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Published in:
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2015 | Online First | Chapter

Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis

Authors : Robbert Hoogeboom, Pavel Tolar

Published in: Current Topics in Microbiology and Immunology

Publisher: Springer International Publishing

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Abstract

Generation of high-affinity, protective antibodies requires B cell receptor (BCR) signaling, as well as antigen internalization and presentation to helper T cells. B cell antigen internalization is initiated by antigen capture, either from solution or from immune synapses formed on the surface of antigen-presenting cells, and proceeds via clathrin-dependent endocytosis and intracellular routing to late endosomes. Although the components of this pathway are still being discovered, it has become clear that antigen internalization is actively regulated by BCR signaling at multiple steps and, vice versa, that localization of the BCR along the endocytic pathway modulates signaling. Accordingly, defects in BCR internalization or trafficking contribute to enhanced B cell activation in models of autoimmune diseases and in B cell lymphomas. In this review, we discuss how BCR signaling complexes regulate each of the steps of this endocytic process and why defects along this pathway manifest as hyperactive B cell responses in vivo.
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Metadata
Title
Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis
Authors
Robbert Hoogeboom
Pavel Tolar
Copyright Year
2015
Publisher
Springer International Publishing
DOI
https://doi.org/10.1007/82_2015_476