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21-08-2023 | REVIEW PAPER

Nanostructures and biomaterials based on silk polymer for medical diagnostic and therapeutic applications

Authors: Elham Afjeh-Dana, Seyed Arash Javadmoosavi, Mostafa Rahvar, Ronak Shabani, Ali Shahbazi, Masoumeh Zahmatkeshan, Behnaz Ashtari

Published in: Polymer Bulletin | Issue 6/2024

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Abstract

Today, SF is a natural polymer with unique features, such as excellent mechanical properties, biocompatibility, biodegradability, and low toxicity, which characterize this material with diverse forms for different purposes. Silk nanoparticles, scaffolds, films, and mats are used in various therapeutic and diagnostic strategies including drug/gene delivery, tissue engineering, biomolecule detection, and wound healing. Therefore, a study that examines all SF applications and evaluates its toxicity helps researchers in future projects. In this study, we comprehensively searched all sources of databases in different years about the medical application of various types of SF. Also, we reviewed the toxicity of SF. Several newer papers were selected for reporting and conclusions. In conclusion, the evaluation of the literature revealed that SF is a promising candidate for a wide range of biomedical applications.

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Title: Nanostructures and biomaterials based on silk polymer for medical diagnostic and therapeutic applications
Authors: Elham Afjeh-Dana
Seyed Arash Javadmoosavi
Mostafa Rahvar
Ronak Shabani
Ali Shahbazi
Masoumeh Zahmatkeshan
Behnaz Ashtari
Publication date: 21-08-2023
Publisher: Springer Berlin Heidelberg
Published in: Polymer Bulletin / Issue 6/2024
Print ISSN: 0170-0839
Electronic ISSN: 1436-2449
DOI: https://doi.org/10.1007/s00289-023-04949-5

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