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Journal of Materials Science
Published in: Journal of Materials Science 19/2018

09-07-2018 | Biomaterials

Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy

Authors: Thi Thu Huong Le, Thuc Quang Bui, Thi Minh Thi Ha, Mai Huong Le, Hong Nam Pham, Phuong Thu Ha

Published in: Journal of Materials Science | Issue 19/2018

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Abstract

Chemotherapy in cancer treatment usually leads to serious side effects on patients due to the unselectiveness and high toxicity on normal cells of cancer drugs. Loading cancer drugs into nano-platforms could be an alternative approach to effectively deliver drugs to tumors and reduce toxic exposure on healthy cells. In this work, we synthesized drug delivery nano-systems based on Fe3O4 nanoparticles (obtained from co-precipitation reaction) which could provide targeting of drugs to the tumor sites by an external magnetic field. Also, the magnetic nanoparticles (MNPs) could generate heat to kill cancer cells at a certain temperature range. The systems were designed for loading anticancer agent doxorubicin by using alginate-coated iron oxide MNPs. It was found that the loading was achieved by complex formation of doxorubicin and the alginate layer. Various concentrations of alginate solutions produced different sizes as well as drug loading capacities of the nanoparticles. The highest loading content of 18.96% achieved at the alginate concentration of 4 mg ml−1, corresponding to the mass ratio of alginate to Fe3O4 of around 1:2. The magnetic properties, especially the inductive heating effect of the nanoparticles, along with the impact of the systems on tumor cells were investigated. The results proved that the nanoparticles can serve as a good drug delivery system, in terms of both effective hyperthermia and chemotherapy.
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Metadata
Title
Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy
Authors
Thi Thu Huong Le
Thuc Quang Bui
Thi Minh Thi Ha
Mai Huong Le
Hong Nam Pham
Phuong Thu Ha
Publication date
09-07-2018
Publisher
Springer US
Published in
Journal of Materials Science / Issue 19/2018
Print ISSN: 0022-2461
Electronic ISSN: 1573-4803
DOI
https://doi.org/10.1007/s10853-018-2574-z

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