Fei Lu, Kun Yu, Bitao Lu, Rong Bao, Fangyin Dai

Published in: Cellulose | Issue 1/2020

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Abstract

There is an increasing demand for high-performance hemostatic agents with good antibacterial efficiency and biocompatibility. In this study, a chitosan/gelatin/sodium hyaluronate hemostatic dressing with silver nanoparticles (CGSH/Ag50) was designed and characterized. Our results suggest that CGSH/Ag50 has high blood absorption and promotes platelet aggregation by the activation of positively charged surface and stimulation of silver nanoparticles. Owing to these excellent properties, CGSH/Ag50 could rapidly control hemorrhage in rabbit ear and liver injury models. CGSH/Ag50 also shows good antibacterial activity, good liquid absorption, and significantly promotes full-thickness wound healing. In the hemolysis and L929 cell cytotoxicity assays, CGSH/Ag50 exhibited no cytotoxicity, suggesting good hemocompatibility and biocompatibility. These observations suggest that CGSH/Ag50 can be an efficient hemostatic material with enough biocompatibility to be used for controlling hemorrhage and promoting wound healing after hemostasis surgery.

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Title: Improvement of platelet aggregation and rapid induction of hemostasis in chitosan dressing using silver nanoparticles
Authors: Guangqian Lan
Qing Li
Fei Lu
Kun Yu
Bitao Lu
Rong Bao
Fangyin Dai
Publication date: 26-10-2019
Publisher: Springer Netherlands
Published in: Cellulose / Issue 1/2020
Print ISSN: 0969-0239
Electronic ISSN: 1572-882X
DOI: https://doi.org/10.1007/s10570-019-02795-1

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