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01-11-2014 | Research Paper

Nitrogen-doped carbon dots as multifunctional fluorescent probes

Authors: Fengyi Du, Xin Jin, Junhui Chen, Ye Hua, Mulan Cao, Lirong Zhang, Jianan Li, Li Zhang, Jie Jin, Chaoyang Wu, Aihua Gong, Wenrong Xu, Qixiang Shao, Miaomiao Zhang

Published in: Journal of Nanoparticle Research | Issue 11/2014

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Abstract

Highly fluorescent nitrogen-doped carbon dots (NCDs) were prepared through the hydrothermal carbonization of citric acid and ammonium acetate. The resulting NCDs were quasi-spherical particles with an average diameter of approximately 2.1 nm. They exhibited excellent photoluminescent properties and had favorable solubility in water. Furthermore, the NCDs had low cytotoxicity and were readily integrated with cytoplasm. This makes them particularly suitable for multicolor bioimaging. Most importantly, NCDs internalized by cancer cells can be detected at four channels simultaneously with flow cytometry, which further demonstrates that the NCDs can be used as multifunctional fluorescent probes for biomedical applications.

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Title: Nitrogen-doped carbon dots as multifunctional fluorescent probes
Authors: Fengyi Du
Xin Jin
Junhui Chen
Ye Hua
Mulan Cao
Lirong Zhang
Jianan Li
Li Zhang
Jie Jin
Chaoyang Wu
Aihua Gong
Wenrong Xu
Qixiang Shao
Miaomiao Zhang
Publication date: 01-11-2014
Publisher: Springer Netherlands
Published in: Journal of Nanoparticle Research / Issue 11/2014
Print ISSN: 1388-0764
Electronic ISSN: 1572-896X
DOI: https://doi.org/10.1007/s11051-014-2720-8

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