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Journal of Materials Science
Published in: Journal of Materials Science 4/2018

26-10-2017 | Biomaterials

In vitro degradation and bioactivity of composite poly-l-lactic (PLLA)/bioactive glass (BG) scaffolds: comparison of 45S5 and 1393BG compositions

Authors: Gioacchino Conoscenti, Francesco Carfì Pavia, Francesca Elisa Ciraldo, Liliana Liverani, Valerio Brucato, Vincenzo La Carrubba, Aldo R. Boccaccini

Published in: Journal of Materials Science | Issue 4/2018

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Abstract

The objective of this study was to compare the effect of two bioglass (BG) compositions 45S5 and 1393 in poly-l-lactic composite scaffolds in terms of morphology, mechanical properties, biodegradation, water uptake and bioactivity. The scaffolds were produced via thermally induced phase separation starting from a ternary polymer solution (polymer/solvent/non-solvent). Furthermore, different BG to polymer ratios have been selected (1, 2.5, 5% wt/wt) to evaluate the effect of the amount of filler on the composite structure. Results show that the addition of 1393BG does not affect the scaffold morphology, whereas the 45S5BG at the highest amount tends to appreciably modify the scaffold architecture interacting with the phase separation process. Bioactivity tests confirmed the formation of a hydroxycarbonateapatite-layer in both types of BGs (detected via scanning electron microscopy, X-ray diffractometry and Fourier Transform Infrared Spectroscopy). Overall, the results showed that 1393BG composition affects the experimental preparation protocol to a minimal extent thus allowing a better control of the scaffold’s morphology compared to 45S5BG.
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Metadata
Title
In vitro degradation and bioactivity of composite poly-l-lactic (PLLA)/bioactive glass (BG) scaffolds: comparison of 45S5 and 1393BG compositions
Authors
Gioacchino Conoscenti
Francesco Carfì Pavia
Francesca Elisa Ciraldo
Liliana Liverani
Valerio Brucato
Vincenzo La Carrubba
Aldo R. Boccaccini
Publication date
26-10-2017
Publisher
Springer US
Published in
Journal of Materials Science / Issue 4/2018
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-017-1743-9

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