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2019 | OriginalPaper | Chapter

Molecular Mechanisms of Heavy Metal Toxicity in Cancer Progression

Authors : Pragati Singh, Deepak Tiwari, Manish Mishra, Dhruv Kumar

Published in: Networking of Mutagens in Environmental Toxicology

Publisher: Springer International Publishing

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Abstract

In last few years, cancer became one of the leading cause of death in humans. There are several factors associated with the cancer initiation and progression including heavy metals. Several heavy metals including arsenic, cadmium, uranium, lead, mercury etc. and heavy metal-containing compounds are toxic to the humans and have been reported to induce mutations in human genome which further leads to the carcinogenesis. This chapter provides the detail understanding of molecular mechanisms and pathway analysis to heavy metal toxicity in human carcinogenesis.

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Adenocarcinoma B, Tchounwou CK, Yedjou CG, Farah I, Tchounwou PB (2014) NIH Public Access 601:156–160

AERB (2004) Drinking water specifications in India. Retrieved from Mumbai: www.aerb.gov.in

Al-azzawie HF, Umran A, Hyader NH (2013) Oxidative stress, antioxidant status and DNA damage in a mercury exposure workers. Br J Pharmacol Toxicol 4:80–88CrossRef

Al-fartusie FS, Mohssan SN (2017) Essential trace elements and their vital roles in human body. Indian J Adv Chem Sci 5(3):127–136

Alfvén T, Elinder CG, Carlsson MD, Grubb A, Hellström L, Persson B, Järup L (2000) Low-level cadmium exposure and osteoporosis. J Bone Miner Res 15(8):1579–1586CrossRef

Alghazal MA, Lenártová V, Holovská K, Sobeková A, Falis M, Legáth J (2008) Activities of antioxidant and detoxifying enzymes in rats after lead exposure. Acta Vet Brno 77(3):347–354CrossRef

Appenroth K (2010) Definition of “ Heavy Metals” and their role in biological systems. In: Soil heavy metals. Soil biology, vol 19. Springer, Berlin, pp 19–30

Arif N, Yadav V, Singh S, Singh S, Ahmad P, Mishra RK et al (2016) Influence of high and low levels of plant-beneficial heavy metal ions on plant growth and development. Front Environ Sci 4:69

Awasthi S, Awasthi R, Pande VK, Srivastav RC, Frumkin H (1996) Blood lead in pregnant women in the urban slums of Lucknow, India. Occup Environ Med 53(12):836–840CrossRef

Ayandiran TA, Fawole O, Adewoye SO, Ogundiran M (2009) Bioconcentration of metals in the body muscle and gut of Clarias gariepinus exposed to sublethal concentrations of soap and detergent effluent. J Cell Anim Biol 3(8):113–118

Aziz HA, Adlan MN, Ariffin KS (2008) Heavy metals (Cd, Pb, Zn, Ni, Cu and Cr(III)) removal from water in Malaysia: post treatment by high quality limestone. Biores Technol 99(6):1578–1583CrossRef

Bajwa BS, Kumar S, Singh S, Sahoo SK, Tripathi RM (2017) Uranium and other heavy toxic elements distribution in the drinking water samples of SW-Punjab, India. J Radiat Res Appl Sci 10(1):13–19CrossRef

Barnes J (2003) Quality, efficacy and safety of complementary medicines: fashions, facts and the future. Part 1: regulation and quality. Br J Clin Pharmacol 55:226–233CrossRef

Barra R, Colombo JC, Eguren G, Gamboa N, Jardim WF, Mendoza G (2006) Persistent organic pollutants (POPs) in eastern and western South American countries. In: Reviews of environmental contamination and toxicology. Springer, New York, NY, pp 1–33

Basu A, Mahata J, Gupta S, Giri AK (2001) Genetic toxicology of a paradoxical human carcinogen, arsenic: a review. Mutat Res Rev Mutat Res 488(2):171–194CrossRef

Brindha K, Elango L (2013) Occurrence of uranium in groundwater of a shallow granitic aquifer and its suitability for domestic use in southern India. J Radioanal Nucl Chem 295(1):357–367CrossRef

Brochin R, Leone S, Phillips D, Shepard N, Zisa D, Angerio A (2008) The cellular effect of lead poisoning and its clinical picture. Georgetown Undergraduate J Health Sci 5(2):1–8

Browning C, The T, Mason M, Wise JP (2014) Titanium dioxide nanoparticles are not cytotoxic or clastogenic in human skin cells. J Environ Anal Toxicol 4(6):1–15CrossRef

Chioma O, Emmanuel A, Peter A (2017) Accumulation and toxicological risk assessment of Cd, As, Pb, Hg, and Cu from topsoils of school playgrounds at Obio-Akpor LGA Rivers State Nigeria. Int J Sci World 5(1):38CrossRef

Clarkson TW (1993) Molecular and ionic mimicry of toxic metals. Annu Rev Pharmacol Toxicol 33(1):545–571CrossRef

Clarkson TW, Magos L (2006) The toxicology of mercury and its chemical compounds. Crit Rev Toxicol 36(8):609–662CrossRef

Cosyns JP, Jadoul M, Squifflet JP, Wese FX, De Strihou CVY (1999) Urothelial lesions in Chinese-herb nephropathy. Am J Kidney Dis 33(6):1011–1017CrossRef

Dayan AD, Paine AJ (2001) Mechanisms of chromium toxicity, carcinogenicity and allergenicity: review of the literature from 1985 to 2000. Hum Exp Toxicol 20(9):439–451CrossRef

Dong Z (2002) The molecular mechanisms of arsenic-induced cell transformation and apoptosis. Environ Health Perspect 110(SUPPL. 5):757–759CrossRef

Duffus JH (2002) “Heavy Metals”—a meaningless term? (IUPAC technical report). Pure Appl Chem 74(5):793–807 [National Representatives: Z. Bardodej (Czech Republic) J. Park (Korea) F. J. R. Paumgartten (Brazil)]CrossRef

Duruibe JO, Ogwuegbu MO, Egwurugwu JN (2007) Heavy metal pollution and human biotoxic effects. Int J Phys Sci 2(5):112–118

Efstathiou M, Aristarchou T, Kiliari T, Demetriou A, Pashalidis I (2014) Seasonal variation, chemical behavior and kinetics of uranium in an unconfined groundwater system. J Radioanal Nucl Chem 299(1):171–175CrossRef

Ernst E (2002) Adulteration of Chinese herbal medicines with synthetic drugs: a systematic review. J Intern Med 252(2):107–113CrossRef

Ernst E (2004) Prescribing herbal medications appropriately. J Fam Pract 53(12):985–988

Florea AM, Büsselberg D, Carpenter D (2012) Metals and disease. J Toxicol 2012:2012–2014CrossRef

Gokhale BSL (2008) Groundwater Radon-222 concentrations in Antelope Creek, Idaho: measurement and interpolation. Open Environ Bio Monit J 3:12–20CrossRef

Gómez P, Garralón A, Buil B, Turrero MJ, Sánchez L, de la Cruz B (2006) Modeling of geochemical processes related to uranium mobilization in the groundwater of a uranium mine. Sci Total Environ 366(1):295–309CrossRef

Goulart M, Batoréu MC, Rodrigues AS, Laires A, Rueff J (2005) Lipoperoxidation products and thiol antioxidants in chromium exposed workers. Mutagenesis 20(5):311–315CrossRef

Goyer RA (1993) Lead toxicity: current concerns. Environ Health Perspect 100:177–187CrossRef

Goyer R, Golub M, Choudhury H, Hughes M, Kenyon E, Stifelman M (2004) Issue paper on the human health effects of metals. In: US environmental protection agency risk assessment forum, vol 1200

Grimsrud TK, Peto J (2006) Persisting risk of nickel related lung cancer and nasal cancer among clydach refiners. Occup Environ Med 63(5):365–366CrossRef

Griswold W, Martin S (2009) Human health effects of heavy metals. Environ Sci Technol 15:1–6

Hartmann HM, Monette FA, Avci HI (2000) Overview of toxicity data and risk assessment methods for evaluating the chemical effects of depleted uranium compounds. Hum Ecol Risk Assess 6(5):851–874CrossRef

Heipieper HJ, Meulenbeld G, Van Oirschot Q, De Bont JAM (1996) Effect of environmental factors on the trans/cis ratio of unsaturated fatty acids in pseudomonas putida S12. Appl Environ Microbiol 62(8):2773–2777

Hodson ME (2004) Heavy metals—geochemical bogey men? Environ Pollut 129(3):341–343CrossRef

Hong YS, Song KH, Chung JY (2014) Health effects of chronic arsenic exposure. J Prev Med Public Health 47(5):245–252CrossRef

Hotz P, Buchet JP, Bernard A, Lison D, Lauwerys R (1999) Renal effects of low-level environmental cadmium exposure: 5-year follow-up of a subcohort from the cadmibel study. Lancet 354:1508–1513CrossRef

Hu Z, Gao S (2008) Upper crustal abundances of trace elements: a revision and update. Chem Geol 253(3):205–221CrossRef

IAEA (2015) Protection of the public against exposure indoors due to radon and other natural sources of radiation. In: IAEA safety standards for protecting people and the environment, vol SSG-32. IAEA, Vienna, p 112

IARC (2006) Inorganic and organic lead. IARC monographs on the evaluation of carcinogenic risks to humans, 87

Ilyin I, Berg T, Dutchak S, Pacyna J (2004) Heavy metals. EMEP assessment part I European perspective. Norwegian Meteorological Institute, Oslo, Norway, pp 107–128

Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals. Interdisc Toxicol 7(2):60–72CrossRef

Jan AT, Azam M, Siddiqui K, Ali A, Choi I, Haq QMR (2015) Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants. Int J Mol Sci 16(12):29592–29630CrossRef

Järup L (2003) Hazards of heavy metal contamination. Br Med Bull 68:167–182CrossRef

Jarup L, Persson B, Elinder CG (1995) Decreased glomerular filtration rate in solderers exposed to cadmium. Occup Environ Med 52(12):818–822CrossRef

Jhaa N, Noditi M, Nilsson R, Natarajana T (1992) Genotoxic effects of sodium arsenite on human cells. Mutat Res 284(2):215–221CrossRef

Kaul B, Sandhu RS, Depratt C, Reyes F (1999) Follow-up screening of lead-poisoned children near an auto battery recycling plant, Haina, Dominican Republic. Environ Health Perspect 107(11):917–920CrossRef

Kawada T (2016) Predictive validity of a specific questionnaire for psychiatric morbidity and suicidal ideation. J Formos Med Assoc 115(11):1019–1020CrossRef

Kazemipour M, Ansari M, Tajrobehkar S, Majdzadeh M, Kermani HR (2008) Removal of lead, cadmium, zinc, and copper from industrial wastewater by carbon developed from walnut, hazelnut, almond, pistachio shell, and apricot stone. J Hazard Mater 150(2):322–327CrossRef

Keane FM, Munn SE, du Vivier AW, Taylor NF, Higgins EM (1999) Analysis of Chinese herbal creams prescribed for dermatological conditions. BMJ (Clin Res Ed) 318(7183):563–564CrossRef

Khatri P, Sirota M, Butte AJ (2012) Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput Biol 8(2):e1002375CrossRef

Khoury EDT, Da Silva Souza G, Da Costa CA, De Araújo AAK, De Oliveira CSB, De Lima Silveira LC, Da Conceição NPM (2015) Somatosensory psychophysical losses in inhabitants of riverside communities of the Tapajós River Basin, Amazon, Brazil: exposure to methylmercury is possibly involved. PLoS ONE 10(12):1–19CrossRef

Kim HS, Kim YJ, Seo YR (2015) An overview of carcinogenic heavy metal: molecular toxicity mechanism and prevention. J Cancer Prev 20(4):232–240CrossRef

Kippler M, Tofail F, Gardner R, Rahman A, Hamadani J, Bottai M, Vahter M (2012) Maternal cadmium exposure during pregnancy and size at birth: a prospective cohort study. Environ Health Perspect 120(2):284–289CrossRef

Ko R (1999) Adverse reactions to watch for in patients using herbal remedies. West J Med (September):181–186

Koneman EW, Roberts GD (2002) Your lab focus. Lab Med 33(12):437–445CrossRef

Konietzka R (2015) Gastrointestinal absorption of uranium compounds—a review. Regul Toxicol Pharmacol 71(1):125–133CrossRef

Kumar A, Usha N, Mishra MK, Tripathi RM, Rout S, Jaspal S (2011) Risk assessment for natural uranium in subsurface water of Punjab State, India. Hum Ecol Risk Assess 17:381–393CrossRef

Lee CP, Lee YH, Lian IB, Su CC (2016) Increased prevalence of esophageal cancer in areas with high levels of nickel in farm soils. J Cancer 7(12):1724–1730CrossRef

Length F (2007) Heavy metal pollution and human biotoxic effects. Int J Phys Sci 2(5):112–118

Liesch T, Hinrichsen S, Goldscheider N (2015) Uranium in groundwater—fertilizers versus geogenic sources. Sci Total Environ 536:981–995CrossRef

Linde K, Vickers A, Hondras M, Ter Riet G, Thormählen J, Berman B, Melchart D (2001) Systematic reviews of complementary therapies—an annotated bibliography. Part 1: acupuncture. BMC Complement Altern Med 1:3

Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ (1996) Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radic Biol Med 21(6):771–781CrossRef

Lobo V, Patil A, Phatak A, Chandra N (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacognosy Rev 4(8):118CrossRef

Mamtani R, Stern P, Dawood I, Cheema S (2011) Metals and disease: a global primary health care perspective. J Toxicol 2011(319136):1–11CrossRef

Mazariegos M, Hambidge KM, Westcott JE, Solomons NW, Raboy V, Das A, Krebs NF (2010) Neither a zinc supplement nor phytate-reduced maize nor their combination enhance growth of 6- to 12-month-old guatemalan infants. J Nutr 1–4(9):1041–1048CrossRef

Morin S, Vivas-Nogues M, Duong TT, Boudou A, Coste M, Delmas F (2007) Dynamics of benthic diatom colonization in a cadmium/zinc-polluted river (Riou-Mort, France). Fundam Appl Limnol/Archiv Für Hydrobiol 168(2):179–187CrossRef

Mumtaz MM, Tully DB, El-Masri HA, De Rosa CT (2002) Gene induction studies and toxicity of chemical mixtures. Environ Health Perspect 110(SUPPL.6):947–956CrossRef

Napolitano V (2001) Complementary medicine use by Mexican migrants in the San Francisco Bay Area. West J Med 174(3):203–206CrossRef

Nishijo M, Nakagawa H, Morikawa Y, Tabata M, Senma M, Miura K, Nogawa K (1995) Mortality of inhabitants in an area polluted by cadmium: 15 year follow up. Occup Environ Med 52(3):181–184CrossRef

O’Brien TJ, Ceryak S, Patierno SR (2003) Complexities of chromium carcinogenesis: role of cellular response, repair and recovery mechanisms. Mutat Res Fundam Mol Mech Mutagenesis 533(1–2):3–36CrossRef

Odewabi AO, Ekor M (2017) Levels of heavy and essential trace metals and their correlation with antioxidant and health status in individuals occupationally exposed to municipal solid wastes. Toxicol Ind Health 33(5):431–442CrossRef

OEHHA (Office of Environmental Health Hazard Assessment Agency California Environmental Protection) (2001) Public health goals for chemicals in drinking water: NICKEL (August)

Paknikar KM, Pethkar AV, Puranik PR (2003) Bioremediation of metalliferous wastes and products using inactivated microbial biomass. Indian J Biotechnol 2(3):426–443

Patil YP, Pawar SH, Jadhav S, Kadu JS (2013) Biochemistry of metal absorption in human body: reference to check impact of nano particles on human being. Int J Sci Res Publ 3(4):1–5

Paul S, Bera D, Chattopadhyay P, Ray L (2006) Biosorption of Pb (II) by Bacillus cereus M1 16 immobilized in calcium alginate gel. J Hazard Subst Res 5(1):2

Prüss-Ustün A, Vickers C, Haefliger P, Bertollini R (2011) Knowns and unknowns on burden of disease due to chemicals: a systematic review. Environ Health 10(1):9CrossRef

Puccetti E, Güller S, Orleth A, Brüggenolte N, Hoelzer D, Ottmann OG, Ruthardt M (2000) BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity. Can Res 60(13):3409–3413

Radespiel-Tröger M, Meyer M (2013) Association between drinking water uranium content and cancer risk in Bavaria, Germany. Int Arch Occup Environ Health 86(7):767–776CrossRef

Rooney JPK (2007) The role of thiols, dithiols, nutritional factors and interacting ligands in the toxicology of mercury. Toxicology 234(3):145–156CrossRef

Samet JM (2011) Radiation and cancer risk: a continuing challenge for epidemiologists. Environ Health 10(1):541–549

Sankhla MS, Kumari M, Nandan M, Kumar R, Agrawal P (2016) Heavy metals contamination in water and their hazardous effect on human health: a review. Int J Curr Microbiol Appl Sci 5:759–766CrossRef

Saper RB, Phillips RS, Sehgal A, Khouri N, Davis RB, Paquin J, Kales SN (2008) Lead, mercury, and arsenic in US- and Indian-manufactured ayurvedic medicines sold via the internet. JAMA J Am Med Assoc 300(8):915–923CrossRef

Schurz F, Sabater-Vilar M, Fink-Gremmels J (2000) Mutagenicity of mercury chloride and mechanisms of cellular defence: the role of metal-binding proteins. Mutagenesis 15:525–530CrossRef

Singh NP, Burleigh DP, Ruth HM, Wrenn ME (1990) Daily U intake in Utah residents from food and drinking water. Health Phys 59(3):333–337

Singh R, Gautam N, Mishra A, Gupta R (2011) Heavy metals and living systems: an overview. Indian J Pharmacol 43(3):246CrossRef

Skipper A, Sims JN, Yedjou CG, Tchounwou PB (2016) Cadmium chloride induces DNA damage and apoptosis of human liver carcinoma cells via oxidative stress. Int J Environ Res Public Health 13(1):1–10CrossRef

Soignet BSL, Frankel SR, Douer D, Tallman MS, Kantarjian H, Calleja E, Warrell RP (2001) United States multicenter study of arsenic trioxide in relapsed acute promyelocytic leukemia. J Clin Oncol Official J Am Soc Clin Oncol 19(18):3852–3860CrossRef

Stevens JJ, Graham B, Walker AM, Tchounwou PB, Rogers C (2010) The effects of arsenic trioxide on DNA synthesis and genotoxicity in human colon cancer cells. Int J Environ Res Public Health 7(5):2018–2032CrossRef

Stohs SJ, Bagchi D (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18(2):321–336CrossRef

Su C, Yang H, Huang S, Lian I (2007) Distinctive features of oral cancer in Changhua county: high incidence, buccal mucosa preponderance, and a close relation to betel quid chewing habit. J Formos Med Assoc 106(3):225–233CrossRef

Takahashi M, Barrett JC, Tsutsui T (2002) Transformation by inorganic arsenic compounds of normal Syrian hamster embryo cells into a neoplastic state in which they become anchorage-independent and cause tumors in newborn hamsters. Int J Cancer 99(5):629–634CrossRef

Tchounwou PB, Patlolla AK, Centeno JA (2003) Invited reviews: carcinogenic and systemic health effects associated with arsenic exposure—a critical review. Toxicol Pathol 31(6):575–588

Tchounwou PB, Centeno JA, Patlolla AK (2004) Arsenic toxicity, mutagenesis, and carcinogenesis—a health risk assessment and management approach. Mol Cell Biochem 255(1–2):47–55CrossRef

Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012a) Molecular, clinical and environmental toxicology, vol 101, Springer, Basel, pp 1–30

Tchounwou PB, Yedjou CG, Patlolla AK, Sutton DJ (2012b) Heavy metal toxicity and the environment. In: Molecular, clinical and environmental toxicology. Springer, Basel, pp 133–164

Velma V, Tchounwou PB (2011) NIH Public Access 698:43–51

Verin AD, Cooke C, Herenyiova M, Patterson CE, Garcia JG (1998) Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses. Am J Physiol 275(4 Pt 1):L788–L799

Village G (2005) Lead exposure in children: prevention, detection, and management. Pediatrics 116(4):1036–1046CrossRef

Volesky B, Holan ZR, About M, Article T (1995) Biosorption of heavy metals. Biotechnol Prog 11(3):235–250CrossRef

Walker AM, Stevens JJ, Ndebele K, Tchounwou PB (2010) Arsenic trioxide modulates DNA synthesis and apoptosis in lung carcinoma cells. Int J Environ Res Public Health 7(5):1996–2007CrossRef

Wen CP, Tsai SP, Cheng TY, Chen CJ, Levy DT, Yang HJ, Eriksen MP (2005) Uncovering the relation between betel quid chewing and cigarette smoking in Taiwan. Tobacco Control 14(SUPPL. 1):16–22CrossRef

Wilke A, Buchholz R, Bunke G (2006) Selective biosorption of heavy metals by algae. Environ Biotechnol 2:47–56

Yamashoji S, Isshiki K (2001) Rapid detection of cytotoxicity of food additives and contaminants by a novel cytotoxicity test, menadione-catalyzed H₂O₂ production assay. Cytotechnology 37(3):171–178CrossRef

Yan G, Viraraghavan T (2000) Effect of pretreatment on the bioadsorption of heavy metals on Mucor rouxii. WATER SA-PRETORIA 26(1):119–124

Yedjou CG, Tchounwou PB (2007) N-acetyl-l-cysteine affords protection against lead-induced cytotoxicity and oxidative stress in human liver carcinoma (HepG2) cells. Int J Environ Res Public Health 4(2):132–137CrossRef

Yedjou CG, Milner JN, Howard CB, Tchounwou PB (2010) Basic apoptotic mechanisms of lead toxicity in human leukemia (Hl-60) cells. Int J Environ Res Public Health 7(5):2008–2017CrossRef

Yedjou CG, Tchounwou HM, Tchounwou PB (2015) DNA damage, cell cycle arrest, and apoptosis induction caused by lead in human leukemia cells. Int J Environ Res Public Health 13(1):56CrossRef

Yuan T, Lian I, Tsai K, Chang T, Chiang C, Su C, Hwang Y (2011) Science of the total environment possible association between nickel and chromium and oral cancer: a case—control study in central Taiwan. Sci Total Environ 409(6):1046–1052CrossRef

Zhang YL, Zhao YC, Wang JX, Zhu HD, Liu QF, Fan YG, Fan TQ (2004) Effect of environmental exposure to cadmium on pregnancy outcome and fetal growth: a study on healthy pregnant women in China. J Environ Sci Health Part A 39(9):2507–2515CrossRef

Zhang R, Ma A, Urbanski SJ, McCafferty DM (2007) Induction of inducible nitric oxide synthase: a protective mechanism in colitis-induced adenocarcinoma. Carcinogenesis 28(5):1122–1130CrossRef

Zofkova I, Davis M, Blahos J (2017) Trace elements have beneficial, as well as detrimental effects on bone homeostasis. Physiol Res 66:391–402

Title: Molecular Mechanisms of Heavy Metal Toxicity in Cancer Progression
Authors: Pragati Singh
Deepak Tiwari
Manish Mishra
Dhruv Kumar
Publisher: Springer International Publishing
Book: Networking of Mutagens in Environmental Toxicology
Print ISBN: 978-3-319-96510-9

Electronic ISBN: 978-3-319-96511-6

Copyright Year: 2019
DOI: https://doi.org/10.1007/978-3-319-96511-6_3

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