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2020 | OriginalPaper | Chapter

8. In Vitro Degradation Test of Gd-, Si-Substituted Hydroxyapatite

Authors : Elizaveta A. Mukhanova, Ekaterina S. Ivanyutina, Maxim Yu. Stupko, Irina V. Rybal’chenko

Published in: Modeling, Synthesis and Fracture of Advanced Materials for Industrial and Medical Applications

Publisher: Springer International Publishing

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Abstract

Synthetic hydroxyapatite is involved in osteogenesis when using as an implant. Different substitutions in the hydroxyapatite (HAp) can change the low rate of degradation and solubility of pure hydroxyapatite as well as other physical, chemical, and biological properties. We synthesized single-phase Ca₈Gd₂(PO₄)₄(SiO₄)₂(OH)₂ (Gd, Si-HAp) by coprecipitation and investigated its behavior in model solutions: water, simulated body fluid and physiological saline solution (0.9% NaCl). Morphology of samples before and after degradation confirmed that flake-like crystals of initial Gd, Si-HAp is a preferable form for the further precipitation of HAp crystals with needle-like morphology the same as in human body. The degradation rate of substituted Gd, Si-HAp in comparison with pure HAp is higher in different solutions and the rate of nucleation is apparently slower as we can see in a series of in vitro degradation tests.

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Title: In Vitro Degradation Test of Gd-, Si-Substituted Hydroxyapatite
Authors: Elizaveta A. Mukhanova
Ekaterina S. Ivanyutina
Maxim Yu. Stupko
Irina V. Rybal’chenko
Publisher: Springer International Publishing
Book: Modeling, Synthesis and Fracture of Advanced Materials for Industrial and Medical Applications
Print ISBN: 978-3-030-48160-5

Electronic ISBN: 978-3-030-48161-2

Copyright Year: 2020
DOI: https://doi.org/10.1007/978-3-030-48161-2_8

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