Magnetic mesoporous silica: a novel nano-material towards electrochemical sensing

This study reports on the synthesis and characterization of a novel magnetic nano-material, Fe₃O₄ magnetic nanoparticles/mobile crystalline material-41 (Fe₃O₄ MNP-MCM-41) for sensing some cardiovascular drugs. For the first time, as-synthesized Fe₃O₄ MNP-MCM-41 is engineered to specifically and effectively capture and enhancement the electrochemical signals of some cardiovascular drugs at different pH due to the synergy among MCM-41 and magnetic nanoparticles. We have illustrated that the as-obtained Fe₃O₄ MNP-MCM-41 exhibited a much higher electroactivity individual bare carbon past electrode (CPE) for the electrooxidation and detection of selected cardiovascular drugs. Magnetic and specific properties of the Fe₃O₄ MNP-MCM-41 can be exploited to capture and pre-concentration the selected cardiovascular drugs onto its surface, which are important for detection of multi-drugs. The proposed method was successfully applied to determine selected drugs in human serum, yielding satisfactory results. In general, Fast response time, excellent catalytic activity, lower overvoltage and ease of preparation are the advantages of the proposed nano-sensor.