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Published in: Medical & Biological Engineering & Computing 12/2008

01-12-2008 | Original Article

Passive mechanical properties and constitutive modeling of blood vessels in relation to microstructure

Author: Dimitrios P. Sokolis

Published in: Medical & Biological Engineering & Computing | Issue 12/2008

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Abstract

Mechanical property variations of blood vessels from different anatomical sites supposedly reflect variations in microstructure, but no explicit association has been afforded so far. The objective of the present study was to provide precise histometrical and mechanical data, allowing the identification of such an association for arteries and veins. For biomechanical characterization, a one-dimensional (1D) constitutive model was developed adopting a ‘Fung-type’ exponential function to reproduce the stiffening effect of blood vessels at high stresses and combining it with a power function to reproduce the low-stress response. Histometrical studies were conducted with quantification of fiber composition and waviness for the entire vessel and its layers. Significant correlations were found between the model parameters and extracellular matrix organization. The novel model associates with recently-derived strain-energy functions for the arterial wall, provides powerful fit to uniaxial tension data from all types of vascular tissue studied, and conforms explicitly to microstructure.

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Metadata
Title
Passive mechanical properties and constitutive modeling of blood vessels in relation to microstructure
Author
Dimitrios P. Sokolis
Publication date
01-12-2008
Publisher
Springer-Verlag
Published in
Medical & Biological Engineering & Computing / Issue 12/2008
Print ISSN: 0140-0118
Electronic ISSN: 1741-0444
DOI
https://doi.org/10.1007/s11517-008-0362-7

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