Top

Published in:

2020 | OriginalPaper | Chapter

Nanomedicine for Treating Specific Disorders

Authors : M. Ramesh, K. Anand

Published in: Integrative Nanomedicine for New Therapies

Publisher: Springer International Publishing

Activate our intelligent search to find suitable subject content or patents.

search-config

AI-assisted search

Off

Abstract

Nanomedicine utilizes the molecular nanotechnology in the form of nanomaterial, and nanobiosensors to modify the properties of the drug for the treatment of human illness. The nanomedicine improves the pharmacokinetics, pharmacodynamics, stability properties of existing drugs. In addition, the nanomedicine serves as a diagnostic tool to monitor the physiological functions of the human body. The nanomedicine formulates the existing drug without using dose-limiting toxic excipients, and therefore nanomedicines reduce the toxicity of the drug. The sustained and controlled release of drug from nanomedicine also enhances the safety and efficacy. Overall, the therapeutic index of a drug is enhanced when the drug is administered in the form of nanomedicine. At present, a numerous number of nanomedicines have been developed to treat a wide range of human illness like cancer, HIV, kidney diseases, angiogenesis, etc. Recently, nanotechnology has been viewed as a revolutionary discipline in pharmaceutical and medical sciences. The advancements in nanomedicines are continuously growing to treat life-threatening diseases such as cancer, HIV, etc. Despite, there is a significant progress in the development of nanomedicines, the clinical translation of nanomedicine remains challenge in drug development. The present review describes the challenges, recent progress in development, therapeutic properties, clinical role and potential outcome of nanomedicine in treating specific human disorders. It will be useful to simplify the monitoring, diagnosis, and curing of diseases in personalized health care.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Online-Abonnement

Mit Springer Professional "Wirtschaft+Technik" erhalten Sie Zugriff auf:

über 102.000 Bücher
über 537 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Finance + Banking
Management + Führung
Marketing + Vertrieb
Maschinenbau + Werkstoffe
Versicherung + Risiko

Jetzt Wissensvorsprung sichern!

inform now

Springer Professional "Technik"

Online-Abonnement

Mit Springer Professional "Technik" erhalten Sie Zugriff auf:

über 67.000 Bücher
über 390 Zeitschriften

aus folgenden Fachgebieten:

Automobil + Motoren
Bauwesen + Immobilien
Business IT + Informatik
Elektrotechnik + Elektronik
Energie + Nachhaltigkeit
Maschinenbau + Werkstoffe

Jetzt Wissensvorsprung sichern!

inform now

previous chapter Molecular Dynamics Simulations in Drug Discovery and Drug Delivery

next chapter Nanomedicines in Cancer Therapy

Akbarzadeh, A., Rezaei-Sadabady, R., Davaran, S., Joo, S. W., Zarghami, N., Hanifehpour, Y., et al. (2013). Liposome: Classification, preparation, and applications. Nanoscale Research Letters, 8, 102.

Allaker, R. (2010). The use of nanoparticles to control oral biofilm formation. Journal of Dental Research, 89, 1175–1186.

Arruebo, M., Valladares, M., & González-Fernández, Á. (2009). Antibody-conjugated nanoparticles for biomedical applications. Journal of Nanomaterials, 2009, 37.

Asta, M., Kauzlarich, S. M., Liu, K., Navrotsky, A., & Osterloh, F. E. (2007). Inorganic nanoparticles. Unique properties and novel applications. Material Matters (Milwaukee, WI, USA), 2, 3–6.

Azar, D. T. (2006). Corneal angiogenic privilege: Angiogenic and antiangiogenic factors in corneal avascularity, vasculogenesis, and wound healing (an American Ophthalmological Society thesis). Transactions of the American Ophthalmological Society, 104, 264–302.

Bennett, K. M., Zhou, H., Sumner, J. P., Dodd, S. J., Bouraoud, N., Doi, K., et al. (2008). MRI of the basement membrane using charged nanoparticles as contrast agents. Magnetic Resonance in Medicine, 60, 564–574.

Besinis, A., De Peralta, T., & Handy, R. D. (2014). Inhibition of biofilm formation and antibacterial properties of a silver nano-coating on human dentine. Nanotoxicology, 8, 745–754.

Bhaskar, S., & Lim, S. (2017). Engineering protein nanocages as carriers for biomedical applications. NPG Asia Materials, 9, e371.

Birbrair, A., Zhang, T., Wang, Z. M., Messi, M. L., Mintz, A., & Delbono, O. (2015). Pericytes at the intersection between tissue regeneration and pathology. Clinical Science, 128, 81–93.

Birbrair, A., Zhang, T., Wang, Z. M., Messi, M. L., Olson, J. D., Mintz, A., & Delbono, O. (2014). Type-2 pericytes participate in normal and tumoral angiogenesis. American Journal of Physiology-Cell Physiology, 307, C25–C38.

Bose, A., & Wong, T. W. (2015). Nanotechnology-enabled drug delivery for cancer therapy. Nanotechnology applications for tissue engineering (pp. 173–193). Amsterdam: Elsevier.

Boussoufi, F., Gallón, S. M. N., Chang, R., & Webster, T. J. (2018). Synthesis and study of cell-penetrating peptide-modified gold nanoparticles. International Journal of Nanomedicine, 13, 6199–6205.

Buhleier, E., Wehner, W., & Vögtle, F. (1978). ‘Cascade’‐and’ Nonskid‐Chain‐Like’ syntheses of molecular cavity topologies. Chemischer Informationsdienst 9.

Carson, D., Jiang, Y., & Woodrow, K. A. (2016). Tunable release of multiclass anti-HIV drugs that are water-soluble and loaded at high drug content in polyester blended electrospun fibers. Pharmaceutical Research, 33, 125–136.

Chuang, S. Y., Lin, C. H., Huang, T. H., & Fang, J. Y. (2018). Lipid-based nanoparticles as a potential delivery approach in the treatment of rheumatoid arthritis. Nanomaterials, 8, 42.

de Ilarduya, C. T., Sun, Y., & Düzgüneş, N. (2010). Gene delivery by lipoplexes and polyplexes. European Journal of Pharmaceutical Sciences, 40, 159–170.

Duro-Castano, A., Gallon, E., Decker, C., & Vicent, M. J. (2017). Modulating angiogenesis with integrin-targeted nanomedicines. Advanced Drug Delivery Reviews, 119, 101–119.

Etheridge, M. L., Campbell, S. A., Erdman, A. G., Haynes, C. L., Wolf, S. M., & McCullough, J. (2013). The big picture on nanomedicine: The state of investigational and approved nanomedicine products. Nanomedicine: Nanotechnology, Biology and Medicine 9(1), 1–14.

Gannimani, R., Ramesh, M., Mtambo, S., Pillay, K., Soliman, M. E., & Govender, P. (2016). γ-Cyclodextrin capped silver nanoparticles for molecular recognition and enhancement of antibacterial activity of chloramphenicol. Journal of Inorganic Biochemistry, 157, 15–24.

Gao, Y., Zhou, Y., Zhao, L., Zhang, C., Li, Y., Li, J., et al. (2015). Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles. Acta Biomaterialia, 23, 127–135.

Gebel, T., Foth, H., Damm, G., Freyberger, A., Kramer, P. J., Lilienblum, W., et al. (2014). Manufactured nanomaterials: Categorization and approaches to hazard assessment. Archives of Toxicology, 88, 2191–2211.

Hall, C. E. (1953). Introduction to electron microscopy. London: McGra-hill Publishing Company Ltd.

Hare, J. I., Lammers, T., Ashford, M. B., Puri, S., Storm, G., & Barry, S. T. (2017). Challenges and strategies in anti-cancer nanomedicine development: An industry perspective. Advanced Drug Delivery Reviews, 108, 25–38.

Jędrzak, A., Grześkowiak, B. F., Coy, E., Wojnarowicz, J., Szutkowski, K., Jurga, S., et al. (2018). Dendrimer based theranostic nanostructures for combined chemo-and photothermal therapy of liver cancer cells in Vitro. Colloids and Surfaces B: Biointerfaces, 173, 698–708.

Kawamura, A., & Aoyama, Y. (1983). Immunofluorescence in medical science. Tokyo: University of Tokyo Press.

Khurana, A., Tekula, S., & Godugu, C. (2018). Nanoceria suppresses multiple low doses of streptozotocin-induced Type 1 diabetes by inhibition of Nrf2/NF-κB pathway and reduction of apoptosis. Nanomedicine, 13, 1905–1922.

Klibanov, A. L., Maruyama, K., Torchilin, V. P., & Huang, L. (1990). Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Letters, 268, 235–237.

Kreuter, J. (2014). Drug delivery to the central nervous system by polymeric nanoparticles: What do we know? Advanced Drug Delivery Reviews, 71, 2–14.

Lampri, E., & Elli, I. (2013). Angiogenesis: Insights from a systematic overview.

Leuschner, F., Dutta, P., Gorbatov, R., Novobrantseva, T. I., Donahoe, J. S., Courties, G., et al. (2011). Therapeutic siRNA silencing in inflammatory monocytes in mice. Nature Biotechnology, 29, 1005.

Matsumura, Y., & Maeda, H. (1986). A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Research, 46, 6387–6392.

Miller, M. A., Gadde, S., Pfirschke, C., Engblom, C., Sprachman, M. M., Kohler, R. H., Yang, K. S., et al. (2015). Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle. Science Translational Medicine, 7, 314ra183.

Min, Y., Caster, J. M., Eblan, M. J., & Wang, A. Z. (2015). Clinical translation of nanomedicine. Chemical Reviews, 115, 11147–11190.

Pan, D., Caruthers, S. D., Chen, J., Winter, P. M., SenPan, A., Schmieder, A. H., et al. (2010). Nanomedicine strategies for molecular targets with MRI and optical imaging. Future Medicinal Chemistry, 2, 471–490.

Pardridge, W. M. (2005). The blood-brain barrier: Bottleneck in brain drug development. NeuroRx, 2, 3–14.

Pascolini, D., & Mariotti, S. P. (2012). Global estimates of visual impairment: 2010. British Journal of Ophthalmology, 96, 614–618.

Pokorski, J. K., & Steinmetz, N. F. (2010). The art of engineering viral nanoparticles. Molecular Pharmaceutics, 8, 29–43.

Puri, A., Loomis, K., Smith, B., Lee, J. H., Yavlovich, A., Heldman, E., & Blumenthal, R. (2009). Lipid-based nanoparticles as pharmaceutical drug carriers: From concepts to clinic. Critical Reviews™ in Therapeutic Drug Carrier Systems, 26.

Rajeshkumar, S., & Naik, P. (2018). Synthesis and biomedical applications of Cerium oxide nanoparticles–A Review. Biotechnology Reports, 17, 1–5.

Rosan, B., & Lamont, R. J. (2000). Dental plaque formation. Microbes and Infection, 2, 1599–1607.

Sahoo, S. K. (2005). Applications of nanomedicine. Asia Pacific Biotech News, 9, 3.

Santulli, G. (2013). Angiogenesis: Insights from a systematic overview. Nova Biomedical.

Singh, R., & Lillard, J. W., Jr. (2009). Nanoparticle-based targeted drug delivery. Experimental and Molecular Pathology, 86, 215–223.

Sonneville-Aubrun, O., Simonnet, J. T., & L’alloret, F. (2004). Nanoemulsions: A new vehicle for skincare products. Advances in Colloid and Interface Science, 108, 145–149.

Stuart, B. (2005). Infrared spectroscopy. In Kirk‐Othmer encyclopedia of chemical technology.

US National Science Foundation. (2014, February 25). Market report on emerging nanotechnology now available. Market Report. Retrieved June 7, 2016.

Venkatraman, S. (2014). Has nanomedicine lived up to its promise? Nanotechnology, 25, 372501.

Ventola, C. L. (2012). The nanomedicine revolution: Part 1: Emerging concepts. Pharmacy and Therapeutics, 37, 512.

Weng, Y., Liu, J., Jin, S., Guo, W., Liang, X., & Hu, Z. (2017). Nanotechnology-based strategies for treatment of ocular disease. Acta pharmaceutica sinica B, 7, 281–291.

Whitesides, G. M. (2005). Nanoscience, nanotechnology, and chemistry. Small, 1, 172–179.

Yang, S., Yang, Y., Cui, S., Feng, Z., Du, Y., Song, Z., et al. (2018). Chitosan-polyvinyl alcohol nanoscale liquid film-forming system facilitates MRSA-infected wound healing by enhancing antibacterial and antibiofilm properties. International Journal of Nanomedicine, 13, 4987–5002.

Yao, H., Li, J., Song, Y., Zhao, H., Wei, Z., Li, X., et al. (2018). Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells. International Journal of Nanomedicine, 13, 6249–6264.

Yuan, X., Marcano, D. C., Shin, C. S., Hua, X., Isenhart, L. C., Pflugfelder, S. C., & Acharya, G. (2015). Ocular drug delivery nanowafer with enhanced therapeutic efficacy. ACS nano, 9, 1749–1758.

Zhang, B., Jiang, T., Tuo, Y., Jin, K., Luo, Z., Shi, W., et al. (2017). Captopril improves tumor nanomedicine delivery by increasing tumor blood perfusion and enlarging endothelial gaps in tumor blood vessels. Cancer Letters, 410, 12–19.

Zhou, X., Shi, G., Fan, B., Cheng, X., Zhang, X., Wang, X., et al. (2018). Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury. International Journal of Nanomedicine, 13, 6265–6277.

Zuckerman, J. E., & Davis, M. E. (2013). Targeting therapeutics to the glomerulus with nanoparticles. Advances in Chronic Kidney Disease, 20, 500–507.

Title: Nanomedicine for Treating Specific Disorders
Authors: M. Ramesh
K. Anand
Publisher: Springer International Publishing
Book: Integrative Nanomedicine for New Therapies
Print ISBN: 978-3-030-36259-1

Electronic ISBN: 978-3-030-36260-7

Copyright Year: 2020
DOI: https://doi.org/10.1007/978-3-030-36260-7_11

Springer Professional

Abstract

Please log in to get access to your license.

Dont have a licence yet? Then find out more about our products and how to get one now:

Springer Professional "Wirtschaft+Technik"

Springer Professional "Technik"

Premium Partners